Motif ID: Lhx3

Z-value: 0.607


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_103827922 3.193 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr7_-_45103747 2.693 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr13_+_49608030 2.238 ENSMUST00000021822.5
 Ogn
osteoglycin
chr17_-_67950908 1.292 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr4_+_136143497 1.279 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr13_-_101692624 1.187 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr14_+_80000292 1.010 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr1_-_158356258 0.987 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr3_+_122419772 0.903 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr10_-_33624587 0.827 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr1_-_38821215 0.758 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr2_-_33087169 0.724 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr5_-_70842617 0.715 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr2_+_36230426 0.715 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr4_+_102589687 0.710 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr4_-_14621805 0.662 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr19_+_26623419 0.649 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_33086366 0.636 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr11_+_59306920 0.597 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr3_+_53845086 0.576 ENSMUST00000108014.1
 Gm10985
predicted gene 10985
chr3_-_57294880 0.560 ENSMUST00000171384.1
 Tm4sf1
transmembrane 4 superfamily member 1
chr2_-_164171113 0.538 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chr11_+_109543694 0.528 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr4_+_118961578 0.521 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr2_+_125136692 0.518 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr16_+_11406618 0.507 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr1_-_36273425 0.450 ENSMUST00000056946.6
 Neurl3
neuralized homolog 3 homolog (Drosophila)
chr18_+_37477768 0.440 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16
chr2_-_72986716 0.425 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr5_-_62766153 0.417 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_118244861 0.405 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr2_-_84425258 0.394 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr18_+_57468478 0.359 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chrX_-_139871637 0.355 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4

chr6_+_96115249 0.336 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr11_-_30198232 0.329 ENSMUST00000102838.3
 Sptbn1
spectrin beta, non-erythrocytic 1
chr15_+_16778101 0.326 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr2_+_110597298 0.316 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr1_+_177444653 0.315 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr17_-_78684262 0.313 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr6_+_34780412 0.310 ENSMUST00000115016.1
ENSMUST00000115017.1
 Agbl3

ATP/GTP binding protein-like 3

chr8_-_21906412 0.302 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr10_-_62507737 0.299 ENSMUST00000020271.6
 Srgn
serglycin
chr3_+_151437887 0.297 ENSMUST00000046977.7
 Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr5_-_62765618 0.288 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_66985680 0.268 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr14_+_69347587 0.266 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr10_+_75037066 0.242 ENSMUST00000147802.1
ENSMUST00000020391.5
 Rab36

RAB36, member RAS oncogene family

chrX_-_143933089 0.223 ENSMUST00000087313.3
 Dcx
doublecortin
chr3_-_116712644 0.220 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr4_+_147492417 0.217 ENSMUST00000105721.2
 Gm13152
predicted gene 13152
chr15_+_98571004 0.214 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr10_+_116143881 0.207 ENSMUST00000105271.2
 Ptprr
protein tyrosine phosphatase, receptor type, R
chr10_-_53647080 0.201 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr4_-_14621494 0.196 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr10_+_75037291 0.177 ENSMUST00000139384.1
 Rab36
RAB36, member RAS oncogene family
chr9_+_113812547 0.170 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr3_-_67515487 0.167 ENSMUST00000178314.1
ENSMUST00000054825.4
 Rarres1

retinoic acid receptor responder (tazarotene induced) 1

chr19_+_20601958 0.165 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr6_+_124304646 0.160 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chrX_-_94123087 0.157 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr4_+_147132038 0.155 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chrX_-_143933204 0.148 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr4_-_14621669 0.135 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr3_+_84952146 0.131 ENSMUST00000029727.7
 Fbxw7
F-box and WD-40 domain protein 7
chr5_+_66968961 0.109 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr3_+_142620596 0.109 ENSMUST00000165774.1
 Gbp2
guanylate binding protein 2
chr17_-_36032682 0.100 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr10_+_23797052 0.089 ENSMUST00000133289.1
 Slc18b1
solute carrier family 18, subfamily B, member 1
chr3_+_136670076 0.088 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr18_+_60774510 0.083 ENSMUST00000025511.3
 Rps14
ribosomal protein S14
chr17_-_56036546 0.079 ENSMUST00000003268.9
 Sh3gl1
SH3-domain GRB2-like 1
chr5_-_51553896 0.078 ENSMUST00000132734.1
 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr4_+_146610961 0.069 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chr3_+_66985647 0.063 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr7_-_30534180 0.047 ENSMUST00000044338.4
 Arhgap33
Rho GTPase activating protein 33
chr18_+_60774675 0.041 ENSMUST00000118551.1
 Rps14
ribosomal protein S14
chr10_-_64090265 0.034 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr4_-_147809788 0.031 ENSMUST00000105734.3
ENSMUST00000176201.1
 Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr14_-_108914237 0.013 ENSMUST00000100322.2
 Slitrk1
SLIT and NTRK-like family, member 1
chr13_+_93304799 0.008 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chrX_+_66653003 0.005 ENSMUST00000036043.4
 Slitrk2
SLIT and NTRK-like family, member 2
chr1_-_24612700 0.002 ENSMUST00000088336.1
 Gm10222
predicted gene 10222

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.1 1.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.3 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.4 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.3 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.1 0.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.3 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 1.3 GO:0071398 cellular response to fatty acid(GO:0071398)
0.0 0.2 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.1 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 2.7 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.5 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.4 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 1.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.6 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.8 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.2 GO:0060746 parental behavior(GO:0060746)
0.0 0.3 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.3 GO:0032437 cuticular plate(GO:0032437)
0.1 1.0 GO:0042581 specific granule(GO:0042581)
0.1 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 1.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0019770 IgG receptor activity(GO:0019770)
0.8 3.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.3 1.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 0.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.4 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.5 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0 0.7 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.3 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 2.2 GO:0008083 growth factor activity(GO:0008083)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.7 GO:0030552 cAMP binding(GO:0030552)
0.0 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)