Motif ID: Mef2d_Mef2a

Z-value: 1.197

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2dmm10_v2_chr3_+_88142328_881424830.698.6e-05Click!
Mef2amm10_v2_chr7_-_67372846_673728580.452.2e-02Click!


Activity profile for motif Mef2d_Mef2a.

activity profile for motif Mef2d_Mef2a


Sorted Z-values histogram for motif Mef2d_Mef2a

Sorted Z-values for motif Mef2d_Mef2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83573577 9.089 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr11_-_83649349 6.993 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr1_-_134234492 5.672 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr15_+_101266839 5.565 ENSMUST00000023779.6
 Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr19_+_38264761 5.278 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr4_+_144892813 5.137 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr6_-_136171722 5.048 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr9_-_112232449 4.742 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr7_+_91090697 4.720 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 4.622 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr16_+_45093611 4.585 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr16_+_7069825 4.581 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr9_+_34904913 4.044 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr4_+_144893077 3.994 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_121300227 3.939 ENSMUST00000064580.7
 Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr14_+_101729907 3.912 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr2_-_168712853 3.894 ENSMUST00000123156.1
ENSMUST00000156555.1
 Atp9a

ATPase, class II, type 9A

chr5_+_24985840 3.825 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr14_+_101840602 3.810 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr13_-_113663670 3.628 ENSMUST00000054650.4
 Hspb3
heat shock protein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 12.4 GO:0042572 retinol metabolic process(GO:0042572)
0.7 9.3 GO:0045161 neuronal ion channel clustering(GO:0045161)
3.0 9.1 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 7.8 GO:0034605 cellular response to heat(GO:0034605)
0.7 7.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 7.2 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 7.2 GO:0016337 single organismal cell-cell adhesion(GO:0016337)
0.8 7.0 GO:0043615 astrocyte cell migration(GO:0043615)
1.2 6.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
1.0 6.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.9 5.7 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.0 5.3 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
1.7 5.2 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.3 5.0 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 4.6 GO:0006342 chromatin silencing(GO:0006342)
0.9 4.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.7 4.3 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.2 4.1 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.8 4.0 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.6 4.0 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.5 9.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 7.1 GO:0014704 intercalated disc(GO:0014704)
0.9 6.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 6.2 GO:0016607 nuclear speck(GO:0016607)
0.0 5.9 GO:0031225 anchored component of membrane(GO:0031225)
0.3 5.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.3 5.7 GO:0032279 asymmetric synapse(GO:0032279)
0.0 5.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 5.0 GO:0043083 synaptic cleft(GO:0043083)
0.3 4.6 GO:0005614 interstitial matrix(GO:0005614)
1.4 4.3 GO:0043512 inhibin A complex(GO:0043512)
0.5 3.9 GO:0001520 outer dense fiber(GO:0001520)
0.0 3.8 GO:0043198 dendritic shaft(GO:0043198)
0.1 3.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 3.7 GO:0016605 PML body(GO:0016605)
0.1 3.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 3.5 GO:0031965 nuclear membrane(GO:0031965)
0.1 3.2 GO:0045171 intercellular bridge(GO:0045171)
0.1 3.1 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 9.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 7.3 GO:0042805 actinin binding(GO:0042805)
1.2 7.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 7.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.6 6.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.1 6.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.9 6.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.2 6.1 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 6.1 GO:0051018 protein kinase A binding(GO:0051018)
0.5 6.0 GO:0003680 AT DNA binding(GO:0003680)
0.8 5.7 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.3 5.2 GO:0030275 LRR domain binding(GO:0030275)
0.2 4.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 4.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 4.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 4.6 GO:0003729 mRNA binding(GO:0003729)
0.0 4.3 GO:0008017 microtubule binding(GO:0008017)
0.3 4.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
1.3 3.9 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)