Motif ID: Lhx4

Z-value: 0.879


Transcription factors associated with Lhx4:

Gene SymbolEntrez IDGene Name
Lhx4 ENSMUSG00000026468.8 Lhx4



Activity profile for motif Lhx4.

activity profile for motif Lhx4


Sorted Z-values histogram for motif Lhx4

Sorted Z-values for motif Lhx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 6.166 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr7_-_49636847 5.259 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr19_+_44493472 3.952 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr17_-_48432723 3.704 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr16_-_22161450 3.301 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr9_+_119063429 3.049 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr1_-_163289214 3.045 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr17_+_34592248 2.690 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr9_+_72806874 2.669 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr3_+_122419772 2.651 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr4_+_65124174 2.546 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr11_+_59306920 2.482 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr7_-_37773555 2.390 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr12_+_38783503 2.289 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr15_-_103215285 2.204 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr10_+_37139558 2.175 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr4_-_97778042 2.146 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chrX_+_9885622 2.025 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr4_-_3938354 1.968 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr4_-_58499398 1.960 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 6.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 5.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.3 5.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 5.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.4 4.6 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 3.7 GO:0080111 DNA demethylation(GO:0080111)
0.0 3.5 GO:0051028 mRNA transport(GO:0051028)
0.8 3.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 3.0 GO:0048664 neuron fate determination(GO:0048664)
0.1 3.0 GO:0051693 actin filament capping(GO:0051693)
0.0 3.0 GO:0007605 sensory perception of sound(GO:0007605)
0.0 2.5 GO:0051384 response to glucocorticoid(GO:0051384)
0.4 2.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 2.4 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 2.2 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 2.2 GO:0045165 cell fate commitment(GO:0045165)
0.1 2.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.5 2.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 2.0 GO:0060736 prostate gland growth(GO:0060736)
0.0 2.0 GO:0006906 vesicle fusion(GO:0006906)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 4.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.7 GO:0030426 growth cone(GO:0030426)
0.2 2.4 GO:0045180 basal cortex(GO:0045180)
0.1 2.2 GO:0010369 chromocenter(GO:0010369)
0.0 2.2 GO:0000776 kinetochore(GO:0000776)
0.0 1.8 GO:0043198 dendritic shaft(GO:0043198)
0.6 1.7 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.1 1.6 GO:0002102 podosome(GO:0002102)
0.3 1.5 GO:0031523 Myb complex(GO:0031523)
0.1 1.5 GO:0032797 SMN complex(GO:0032797)
0.0 1.5 GO:0005902 microvillus(GO:0005902)
0.0 1.5 GO:0005884 actin filament(GO:0005884)
0.0 1.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)
0.4 1.2 GO:0042585 germinal vesicle(GO:0042585)
0.1 1.1 GO:0071439 clathrin complex(GO:0071439)
0.1 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.8 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 6.4 GO:0005109 frizzled binding(GO:0005109)
0.4 5.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 4.5 GO:0003779 actin binding(GO:0003779)
0.1 4.1 GO:0071837 HMG box domain binding(GO:0071837)
0.1 4.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 3.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.6 3.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 2.7 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 2.6 GO:0004386 helicase activity(GO:0004386)
0.0 2.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.3 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 2.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 2.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 1.8 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.3 1.7 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.2 1.6 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.6 GO:0005504 fatty acid binding(GO:0005504)
0.4 1.5 GO:0019808 polyamine binding(GO:0019808)