Motif ID: Lhx5_Lmx1b_Lhx1

Z-value: 0.469

Transcription factors associated with Lhx5_Lmx1b_Lhx1:

Gene SymbolEntrez IDGene Name
Lhx1 ENSMUSG00000018698.9 Lhx1
Lhx5 ENSMUSG00000029595.7 Lhx5
Lmx1b ENSMUSG00000038765.7 Lmx1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx1mm10_v2_chr11_-_84525514_845255420.067.6e-01Click!
Lhx5mm10_v2_chr5_+_120431770_1204319050.038.9e-01Click!
Lmx1bmm10_v2_chr2_-_33640480_33640511-0.038.9e-01Click!


Activity profile for motif Lhx5_Lmx1b_Lhx1.

activity profile for motif Lhx5_Lmx1b_Lhx1


Sorted Z-values histogram for motif Lhx5_Lmx1b_Lhx1

Sorted Z-values for motif Lhx5_Lmx1b_Lhx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_82539258 1.664 ENSMUST00000097278.3
 Gm6594
predicted pseudogene 6594
chr15_-_93595877 1.172 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr4_+_145510759 0.867 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr11_-_87359011 0.805 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr4_+_145585166 0.797 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr14_+_58893465 0.632 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr4_+_105789869 0.629 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr18_-_66860458 0.603 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr5_+_13398688 0.592 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr17_-_48432723 0.544 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr2_-_165368723 0.496 ENSMUST00000141140.1
ENSMUST00000103085.1
 Zfp663

zinc finger protein 663

chr10_+_37139558 0.470 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr2_+_3770673 0.455 ENSMUST00000177037.1
 Fam107b
family with sequence similarity 107, member B
chr9_-_69451035 0.450 ENSMUST00000071565.5
 Gm4978
predicted gene 4978
chr15_+_99006056 0.407 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr6_+_11926758 0.406 ENSMUST00000133776.1
 Phf14
PHD finger protein 14
chr7_+_39588931 0.385 ENSMUST00000178791.1
ENSMUST00000098511.3
 Gm2058

predicted gene 2058

chr2_-_73580288 0.380 ENSMUST00000028515.3
 Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr1_-_172027269 0.343 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr18_+_55057557 0.311 ENSMUST00000181765.1
 Gm4221
predicted gene 4221

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 0.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.6 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.1 0.6 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.0 0.5 GO:0080111 DNA demethylation(GO:0080111)
0.1 0.4 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 0.4 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.4 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.3 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.3 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.3 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.2 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0042581 specific granule(GO:0042581)
0.0 0.0 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 0.6 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.5 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.4 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.1 0.3 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.3 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.2 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.2 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.1 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)