Motif ID: Mecp2

Z-value: 2.555


Transcription factors associated with Mecp2:

Gene SymbolEntrez IDGene Name
Mecp2 ENSMUSG00000031393.10 Mecp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecp2mm10_v2_chrX_-_74085656_740856900.116.1e-01Click!


Activity profile for motif Mecp2.

activity profile for motif Mecp2


Sorted Z-values histogram for motif Mecp2

Sorted Z-values for motif Mecp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_87959560 9.817 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_-_72788952 9.024 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr8_-_90348343 7.517 ENSMUST00000109621.3
 Tox3
TOX high mobility group box family member 3
chr9_-_119578981 7.076 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr11_-_89302545 6.726 ENSMUST00000061728.3
 Nog
noggin
chr6_-_72789240 6.685 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_25250720 6.551 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr10_-_42583628 6.502 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr11_+_112782182 6.340 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr2_+_59612034 6.215 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr13_-_56252163 6.168 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr14_-_98169542 6.005 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr11_-_76027726 5.908 ENSMUST00000021207.6
 Fam101b
family with sequence similarity 101, member B
chr1_-_181842334 5.771 ENSMUST00000005003.6
 Lbr
lamin B receptor
chr14_-_118237016 5.647 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21
chr11_+_98412461 5.587 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr16_-_22161450 5.303 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr6_+_120666388 5.297 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr13_-_29984219 5.247 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr13_+_48261427 5.241 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,059 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 29.5 GO:0006397 mRNA processing(GO:0006397)
0.2 26.8 GO:0051028 mRNA transport(GO:0051028)
0.3 15.7 GO:0051225 spindle assembly(GO:0051225)
1.7 15.5 GO:0046499 S-adenosylmethioninamine metabolic process(GO:0046499)
4.8 14.5 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.5 14.0 GO:0006270 DNA replication initiation(GO:0006270)
0.4 13.3 GO:0035329 hippo signaling(GO:0035329)
0.4 13.0 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.4 12.6 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 11.1 GO:0007067 mitotic nuclear division(GO:0007067)
0.5 11.0 GO:0071539 protein localization to centrosome(GO:0071539)
1.8 10.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.6 10.5 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.5 10.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.1 9.9 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
1.4 9.6 GO:0001842 neural fold formation(GO:0001842)
1.4 9.5 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
3.1 9.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.8 9.2 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.9 8.8 GO:0043922 negative regulation by host of viral transcription(GO:0043922)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 347 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 90.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 77.2 GO:0005634 nucleus(GO:0005634)
0.1 71.0 GO:0005654 nucleoplasm(GO:0005654)
0.1 47.5 GO:0005730 nucleolus(GO:0005730)
0.1 37.2 GO:0005694 chromosome(GO:0005694)
0.3 29.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 20.9 GO:0000922 spindle pole(GO:0000922)
0.2 19.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.5 19.1 GO:0043219 lateral loop(GO:0043219)
0.4 17.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 16.3 GO:0043296 apical junction complex(GO:0043296)
0.2 15.1 GO:0005844 polysome(GO:0005844)
0.2 15.0 GO:0005681 spliceosomal complex(GO:0005681)
0.7 13.6 GO:0001741 XY body(GO:0001741)
1.9 13.5 GO:0000796 condensin complex(GO:0000796)
0.2 13.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 11.3 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 10.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.5 10.3 GO:0016580 Sin3 complex(GO:0016580)
0.2 10.2 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 568 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 56.0 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.1 54.9 GO:0003677 DNA binding(GO:0003677)
0.1 45.8 GO:0044822 poly(A) RNA binding(GO:0044822)
0.3 40.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 25.7 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.2 18.4 GO:0042393 histone binding(GO:0042393)
0.8 17.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
2.0 15.6 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.3 15.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 14.3 GO:0004386 helicase activity(GO:0004386)
0.1 13.9 GO:0003714 transcription corepressor activity(GO:0003714)
1.8 12.8 GO:0034056 estrogen response element binding(GO:0034056)
1.2 12.4 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.8 12.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 12.2 GO:0001047 core promoter binding(GO:0001047)
0.6 12.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 12.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.6 11.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 11.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.3 11.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)