Motif ID: Lef1

Z-value: 1.964


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.699.0e-05Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_98169542 16.441 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr7_-_144939823 11.816 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr14_-_48662740 11.579 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr17_-_70851189 10.312 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_49636847 9.765 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr10_-_92165159 9.065 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr19_+_55742242 7.742 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr5_+_75075464 7.613 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr12_-_119238794 7.460 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr2_+_70474923 6.625 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr3_-_57575760 6.612 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr12_+_103314944 6.288 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr11_+_108920800 6.266 ENSMUST00000140821.1
 Axin2
axin2
chr8_+_108714644 6.224 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr3_+_102010138 6.216 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr8_-_46294592 6.184 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr6_-_148944750 6.132 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr3_-_57575907 5.885 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr19_+_55741884 5.775 ENSMUST00000111658.3
ENSMUST00000111654.1
 Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chr19_+_55742056 5.749 ENSMUST00000111659.2
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 31.0 GO:0048625 myoblast fate commitment(GO:0048625)
1.3 20.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
5.5 16.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
3.8 15.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
3.5 13.9 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
1.8 12.5 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
1.7 11.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.5 9.8 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 9.8 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.3 9.0 GO:0009409 response to cold(GO:0009409)
0.8 8.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
2.6 7.8 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.6 7.6 GO:0048853 forebrain morphogenesis(GO:0048853)
1.1 7.5 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.2 7.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.8 7.3 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.3 7.2 GO:0001967 suckling behavior(GO:0001967)
0.6 7.1 GO:0060539 diaphragm development(GO:0060539)
0.2 7.0 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.3 6.9 GO:0036342 post-anal tail morphogenesis(GO:0036342)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 99.8 GO:0005634 nucleus(GO:0005634)
0.2 70.4 GO:0005667 transcription factor complex(GO:0005667)
3.4 31.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 30.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 13.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
1.8 9.1 GO:0008623 CHRAC(GO:0008623)
0.1 8.9 GO:0005819 spindle(GO:0005819)
0.4 7.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 6.3 GO:0072686 mitotic spindle(GO:0072686)
0.3 6.1 GO:0016580 Sin3 complex(GO:0016580)
2.7 5.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.4 4.2 GO:0042585 germinal vesicle(GO:0042585)
1.0 4.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.8 3.9 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 3.5 GO:0031105 septin complex(GO:0031105)
0.4 3.4 GO:0005833 hemoglobin complex(GO:0005833)
0.2 3.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
1.1 3.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 3.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.5 2.8 GO:0000235 astral microtubule(GO:0000235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 93.4 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
1.8 50.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 20.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
5.5 16.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 13.8 GO:0003677 DNA binding(GO:0003677)
0.5 11.4 GO:0070064 proline-rich region binding(GO:0070064)
0.5 10.6 GO:0070410 co-SMAD binding(GO:0070410)
0.2 10.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 10.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 9.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.9 9.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.4 7.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.4 6.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 6.6 GO:0004697 protein kinase C activity(GO:0004697)
0.0 6.6 GO:0051015 actin filament binding(GO:0051015)
0.1 6.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 5.7 GO:0042169 SH2 domain binding(GO:0042169)
0.1 5.6 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 5.4 GO:0042054 histone methyltransferase activity(GO:0042054)
0.1 5.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)