Motif ID: Mecom

Z-value: 0.454


Transcription factors associated with Mecom:

Gene SymbolEntrez IDGene Name
Mecom ENSMUSG00000027684.10 Mecom



Activity profile for motif Mecom.

activity profile for motif Mecom


Sorted Z-values histogram for motif Mecom

Sorted Z-values for motif Mecom



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecom

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 6.094 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr1_+_152399824 0.760 ENSMUST00000044311.8
 Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr10_+_3740348 0.682 ENSMUST00000120274.1
 Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr8_+_12385769 0.668 ENSMUST00000080795.8
 Gm5607
predicted gene 5607
chr13_+_104287855 0.642 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr7_-_103853199 0.523 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr2_+_71786923 0.502 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr14_+_115042752 0.500 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr3_+_41742615 0.423 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr1_+_156838915 0.406 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr6_+_138140298 0.400 ENSMUST00000008684.4
 Mgst1
microsomal glutathione S-transferase 1
chrX_-_113185485 0.339 ENSMUST00000026607.8
ENSMUST00000113388.2
 Chm

choroidermia

chr13_-_103764502 0.302 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr18_+_4994600 0.294 ENSMUST00000140448.1
 Svil
supervillin
chr13_+_89540636 0.277 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr8_-_18741542 0.274 ENSMUST00000033846.6
 Angpt2
angiopoietin 2
chr2_+_103970115 0.255 ENSMUST00000111143.1
ENSMUST00000138815.1
 Lmo2

LIM domain only 2

chr4_+_11704439 0.247 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr1_-_69685937 0.246 ENSMUST00000027146.2
 Ikzf2
IKAROS family zinc finger 2
chr9_+_72806874 0.232 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr2_+_103969528 0.231 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr2_+_103970221 0.225 ENSMUST00000111140.2
ENSMUST00000111139.2
 Lmo2

LIM domain only 2

chrX_-_145505136 0.221 ENSMUST00000112835.1
 Amot
angiomotin
chr9_+_65890237 0.206 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chrX_-_37110257 0.197 ENSMUST00000076265.6
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr11_-_88718078 0.167 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chrX_-_88760312 0.166 ENSMUST00000182943.1
 Gm27000
predicted gene, 27000
chrX_-_139871637 0.166 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4

chrX_-_145505175 0.163 ENSMUST00000143610.1
 Amot
angiomotin
chr6_+_113392417 0.159 ENSMUST00000032414.4
ENSMUST00000038889.5
 Ttll3

tubulin tyrosine ligase-like family, member 3

chrX_+_9885622 0.144 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr4_+_41569775 0.135 ENSMUST00000102963.3
 Dnaic1
dynein, axonemal, intermediate chain 1
chr5_+_65131184 0.134 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr13_+_49544443 0.125 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr18_-_43477764 0.111 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr14_+_55854115 0.105 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing
chrX_+_169879596 0.093 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr1_+_107511416 0.091 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511489 0.086 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr14_+_55853997 0.085 ENSMUST00000100529.3
 Nynrin
NYN domain and retroviral integrase containing
chr10_-_6980376 0.083 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr6_-_29609811 0.076 ENSMUST00000012679.8
 Tnpo3
transportin 3
chr14_-_52020698 0.076 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr6_-_29609607 0.075 ENSMUST00000115251.1
 Tnpo3
transportin 3
chrX_+_112604274 0.074 ENSMUST00000071814.6
 Zfp711
zinc finger protein 711
chr5_+_134582690 0.073 ENSMUST00000023867.6
 Rfc2
replication factor C (activator 1) 2
chr9_-_13245741 0.073 ENSMUST00000110582.2
 Jrkl
jerky homolog-like (mouse)
chr4_+_128846163 0.062 ENSMUST00000138291.1
 Gm12968
predicted gene 12968
chr8_+_46490968 0.038 ENSMUST00000110372.1
ENSMUST00000130563.1
 Acsl1

acyl-CoA synthetase long-chain family member 1

chr3_+_106034661 0.031 ENSMUST00000170669.2
 Gm4540
predicted gene 4540
chr14_+_87416610 0.030 ENSMUST00000168275.1
ENSMUST00000169504.1
ENSMUST00000170865.1
 Tdrd3


tudor domain containing 3


chr16_-_29541483 0.027 ENSMUST00000057018.8
ENSMUST00000182627.1
 Atp13a4

ATPase type 13A4

chr1_+_45311538 0.021 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr2_+_97467657 0.020 ENSMUST00000059049.7
 Lrrc4c
leucine rich repeat containing 4C
chr4_-_110292719 0.016 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr10_+_5593718 0.002 ENSMUST00000051809.8
 Myct1
myc target 1
chr3_+_36552600 0.002 ENSMUST00000029269.5
ENSMUST00000136890.1
 Exosc9

exosome component 9

chr5_+_66259890 0.001 ENSMUST00000065530.6
 Nsun7
NOL1/NOP2/Sun domain family, member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.5 GO:0035878 nail development(GO:0035878)
0.1 0.5 GO:0015671 oxygen transport(GO:0015671)
0.1 0.4 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.4 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.7 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.2 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.1 GO:0036158 outer dynein arm assembly(GO:0036158)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.5 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.1 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 0.5 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.4 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.5 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.7 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)