Motif ID: Msx2_Hoxd4

Z-value: 0.817

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.413.9e-02Click!


Activity profile for motif Msx2_Hoxd4.

activity profile for motif Msx2_Hoxd4


Sorted Z-values histogram for motif Msx2_Hoxd4

Sorted Z-values for motif Msx2_Hoxd4



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Showing 1 to 20 of 132 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 5.806 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_21111452 4.107 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr1_+_159737510 3.559 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_-_62765618 2.667 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_-_88471396 2.557 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr2_-_63184253 2.521 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr6_-_36811361 2.484 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr3_+_62419668 2.048 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr2_+_4017727 1.957 ENSMUST00000177457.1
 Frmd4a
FERM domain containing 4A
chr2_-_63184170 1.910 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr12_+_74297474 1.815 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr6_-_136171722 1.814 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr12_+_38783503 1.502 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr11_+_103133303 1.418 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr3_-_85741389 1.367 ENSMUST00000094148.4
 Fam160a1
family with sequence similarity 160, member A1
chr17_-_90088343 1.365 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr11_+_103133333 1.297 ENSMUST00000124928.1
ENSMUST00000062530.4
 Hexim2

hexamethylene bis-acetamide inducible 2

chr15_-_37459327 1.254 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr13_+_51408618 1.250 ENSMUST00000087978.3
 S1pr3
sphingosine-1-phosphate receptor 3
chr4_-_129121889 1.179 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 4.4 GO:0051291 protein heterooligomerization(GO:0051291)
1.2 3.6 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.8 2.5 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 2.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 2.4 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 2.0 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 2.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 1.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 1.8 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.3 1.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 1.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.4 1.2 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 1.2 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 1.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 1.1 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.1 1.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.9 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 0.9 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.6 GO:0072534 perineuronal net(GO:0072534)
0.0 2.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.9 GO:0005923 bicellular tight junction(GO:0005923)
0.2 1.8 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.2 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.0 GO:0071439 clathrin complex(GO:0071439)
0.2 0.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 0.8 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.4 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.4 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 0.3 GO:0070765 gamma-secretase complex(GO:0070765)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 6.9 GO:0005509 calcium ion binding(GO:0005509)
0.2 4.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.2 3.6 GO:0046625 sphingolipid binding(GO:0046625)
0.4 2.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.8 2.5 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 1.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 1.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 1.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 1.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.1 GO:0030552 cAMP binding(GO:0030552)
0.2 1.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 1.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.9 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 0.8 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)