Motif ID: Msx1_Lhx9_Barx1_Rax_Dlx6
Z-value: 0.687
Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Barx1 | ENSMUSG00000021381.4 | Barx1 |
Dlx6 | ENSMUSG00000029754.7 | Dlx6 |
Lhx9 | ENSMUSG00000019230.8 | Lhx9 |
Msx1 | ENSMUSG00000048450.10 | Msx1 |
Rax | ENSMUSG00000024518.3 | Rax |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Lhx9 | mm10_v2_chr1_-_138848576_138848603 | -0.75 | 8.4e-06 | Click! |
Rax | mm10_v2_chr18_-_65939048_65939089 | -0.67 | 2.0e-04 | Click! |
Dlx6 | mm10_v2_chr6_+_6863269_6863334 | -0.49 | 1.2e-02 | Click! |
Msx1 | mm10_v2_chr5_-_37824580_37824584 | -0.45 | 2.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.1 | 9.3 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
0.9 | 6.6 | GO:0019532 | oxalate transport(GO:0019532) |
0.8 | 4.7 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
0.7 | 2.2 | GO:0050975 | sensory perception of touch(GO:0050975) |
0.6 | 1.8 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
0.6 | 1.7 | GO:0021852 | pyramidal neuron migration(GO:0021852) |
0.4 | 6.5 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
0.4 | 3.5 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
0.4 | 0.4 | GO:0060915 | fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915) |
0.4 | 2.7 | GO:0021847 | ventricular zone neuroblast division(GO:0021847) |
0.4 | 2.3 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.4 | 9.4 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
0.4 | 1.9 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
0.3 | 0.9 | GO:0060060 | post-embryonic retina morphogenesis in camera-type eye(GO:0060060) |
0.3 | 1.1 | GO:0016198 | axon choice point recognition(GO:0016198) |
0.3 | 1.1 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.3 | 0.8 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
0.2 | 0.5 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.2 | 0.9 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
0.1 | 0.6 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
0.1 | 1.6 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
0.1 | 0.7 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
0.1 | 0.8 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
0.1 | 1.9 | GO:0001553 | luteinization(GO:0001553) |
0.1 | 0.6 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
0.1 | 2.1 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
0.1 | 0.5 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
0.1 | 0.4 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
0.1 | 0.4 | GO:0061055 | myotome development(GO:0061055) |
0.1 | 3.7 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
0.1 | 0.4 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
0.1 | 0.7 | GO:0097460 | positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) |
0.1 | 1.0 | GO:0021860 | pyramidal neuron development(GO:0021860) |
0.1 | 0.2 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) regulation of vascular wound healing(GO:0061043) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) |
0.1 | 0.2 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
0.1 | 0.4 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818) |
0.1 | 1.2 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
0.1 | 0.2 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
0.1 | 0.2 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
0.0 | 0.1 | GO:0021893 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) |
0.0 | 1.7 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.0 | 0.2 | GO:0035063 | nuclear speck organization(GO:0035063) |
0.0 | 0.3 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.0 | 4.5 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
0.0 | 0.1 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
0.0 | 1.6 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
0.0 | 0.3 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.0 | 2.9 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.0 | 0.1 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
0.0 | 0.6 | GO:0060074 | synapse maturation(GO:0060074) |
0.0 | 1.0 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
0.0 | 0.5 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
0.0 | 0.9 | GO:0006376 | mRNA splice site selection(GO:0006376) |
0.0 | 0.4 | GO:0044253 | positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253) |
0.0 | 0.2 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
0.0 | 0.6 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
0.0 | 0.4 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
0.0 | 0.1 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
0.0 | 0.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
0.0 | 0.1 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
0.0 | 0.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.0 | 0.1 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
0.0 | 1.4 | GO:0098792 | xenophagy(GO:0098792) |
0.0 | 0.3 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
0.0 | 1.8 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
0.0 | 0.0 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 4.1 | GO:0071953 | elastic fiber(GO:0071953) |
0.6 | 6.5 | GO:0043083 | synaptic cleft(GO:0043083) |
0.2 | 0.7 | GO:0043512 | inhibin A complex(GO:0043512) |
0.2 | 5.0 | GO:0071565 | nBAF complex(GO:0071565) |
0.2 | 2.9 | GO:0005614 | interstitial matrix(GO:0005614) |
0.1 | 2.4 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.1 | 0.4 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
0.1 | 2.2 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
0.1 | 1.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.1 | 1.1 | GO:0043205 | fibril(GO:0043205) |
0.1 | 0.7 | GO:0097433 | dense body(GO:0097433) |
0.1 | 0.5 | GO:0090543 | Flemming body(GO:0090543) |
0.1 | 1.1 | GO:0031527 | filopodium membrane(GO:0031527) |
0.1 | 1.8 | GO:0030673 | axolemma(GO:0030673) |
0.1 | 1.4 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.0 | 2.5 | GO:0044295 | axonal growth cone(GO:0044295) |
0.0 | 0.6 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
0.0 | 0.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
0.0 | 0.5 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 1.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 0.2 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.0 | 5.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 0.3 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
0.0 | 0.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.0 | 0.1 | GO:0070688 | MLL5-L complex(GO:0070688) |
0.0 | 0.6 | GO:0016328 | lateral plasma membrane(GO:0016328) |
0.0 | 8.8 | GO:0043025 | neuronal cell body(GO:0043025) |
0.0 | 0.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 0.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.0 | 0.6 | GO:0045202 | synapse(GO:0045202) |
0.0 | 0.0 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 6.5 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
0.6 | 6.6 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.6 | 4.7 | GO:0001618 | virus receptor activity(GO:0001618) |
0.2 | 1.1 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.2 | 1.8 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.2 | 2.7 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
0.2 | 1.0 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
0.2 | 1.9 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.2 | 9.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.1 | 0.8 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
0.1 | 0.7 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.1 | 2.9 | GO:0001968 | fibronectin binding(GO:0001968) |
0.1 | 3.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.1 | 0.4 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
0.1 | 0.7 | GO:0015091 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
0.1 | 0.4 | GO:0050436 | microfibril binding(GO:0050436) |
0.1 | 0.4 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
0.1 | 0.3 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.1 | 2.2 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.1 | 2.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.1 | 3.5 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.1 | 3.0 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.1 | 0.4 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.1 | 0.5 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.1 | 0.5 | GO:0038191 | neuropilin binding(GO:0038191) |
0.0 | 3.7 | GO:0005262 | calcium channel activity(GO:0005262) |
0.0 | 0.6 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
0.0 | 0.6 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
0.0 | 0.6 | GO:0016208 | AMP binding(GO:0016208) |
0.0 | 0.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
0.0 | 0.1 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
0.0 | 1.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.0 | 0.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.0 | 0.1 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.0 | 0.1 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
0.0 | 0.7 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.0 | 0.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.0 | 0.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 0.5 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.0 | 0.3 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 0.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
0.0 | 0.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |