Motif ID: Mzf1

Z-value: 0.992


Transcription factors associated with Mzf1:

Gene SymbolEntrez IDGene Name
Mzf1 ENSMUSG00000030380.10 Mzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mzf1mm10_v2_chr7_-_13054665_130547640.125.5e-01Click!


Activity profile for motif Mzf1.

activity profile for motif Mzf1


Sorted Z-values histogram for motif Mzf1

Sorted Z-values for motif Mzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_55741810 3.400 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr2_-_148045891 3.177 ENSMUST00000109964.1
 Foxa2
forkhead box A2
chr8_-_91801948 3.049 ENSMUST00000175795.1
 Irx3
Iroquois related homeobox 3 (Drosophila)
chr15_-_99087817 2.869 ENSMUST00000064462.3
 C1ql4
complement component 1, q subcomponent-like 4
chr5_+_139543889 2.405 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr7_+_131542867 2.153 ENSMUST00000046093.5
 Hmx3
H6 homeobox 3
chr10_+_19356558 2.023 ENSMUST00000053225.5
 Olig3
oligodendrocyte transcription factor 3
chr11_+_84525669 2.003 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene

chr8_-_91801547 1.970 ENSMUST00000093312.4
 Irx3
Iroquois related homeobox 3 (Drosophila)
chr19_+_55898553 1.916 ENSMUST00000148666.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr9_-_99876147 1.915 ENSMUST00000054819.8
 Sox14
SRY-box containing gene 14
chr11_-_95514570 1.736 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr2_-_33640480 1.732 ENSMUST00000176067.1
ENSMUST00000041730.4
 Lmx1b

LIM homeobox transcription factor 1 beta

chr3_+_103575275 1.676 ENSMUST00000090697.4
 Syt6
synaptotagmin VI
chr2_+_90885860 1.672 ENSMUST00000111466.2
 C1qtnf4
C1q and tumor necrosis factor related protein 4
chr10_-_109010955 1.583 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr2_-_147186389 1.553 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr2_-_9878580 1.486 ENSMUST00000102976.3
 Gata3
GATA binding protein 3
chr1_-_89933290 1.482 ENSMUST00000036954.7
 Gbx2
gastrulation brain homeobox 2
chr1_+_19103022 1.472 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 244 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.5 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 5.1 GO:2000821 regulation of grooming behavior(GO:2000821)
1.5 4.5 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
1.4 4.2 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 3.0 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.2 2.9 GO:0071625 vocalization behavior(GO:0071625)
0.1 2.9 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.9 2.7 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.3 2.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.5 2.3 GO:0097475 motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.2 1.8 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 1.7 GO:0042048 olfactory behavior(GO:0042048)
0.5 1.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.3 1.6 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.2 1.6 GO:0005513 detection of calcium ion(GO:0005513)
0.2 1.6 GO:0048149 behavioral response to ethanol(GO:0048149)
0.5 1.5 GO:0035799 ureter maturation(GO:0035799) cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.4 1.5 GO:0002074 extraocular skeletal muscle development(GO:0002074) pulmonary myocardium development(GO:0003350) subthalamus development(GO:0021539) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.2 1.5 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 1.5 GO:2001222 regulation of neuron migration(GO:2001222)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 7.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 5.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 4.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 4.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 3.9 GO:0005581 collagen trimer(GO:0005581)
0.0 3.4 GO:0043198 dendritic shaft(GO:0043198)
0.1 2.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.4 GO:0071565 nBAF complex(GO:0071565)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.3 1.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 1.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 1.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 1.5 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 1.4 GO:0031143 pseudopodium(GO:0031143)
0.0 1.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 1.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 1.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.9 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 6.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 6.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.5 4.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 3.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 2.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.6 1.9 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 1.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.8 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 1.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 1.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.3 1.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 1.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.4 1.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 1.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.3 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 1.3 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)