Motif ID: Mafa

Z-value: 1.404


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_75747922-0.096.6e-01Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_98033181 10.829 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr9_-_98032983 10.034 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr16_-_17576631 7.259 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
 Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr10_+_58813359 6.645 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr7_+_54835959 6.499 ENSMUST00000082373.6
 Luzp2
leucine zipper protein 2
chr14_+_119138415 6.443 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr1_-_136260873 6.433 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr1_-_169747634 6.272 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr16_+_91269759 5.818 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr4_+_102254993 5.764 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr10_-_84440591 4.638 ENSMUST00000020220.8
 Nuak1
NUAK family, SNF1-like kinase, 1
chr16_-_74411292 4.483 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr12_+_3365108 4.415 ENSMUST00000020999.5
 Kif3c
kinesin family member 3C
chr16_+_96467606 4.300 ENSMUST00000061739.8
 Pcp4
Purkinje cell protein 4
chr4_+_102254739 4.113 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr5_+_111417263 4.089 ENSMUST00000094463.4
 Mn1
meningioma 1
chr8_-_70487314 3.981 ENSMUST00000045286.7
 Tmem59l
transmembrane protein 59-like
chr16_-_74411776 3.769 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chrX_-_73869804 3.678 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr1_-_38836090 3.592 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr12_-_86884808 3.386 ENSMUST00000038422.6
 Irf2bpl
interferon regulatory factor 2 binding protein-like
chr17_-_72603709 3.292 ENSMUST00000086639.4
 Alk
anaplastic lymphoma kinase
chr11_-_66525795 2.924 ENSMUST00000123454.1
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr4_+_43406435 2.880 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr15_-_25413752 2.498 ENSMUST00000058845.7
 Basp1
brain abundant, membrane attached signal protein 1
chr5_-_142509653 2.343 ENSMUST00000110784.1
 Radil
Ras association and DIL domains
chr12_+_105453831 2.313 ENSMUST00000178224.1
 D430019H16Rik
RIKEN cDNA D430019H16 gene
chr11_-_66525964 1.984 ENSMUST00000066679.6
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr8_-_105565985 1.791 ENSMUST00000013304.7
 Atp6v0d1
ATPase, H+ transporting, lysosomal V0 subunit D1
chr9_-_51077064 1.765 ENSMUST00000098782.3
 Layn
layilin
chr5_-_124187150 1.739 ENSMUST00000161938.1
 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr4_+_59003121 1.696 ENSMUST00000095070.3
ENSMUST00000174664.1
 Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr6_-_35308110 1.612 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr9_+_108002501 1.555 ENSMUST00000035214.4
ENSMUST00000175874.1
 Ip6k1

inositol hexaphosphate kinase 1

chr1_-_121328024 1.477 ENSMUST00000003818.7
 Insig2
insulin induced gene 2
chr13_+_4233730 1.449 ENSMUST00000081326.6
 Akr1c19
aldo-keto reductase family 1, member C19
chr7_+_140856957 1.415 ENSMUST00000026558.6
 Ric8
resistance to inhibitors of cholinesterase 8 homolog (C. elegans)
chrX_-_20950597 1.413 ENSMUST00000009550.7
 Elk1
ELK1, member of ETS oncogene family
chr8_+_93810832 1.363 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr8_-_84937347 1.357 ENSMUST00000109741.2
ENSMUST00000119820.1
 Mast1

microtubule associated serine/threonine kinase 1

chrX_+_152178945 1.254 ENSMUST00000096275.4
 Iqsec2
IQ motif and Sec7 domain 2
chr9_-_105131775 1.206 ENSMUST00000035179.6
 Nudt16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr7_-_139616309 1.138 ENSMUST00000166503.1
ENSMUST00000093991.3
 E030019B06Rik

RIKEN cDNA E030019B06 gene

chr1_-_121327672 1.114 ENSMUST00000159085.1
ENSMUST00000159125.1
ENSMUST00000161818.1
 Insig2


insulin induced gene 2


chr17_-_46752170 1.049 ENSMUST00000121671.1
ENSMUST00000059844.6
 Cnpy3

canopy 3 homolog (zebrafish)

chr18_-_36197343 0.983 ENSMUST00000115713.1
ENSMUST00000115712.1
 Nrg2

neuregulin 2

chr5_-_24423516 0.950 ENSMUST00000030814.6
 Cdk5
cyclin-dependent kinase 5
chr19_+_27217357 0.920 ENSMUST00000047645.6
ENSMUST00000167487.1
 Vldlr

very low density lipoprotein receptor

chr9_-_109059711 0.896 ENSMUST00000061973.4
 Trex1
three prime repair exonuclease 1
chr11_-_107337556 0.806 ENSMUST00000040380.6
 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr19_+_27217011 0.799 ENSMUST00000164746.1
ENSMUST00000172302.1
 Vldlr

very low density lipoprotein receptor

chr1_-_121327734 0.723 ENSMUST00000160968.1
ENSMUST00000162582.1
 Insig2

insulin induced gene 2

chr11_-_119228461 0.679 ENSMUST00000036113.3
 Tbc1d16
TBC1 domain family, member 16
chr2_+_36230426 0.673 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr17_-_28080595 0.603 ENSMUST00000141806.1
ENSMUST00000043925.8
ENSMUST00000129046.1
 Tcp11


t-complex protein 11


chr1_-_121327776 0.602 ENSMUST00000160688.1
 Insig2
insulin induced gene 2
chr9_-_109059216 0.585 ENSMUST00000112053.1
 Trex1
three prime repair exonuclease 1
chr5_+_24423805 0.569 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr1_+_87183310 0.569 ENSMUST00000044533.8
 Prss56
protease, serine 56
chr1_+_171213969 0.514 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
 Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr17_-_28080567 0.497 ENSMUST00000114836.1
ENSMUST00000042692.5
 Tcp11

t-complex protein 11

chr17_-_47010513 0.497 ENSMUST00000113337.2
ENSMUST00000113335.2
 Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chr10_-_62507737 0.452 ENSMUST00000020271.6
 Srgn
serglycin
chr1_+_146495621 0.416 ENSMUST00000074622.4
 Brinp3
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr7_-_67759735 0.401 ENSMUST00000074233.4
ENSMUST00000051389.8
 Synm

synemin, intermediate filament protein

chr9_-_65580040 0.394 ENSMUST00000068944.7
 Plekho2
pleckstrin homology domain containing, family O member 2
chr17_+_47611570 0.370 ENSMUST00000024778.2
 Med20
mediator complex subunit 20
chr5_-_136987501 0.354 ENSMUST00000137272.1
ENSMUST00000111090.2
 Znhit1

zinc finger, HIT domain containing 1

chr4_-_59138983 0.346 ENSMUST00000107547.1
 AI481877
expressed sequence AI481877
chr17_-_47611449 0.318 ENSMUST00000024783.8
 Bysl
bystin-like
chr2_-_92401237 0.246 ENSMUST00000050312.2
 Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr11_+_87595646 0.218 ENSMUST00000134216.1
 Mtmr4
myotubularin related protein 4
chr13_+_93771656 0.208 ENSMUST00000091403.4
 Arsb
arylsulfatase B
chr4_-_126321669 0.181 ENSMUST00000102617.4
 Adprhl2
ADP-ribosylhydrolase like 2
chrX_+_151047170 0.181 ENSMUST00000026296.7
 Fgd1
FYVE, RhoGEF and PH domain containing 1
chr14_+_64588112 0.164 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr12_-_75177325 0.147 ENSMUST00000042299.2
 Kcnh5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr10_-_81600857 0.144 ENSMUST00000151858.1
ENSMUST00000142948.1
ENSMUST00000072020.2
 Tle6


transducin-like enhancer of split 6, homolog of Drosophila E(spl)


chr18_-_42579652 0.131 ENSMUST00000054738.3
 Gpr151
G protein-coupled receptor 151
chr4_+_21931291 0.130 ENSMUST00000029908.7
 Faxc
failed axon connections homolog (Drosophila)
chrX_-_122397351 0.115 ENSMUST00000079490.4
 Nap1l3
nucleosome assembly protein 1-like 3
chr7_-_101011976 0.087 ENSMUST00000178340.1
ENSMUST00000037540.3
 P2ry2

purinergic receptor P2Y, G-protein coupled 2

chr17_-_27513341 0.045 ENSMUST00000118161.1
 Grm4
glutamate receptor, metabotropic 4
chr10_-_75932468 0.005 ENSMUST00000120281.1
ENSMUST00000000924.6
 Mmp11

matrix metallopeptidase 11


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.1 6.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.8 9.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.6 4.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.5 1.6 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.5 4.6 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.4 4.3 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.4 3.7 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.3 1.7 GO:0034436 glycoprotein transport(GO:0034436)
0.3 3.4 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.3 1.2 GO:0046709 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.3 20.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 4.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 3.9 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 7.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.2 0.9 GO:0033136 serine phosphorylation of STAT3 protein(GO:0033136) serine phosphorylation of STAT protein(GO:0042501)
0.2 2.5 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.2 0.5 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.2 1.6 GO:0006020 inositol metabolic process(GO:0006020)
0.2 0.5 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 4.8 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 1.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.1 5.8 GO:0048663 neuron fate commitment(GO:0048663)
0.1 4.4 GO:0072384 organelle transport along microtubule(GO:0072384)
0.1 1.7 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 1.5 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.4 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 1.4 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 1.4 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.0 3.3 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 2.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0032308 positive regulation of prostaglandin secretion(GO:0032308)
0.0 0.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.0 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 6.2 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.5 4.3 GO:0005883 neurofilament(GO:0005883)
0.4 9.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.4 4.4 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.3 0.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.3 8.3 GO:0030673 axolemma(GO:0030673)
0.2 1.7 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 1.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 4.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.2 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.1 3.7 GO:0044295 axonal growth cone(GO:0044295)
0.1 20.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 0.5 GO:0042629 mast cell granule(GO:0042629)
0.1 2.5 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.4 GO:0043679 axon terminus(GO:0043679)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.7 3.7 GO:0033691 sialic acid binding(GO:0033691)
0.6 1.7 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.5 1.9 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.4 1.6 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.4 1.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 9.9 GO:0030552 cAMP binding(GO:0030552)
0.2 1.4 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.2 6.4 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.2 6.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 1.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 7.8 GO:0015297 antiporter activity(GO:0015297)
0.1 1.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.1 4.7 GO:0019894 kinesin binding(GO:0019894)
0.1 4.6 GO:0002039 p53 binding(GO:0002039)
0.0 3.3 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 1.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.4 GO:0019215 intermediate filament binding(GO:0019215)
0.0 15.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0004673 phosphorelay sensor kinase activity(GO:0000155) protein histidine kinase activity(GO:0004673)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)
0.0 2.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 2.3 GO:0005516 calmodulin binding(GO:0005516)