Motif ID: Lhx8

Z-value: 0.624


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_1543305760.331.0e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_66851513 2.111 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr13_-_66852017 1.456 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr18_+_23415400 1.221 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr8_+_34054622 1.068 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr8_+_104831572 0.967 ENSMUST00000059449.6
 Ces2b
carboxyesterase 2B
chr2_-_67433181 0.885 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr12_+_38783455 0.870 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr12_+_38783503 0.822 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr4_-_136898803 0.766 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr18_+_12972225 0.714 ENSMUST00000025290.5
 Impact
imprinted and ancient
chr13_+_62129894 0.703 ENSMUST00000099449.3
 Zfp808
zinc finger protein 80
chr2_-_72986716 0.656 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr6_-_136173492 0.651 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr13_-_66227573 0.639 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr3_-_73056943 0.629 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr15_+_21111452 0.624 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr13_-_62466709 0.610 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chr2_-_52558539 0.584 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr2_+_65620829 0.534 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr1_-_44218952 0.533 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.9 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.0 0.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 0.7 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.0 0.7 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 0.6 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 0.5 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.5 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.5 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.4 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.2 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.1 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.5 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.0 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.7 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.7 GO:0043022 ribosome binding(GO:0043022)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 0.5 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.1 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)