Motif ID: Mnx1_Lhx6_Lmx1a

Z-value: 0.760

Transcription factors associated with Mnx1_Lhx6_Lmx1a:

Gene SymbolEntrez IDGene Name
Lhx6 ENSMUSG00000026890.13 Lhx6
Lmx1a ENSMUSG00000026686.8 Lmx1a
Mnx1 ENSMUSG00000001566.8 Mnx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx6mm10_v2_chr2_-_36104060_36104073-0.643.8e-04Click!
Lmx1amm10_v2_chr1_+_167689552_1676895630.291.5e-01Click!


Activity profile for motif Mnx1_Lhx6_Lmx1a.

activity profile for motif Mnx1_Lhx6_Lmx1a


Sorted Z-values histogram for motif Mnx1_Lhx6_Lmx1a

Sorted Z-values for motif Mnx1_Lhx6_Lmx1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_20737306 5.404 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr8_-_61902669 4.724 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr9_+_119063429 3.253 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr5_+_139543889 2.773 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_-_147264124 2.677 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr14_-_118052235 2.333 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr13_-_102905740 2.161 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_125404072 2.121 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_-_88410295 1.993 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr19_+_44493472 1.982 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr15_+_25773985 1.980 ENSMUST00000125667.1
 Myo10
myosin X
chr2_+_25372315 1.947 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr3_+_125404292 1.946 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr13_-_102906046 1.711 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr2_-_168767136 1.690 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr14_-_48665098 1.672 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr13_-_53473074 1.670 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr4_-_97778042 1.629 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr9_+_65890237 1.557 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr17_+_17402672 1.523 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0008360 regulation of cell shape(GO:0008360)
0.3 4.7 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.4 3.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 3.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 3.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 2.8 GO:0051693 actin filament capping(GO:0051693)
0.4 2.7 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.6 2.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.8 2.3 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.6 2.3 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.4 2.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 1.8 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.6 1.7 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.0 1.7 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.1 1.6 GO:0019985 translesion synthesis(GO:0019985)
0.5 1.5 GO:0015889 cobalamin transport(GO:0015889)
0.1 1.5 GO:0097352 autophagosome maturation(GO:0097352)
0.5 1.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 1.3 GO:0060539 diaphragm development(GO:0060539)
0.1 1.3 GO:0031017 exocrine pancreas development(GO:0031017)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 GO:0002102 podosome(GO:0002102)
0.0 2.9 GO:0000792 heterochromatin(GO:0000792)
0.6 2.3 GO:0060187 cell pole(GO:0060187)
0.1 2.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.3 2.0 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 2.0 GO:0016459 myosin complex(GO:0016459)
0.0 1.9 GO:0043296 apical junction complex(GO:0043296)
0.4 1.8 GO:0031523 Myb complex(GO:0031523)
0.0 1.8 GO:0070469 respiratory chain(GO:0070469)
0.3 1.7 GO:0008623 CHRAC(GO:0008623)
0.0 1.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.4 GO:0000776 kinetochore(GO:0000776)
0.0 1.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 1.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 0.9 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.9 GO:0098536 deuterosome(GO:0098536)
0.1 0.9 GO:0005915 zonula adherens(GO:0005915)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.0 GO:0003779 actin binding(GO:0003779)
0.0 8.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.6 4.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 3.1 GO:0000287 magnesium ion binding(GO:0000287)
0.3 2.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 2.7 GO:0005109 frizzled binding(GO:0005109)
0.2 2.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 2.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.1 GO:0008483 transaminase activity(GO:0008483)
0.5 1.8 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 1.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.6 GO:0070410 co-SMAD binding(GO:0070410)
0.2 1.5 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 1.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 1.3 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.4 1.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 1.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)