Motif ID: Lhx3

Z-value: 0.607


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 3.193 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr7_-_45103747 2.693 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr13_+_49608030 2.238 ENSMUST00000021822.5
 Ogn
osteoglycin
chr17_-_67950908 1.292 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr4_+_136143497 1.279 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr13_-_101692624 1.187 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr14_+_80000292 1.010 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr1_-_158356258 0.987 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr3_+_122419772 0.903 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr10_-_33624587 0.827 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr1_-_38821215 0.758 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr2_-_33087169 0.724 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr5_-_70842617 0.715 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr2_+_36230426 0.715 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr4_+_102589687 0.710 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr4_-_14621805 0.662 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr19_+_26623419 0.649 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_33086366 0.636 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr11_+_59306920 0.597 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr3_+_53845086 0.576 ENSMUST00000108014.1
 Gm10985
predicted gene 10985

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0019882 antigen processing and presentation(GO:0019882)
0.3 1.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 1.3 GO:0071398 cellular response to fatty acid(GO:0071398)
0.1 1.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.0 1.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.8 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.6 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.5 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 0.4 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.4 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.3 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.3 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.1 0.3 GO:0035610 protein side chain deglutamylation(GO:0035610)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.0 GO:0042581 specific granule(GO:0042581)
0.0 0.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.1 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.9 2.7 GO:0019770 IgG receptor activity(GO:0019770)
0.0 2.2 GO:0008083 growth factor activity(GO:0008083)
0.3 1.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.7 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.7 GO:0030552 cAMP binding(GO:0030552)
0.0 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 0.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.5 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.4 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.3 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)