Motif ID: Lhx2_Hoxc5

Z-value: 0.541

Transcription factors associated with Lhx2_Hoxc5:

Gene SymbolEntrez IDGene Name
Hoxc5 ENSMUSG00000022485.3 Hoxc5
Lhx2 ENSMUSG00000000247.5 Lhx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx2mm10_v2_chr2_+_38339258_38339281-0.553.8e-03Click!


Activity profile for motif Lhx2_Hoxc5.

activity profile for motif Lhx2_Hoxc5


Sorted Z-values histogram for motif Lhx2_Hoxc5

Sorted Z-values for motif Lhx2_Hoxc5



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx2_Hoxc5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_170009892 1.641 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr18_+_37435602 1.027 ENSMUST00000055495.5
 Pcdhb12
protocadherin beta 12
chr4_+_102589687 1.001 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr2_+_65620829 0.907 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr9_+_34904913 0.852 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr15_-_67113909 0.838 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr7_-_14562171 0.790 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr5_-_118244861 0.780 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chrM_+_10167 0.768 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr4_+_105789869 0.765 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr10_-_86732409 0.752 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr7_+_48959089 0.718 ENSMUST00000183659.1
 Nav2
neuron navigator 2
chrM_+_8600 0.696 ENSMUST00000082409.1
 mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr12_-_79007276 0.691 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr6_+_134640940 0.680 ENSMUST00000062755.8
 Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr14_-_64455903 0.665 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chr1_-_24612700 0.640 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr11_-_121388186 0.630 ENSMUST00000106107.2
 Rab40b
Rab40b, member RAS oncogene family
chr18_+_37355271 0.612 ENSMUST00000051163.1
 Pcdhb8
protocadherin beta 8
chr2_-_160619971 0.607 ENSMUST00000109473.1
 Gm14221
predicted gene 14221

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0022904 respiratory electron transport chain(GO:0022904)
0.1 1.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.2 0.9 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.2 0.9 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 0.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 0.7 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.0 0.7 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.6 GO:0030091 protein repair(GO:0030091)
0.0 0.6 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0 0.6 GO:0048821 erythrocyte development(GO:0048821)
0.2 0.5 GO:0019085 early viral transcription(GO:0019085)
0.2 0.5 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.2 0.5 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 0.5 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.5 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0070469 respiratory chain(GO:0070469)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.9 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.7 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.0 0.5 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.4 GO:0090543 Flemming body(GO:0090543)
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.4 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.2 GO:0030552 cAMP binding(GO:0030552)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.8 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.6 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.6 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 0.5 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.5 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.1 0.4 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.4 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)