Motif ID: Lhx8

Z-value: 0.624


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_1543305760.331.0e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_66851513 2.111 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr13_-_66852017 1.456 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr18_+_23415400 1.221 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr8_+_34054622 1.068 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr8_+_104831572 0.967 ENSMUST00000059449.6
 Ces2b
carboxyesterase 2B
chr2_-_67433181 0.885 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr12_+_38783455 0.870 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr12_+_38783503 0.822 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr4_-_136898803 0.766 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr18_+_12972225 0.714 ENSMUST00000025290.5
 Impact
imprinted and ancient
chr13_+_62129894 0.703 ENSMUST00000099449.3
 Zfp808
zinc finger protein 80
chr2_-_72986716 0.656 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr6_-_136173492 0.651 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr13_-_66227573 0.639 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr3_-_73056943 0.629 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr15_+_21111452 0.624 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr13_-_62466709 0.610 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chr2_-_52558539 0.584 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr2_+_65620829 0.534 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr1_-_44218952 0.533 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E
chr17_-_90088343 0.524 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr3_+_107291215 0.518 ENSMUST00000029502.7
 Slc16a4
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr15_-_99820072 0.480 ENSMUST00000109024.2
 Lima1
LIM domain and actin binding 1
chr7_+_91090728 0.478 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_19359740 0.477 ENSMUST00000140836.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chrX_+_101640056 0.467 ENSMUST00000119299.1
ENSMUST00000044475.4
 Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr7_+_88430257 0.462 ENSMUST00000107256.2
 Rab38
RAB38, member of RAS oncogene family
chr7_+_91090697 0.451 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr13_+_65512678 0.440 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr6_+_15185203 0.439 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr4_-_155645408 0.434 ENSMUST00000115821.2
 Gm10563
predicted gene 10563
chr10_-_67912620 0.414 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr15_-_98221056 0.366 ENSMUST00000170618.1
ENSMUST00000141911.1
 Olfr287

olfactory receptor 287

chrX_-_157415286 0.356 ENSMUST00000079945.4
ENSMUST00000138396.1
 Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr14_-_46831984 0.348 ENSMUST00000181311.1
ENSMUST00000074862.2
 Gm10101

predicted gene 10101

chr3_-_116712644 0.345 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr9_-_124493793 0.330 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr18_+_37341702 0.317 ENSMUST00000053037.3
 Pcdhb7
protocadherin beta 7
chr3_+_121953213 0.316 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr8_+_110079758 0.307 ENSMUST00000058804.8
 Zfp612
zinc finger protein 612
chr2_-_175131864 0.306 ENSMUST00000108929.2
 Gm14399
predicted gene 14399
chr16_+_24721842 0.297 ENSMUST00000115314.2
 Lpp
LIM domain containing preferred translocation partner in lipoma
chr10_+_58497918 0.296 ENSMUST00000036576.8
 Ccdc138
coiled-coil domain containing 138
chr11_-_109995775 0.285 ENSMUST00000020948.8
 Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr18_-_43687695 0.285 ENSMUST00000082254.6
 Jakmip2
janus kinase and microtubule interacting protein 2
chr5_-_139129662 0.282 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr14_+_54625305 0.274 ENSMUST00000097177.4
 Psmb11
proteasome (prosome, macropain) subunit, beta type, 11
chr2_+_177508570 0.274 ENSMUST00000108940.2
 Gm14403
predicted gene 14403
chr3_-_100685431 0.266 ENSMUST00000008907.7
 Man1a2
mannosidase, alpha, class 1A, member 2
chr5_-_62765618 0.261 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_126556935 0.252 ENSMUST00000048391.8
 Clspn
claspin
chr17_-_21908092 0.247 ENSMUST00000106026.2
 2210404O09Rik
RIKEN cDNA 2210404O09 gene
chr16_-_16829276 0.245 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr4_-_96591555 0.240 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr13_+_5861489 0.223 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr12_-_20900867 0.221 ENSMUST00000079237.5
 Zfp125
zinc finger protein 125
chr3_-_59210881 0.219 ENSMUST00000040622.1
 P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr5_+_123930675 0.205 ENSMUST00000094320.3
ENSMUST00000165148.1
 Ccdc62

coiled-coil domain containing 62

chr5_+_25759987 0.203 ENSMUST00000128727.1
ENSMUST00000088244.4
 Actr3b

ARP3 actin-related protein 3B

chr2_-_114013619 0.201 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr1_+_17145357 0.196 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chr1_+_33908172 0.192 ENSMUST00000182513.1
ENSMUST00000183034.1
 Dst

dystonin

chr3_+_76075583 0.186 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr3_-_144760841 0.180 ENSMUST00000059091.5
 Clca1
chloride channel calcium activated 1
chr2_-_45110336 0.178 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr11_+_16257706 0.175 ENSMUST00000109645.2
ENSMUST00000109647.2
 Vstm2a

V-set and transmembrane domain containing 2A

chr8_-_69373383 0.162 ENSMUST00000072427.4
 Gm10033
predicted gene 10033
chr5_-_76905463 0.148 ENSMUST00000146570.1
ENSMUST00000142450.1
ENSMUST00000120963.1
 Aasdh


aminoadipate-semialdehyde dehydrogenase


chr14_+_48446340 0.142 ENSMUST00000111735.2
 Tmem260
transmembrane protein 260
chr1_-_74588117 0.138 ENSMUST00000066986.6
 Zfp142
zinc finger protein 142
chr5_+_121795034 0.110 ENSMUST00000162327.1
 Atxn2
ataxin 2
chr9_+_6168601 0.106 ENSMUST00000168039.1
 Pdgfd
platelet-derived growth factor, D polypeptide
chr6_-_71440623 0.106 ENSMUST00000002292.8
 Rmnd5a
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr3_+_106113229 0.103 ENSMUST00000079132.5
ENSMUST00000139086.1
 Chia

chitinase, acidic

chr17_-_31519914 0.085 ENSMUST00000167419.1
ENSMUST00000171291.1
 Wdr4

WD repeat domain 4

chr7_-_28372494 0.066 ENSMUST00000119990.1
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr11_+_44617310 0.058 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr1_-_170867761 0.050 ENSMUST00000027974.6
 Atf6
activating transcription factor 6
chr8_-_41054771 0.048 ENSMUST00000093534.4
 Mtus1
mitochondrial tumor suppressor 1
chr2_+_21205719 0.045 ENSMUST00000054591.3
ENSMUST00000102952.1
ENSMUST00000138965.1
ENSMUST00000138914.1
ENSMUST00000102951.1
 Thnsl1




threonine synthase-like 1 (bacterial)




chr7_-_28372233 0.044 ENSMUST00000094644.4
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr7_-_28372597 0.043 ENSMUST00000144700.1
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr10_-_116549101 0.039 ENSMUST00000164088.1
 Cnot2
CCR4-NOT transcription complex, subunit 2
chr1_+_72284367 0.039 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr8_+_45627709 0.033 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr17_-_24632608 0.027 ENSMUST00000097373.1
 Tsc2
tuberous sclerosis 2
chr5_-_100820929 0.026 ENSMUST00000117364.1
ENSMUST00000055245.6
 Fam175a

family with sequence similarity 175, member A

chr19_-_11336107 0.023 ENSMUST00000056035.2
ENSMUST00000067532.4
 Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr9_+_58129321 0.023 ENSMUST00000034880.3
 Stra6
stimulated by retinoic acid gene 6
chr19_+_11469353 0.022 ENSMUST00000165310.1
 Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C
chr3_-_53017195 0.018 ENSMUST00000036665.4
 Cog6
component of oligomeric golgi complex 6
chr7_-_19359477 0.014 ENSMUST00000047036.8
 Cd3eap
CD3E antigen, epsilon polypeptide associated protein
chr4_+_126556994 0.012 ENSMUST00000147675.1
 Clspn
claspin
chr6_+_11926758 0.009 ENSMUST00000133776.1
 Phf14
PHD finger protein 14
chr7_+_27553244 0.006 ENSMUST00000067386.7
 2310022A10Rik
RIKEN cDNA 2310022A10 gene
chr5_+_67306941 0.005 ENSMUST00000162372.1
ENSMUST00000113676.2
 Slc30a9

solute carrier family 30 (zinc transporter), member 9

chr2_+_73312601 0.003 ENSMUST00000090811.4
ENSMUST00000112050.1
 Scrn3

secernin 3

chr19_-_24961545 0.001 ENSMUST00000025815.8
 Cbwd1
COBW domain containing 1
chr10_-_4432285 0.000 ENSMUST00000155172.1
 Rmnd1
required for meiotic nuclear division 1 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.2 0.5 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.5 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.4 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.9 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 2.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.6 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.7 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.5 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.2 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.1 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.2 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.5 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 0.5 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.1 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.7 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.0 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0 0.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.0 0.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.7 GO:0043022 ribosome binding(GO:0043022)