Motif ID: Msx3

Z-value: 0.364


Transcription factors associated with Msx3:

Gene SymbolEntrez IDGene Name
Msx3 ENSMUSG00000025469.9 Msx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx3mm10_v2_chr7_-_140049140_1400491800.048.5e-01Click!


Activity profile for motif Msx3.

activity profile for motif Msx3


Sorted Z-values histogram for motif Msx3

Sorted Z-values for motif Msx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_53975246 1.115 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr4_-_14621805 0.969 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr2_-_45117349 0.856 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr4_-_14621494 0.715 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr1_-_158356258 0.664 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_+_81257277 0.570 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr13_+_83732438 0.518 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chrX_-_143933204 0.467 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr10_+_39612934 0.448 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr4_+_102254739 0.447 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chrX_-_143933089 0.424 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_-_33087169 0.400 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_-_33086366 0.400 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr7_+_103550368 0.392 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr5_+_14514918 0.385 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr18_+_37819543 0.376 ENSMUST00000055935.5
 Pcdhga9
protocadherin gamma subfamily A, 9
chr17_+_21383725 0.320 ENSMUST00000056107.4
ENSMUST00000162659.1
 Zfp677

zinc finger protein 677

chr4_-_14621669 0.319 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr9_+_35423582 0.284 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr7_-_127895578 0.280 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr6_+_134640940 0.263 ENSMUST00000062755.8
 Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr10_+_88379217 0.258 ENSMUST00000130301.1
ENSMUST00000020251.8
 Gnptab

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

chrX_+_16619698 0.250 ENSMUST00000026013.5
 Maoa
monoamine oxidase A
chr11_+_70018421 0.247 ENSMUST00000108588.1
 Dlg4
discs, large homolog 4 (Drosophila)
chr15_+_82252397 0.239 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr9_-_15301555 0.209 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr12_+_72441852 0.209 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr7_+_3645267 0.202 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr18_+_57468478 0.200 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr16_+_11406618 0.158 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr8_+_72219726 0.150 ENSMUST00000003123.8
 Fam32a
family with sequence similarity 32, member A
chr12_+_102128718 0.150 ENSMUST00000159329.1
 Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr5_+_88583527 0.149 ENSMUST00000031229.6
 Rufy3
RUN and FYVE domain containing 3
chr12_+_72441933 0.149 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr8_+_107031218 0.138 ENSMUST00000034388.9
 Vps4a
vacuolar protein sorting 4a (yeast)
chr5_-_62766153 0.137 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_-_24527830 0.124 ENSMUST00000176353.1
ENSMUST00000176237.1
 Traf7

TNF receptor-associated factor 7

chr10_+_88379127 0.124 ENSMUST00000127615.1
 Gnptab
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chrM_+_9870 0.122 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr11_+_53433299 0.107 ENSMUST00000018382.6
 Gdf9
growth differentiation factor 9
chr3_+_94837533 0.105 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr1_-_52190901 0.105 ENSMUST00000156887.1
ENSMUST00000129107.1
 Gls

glutaminase

chr7_-_99141068 0.105 ENSMUST00000037968.8
 Uvrag
UV radiation resistance associated gene
chr17_-_24527925 0.096 ENSMUST00000176652.1
 Traf7
TNF receptor-associated factor 7
chr3_+_138374121 0.089 ENSMUST00000171054.1
 Adh6-ps1
alcohol dehydrogenase 6 (class V), pseudogene 1
chrX_+_101449078 0.089 ENSMUST00000033674.5
 Itgb1bp2
integrin beta 1 binding protein 2
chr12_-_84617326 0.081 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr3_+_94837702 0.080 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
 Pogz


pogo transposable element with ZNF domain


chr6_+_145934113 0.073 ENSMUST00000032383.7
 Sspn
sarcospan
chr10_-_76110956 0.071 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr15_+_44787746 0.067 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr11_+_116843278 0.058 ENSMUST00000106370.3
 Mettl23
methyltransferase like 23
chr16_+_49699198 0.053 ENSMUST00000046777.4
ENSMUST00000142682.1
 Ift57

intraflagellar transport 57

chr12_+_71136848 0.052 ENSMUST00000149564.1
ENSMUST00000045907.8
 2700049A03Rik

RIKEN cDNA 2700049A03 gene

chr6_+_8948608 0.042 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr4_-_129378116 0.041 ENSMUST00000030610.2
 Zbtb8a
zinc finger and BTB domain containing 8a
chr2_+_121956411 0.034 ENSMUST00000110578.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr2_+_121956651 0.027 ENSMUST00000110574.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr15_+_38661904 0.023 ENSMUST00000022904.6
 Atp6v1c1
ATPase, H+ transporting, lysosomal V1 subunit C1
chr4_+_134930898 0.021 ENSMUST00000030622.2
 Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr9_+_44398176 0.013 ENSMUST00000165839.1
 Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr12_-_71136611 0.007 ENSMUST00000021486.8
ENSMUST00000166120.1
 Timm9

translocase of inner mitochondrial membrane 9

chr2_-_150255591 0.001 ENSMUST00000063463.5
 Gm21994
predicted gene 21994

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0019532 oxalate transport(GO:0019532)
0.1 0.9 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.4 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 0.3 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.4 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0042701 progesterone secretion(GO:0042701)
0.0 0.4 GO:0048305 immunoglobulin secretion(GO:0048305)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.2 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.5 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.1 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.4 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.2 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.2 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0048038 quinone binding(GO:0048038)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0043015 cAMP binding(GO:0030552) gamma-tubulin binding(GO:0043015)