Motif ID: Mef2c

Z-value: 0.740


Transcription factors associated with Mef2c:

Gene SymbolEntrez IDGene Name
Mef2c ENSMUSG00000005583.10 Mef2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83573577_835736070.644.9e-04Click!


Activity profile for motif Mef2c.

activity profile for motif Mef2c


Sorted Z-values histogram for motif Mef2c

Sorted Z-values for motif Mef2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 181 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83573577 2.979 ENSMUST00000185052.1
Mef2c
myocyte enhancer factor 2C
chr4_+_144892813 2.350 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr16_+_45093611 2.202 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chrX_-_51681703 1.952 ENSMUST00000088172.5
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr13_+_16011851 1.937 ENSMUST00000042603.6
Inhba
inhibin beta-A
chr18_+_45268876 1.930 ENSMUST00000183850.1
ENSMUST00000066890.7
Kcnn2

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

chr5_+_66745835 1.874 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
Limch1



LIM and calponin homology domains 1



chrX_-_51681856 1.837 ENSMUST00000114871.1
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr4_+_144893077 1.756 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr14_+_101840602 1.657 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr16_+_7069825 1.641 ENSMUST00000056416.7
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr14_+_101840501 1.580 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr8_-_109251698 1.564 ENSMUST00000079189.3
4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr4_+_144893127 1.519 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr7_+_91090697 1.470 ENSMUST00000107196.2
Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 1.458 ENSMUST00000074273.3
Dlg2
discs, large homolog 2 (Drosophila)
chr10_+_69785507 1.450 ENSMUST00000182993.1
Ank3
ankyrin 3, epithelial
chr6_+_108213086 1.446 ENSMUST00000032192.6
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr9_-_112232449 1.338 ENSMUST00000035085.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr3_-_158562199 1.305 ENSMUST00000106044.1
Lrrc7
leucine rich repeat containing 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.6 GO:0042572 retinol metabolic process(GO:0042572)
0.4 4.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 4.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.6 3.8 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.0 3.0 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 2.9 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.2 2.7 GO:0001553 luteinization(GO:0001553)
0.4 1.9 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.0 1.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.8 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 1.7 GO:0007019 microtubule depolymerization(GO:0007019)
0.2 1.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.4 1.2 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.4 1.2 GO:0007525 somatic muscle development(GO:0007525)
0.3 1.2 GO:0035063 nuclear speck organization(GO:0035063)
0.2 1.2 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 1.2 GO:0007614 short-term memory(GO:0007614)
0.0 1.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 1.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 4.1 GO:0016607 nuclear speck(GO:0016607)
0.1 2.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.2 GO:0005614 interstitial matrix(GO:0005614)
0.6 1.9 GO:0043512 inhibin A complex(GO:0043512)
0.0 1.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.5 GO:0044291 cell-cell contact zone(GO:0044291)
0.5 1.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 1.4 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.3 GO:0043194 axon initial segment(GO:0043194)
0.1 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.2 1.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 1.1 GO:0043198 dendritic shaft(GO:0043198)
0.3 0.9 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.5 GO:0044316 cone cell pedicle(GO:0044316)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 4.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 3.8 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.3 3.0 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 2.6 GO:0042805 actinin binding(GO:0042805)
0.4 2.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.2 GO:0001968 fibronectin binding(GO:0001968)
0.5 1.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.5 1.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 1.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 1.2 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 1.2 GO:0019534 toxin transporter activity(GO:0019534)
0.0 1.2 GO:0030674 protein binding, bridging(GO:0030674)
0.2 1.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.2 1.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.3 0.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.9 GO:0019992 diacylglycerol binding(GO:0019992)