Motif ID: Nanog

Z-value: 0.939


Transcription factors associated with Nanog:

Gene SymbolEntrez IDGene Name
Nanog ENSMUSG00000012396.6 Nanog

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nanogmm10_v2_chr6_+_122707489_1227076080.413.6e-02Click!


Activity profile for motif Nanog.

activity profile for motif Nanog


Sorted Z-values histogram for motif Nanog

Sorted Z-values for motif Nanog



Network of associatons between targets according to the STRING database.



First level regulatory network of Nanog

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_116067213 2.363 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr4_+_154960915 2.229 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr10_+_58394381 2.224 ENSMUST00000105468.1
 Lims1
LIM and senescent cell antigen-like domains 1
chr1_-_52490736 2.206 ENSMUST00000170269.1
 Nab1
Ngfi-A binding protein 1
chr10_+_58394361 2.033 ENSMUST00000020077.4
 Lims1
LIM and senescent cell antigen-like domains 1
chr2_+_20737306 1.950 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chrY_-_1245685 1.835 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr13_-_85127514 1.803 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr7_-_115846080 1.764 ENSMUST00000166207.1
 Sox6
SRY-box containing gene 6
chr9_+_65890237 1.664 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr12_+_72441933 1.653 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr2_+_134786154 1.633 ENSMUST00000110116.1
 Plcb1
phospholipase C, beta 1
chr10_-_42583628 1.588 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr18_+_57142782 1.505 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chrX_+_134308084 1.446 ENSMUST00000081064.5
ENSMUST00000101251.1
ENSMUST00000129782.1
 Cenpi


centromere protein I


chr2_+_62664279 1.437 ENSMUST00000028257.2
 Gca
grancalcin
chr7_+_79660196 1.395 ENSMUST00000035977.7
 Ticrr
TOPBP1-interacting checkpoint and replication regulator
chr8_-_89044162 1.346 ENSMUST00000034090.6
 Sall1
sal-like 1 (Drosophila)
chr18_-_78206408 1.339 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr13_-_47106176 1.318 ENSMUST00000021807.6
ENSMUST00000135278.1
 Dek

DEK oncogene (DNA binding)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 3.7 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.6 2.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 2.2 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.3 2.0 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.3 1.8 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2 1.8 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 1.7 GO:0019985 translesion synthesis(GO:0019985)
0.5 1.6 GO:0070671 monocyte extravasation(GO:0035696) activation of meiosis involved in egg activation(GO:0060466) response to interleukin-12(GO:0070671) positive regulation of acrosome reaction(GO:2000344) regulation of monocyte extravasation(GO:2000437)
0.3 1.6 GO:0021764 amygdala development(GO:0021764)
0.3 1.5 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.0 1.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 1.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.4 1.3 GO:0072092 ureteric bud invasion(GO:0072092)
0.3 1.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.3 1.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 1.3 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.0 1.2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.2 GO:0008347 glial cell migration(GO:0008347)
0.0 1.2 GO:0051489 regulation of filopodium assembly(GO:0051489)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.8 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.7 GO:0016607 nuclear speck(GO:0016607)
0.1 1.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.2 GO:0016459 myosin complex(GO:0016459)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.1 1.1 GO:0002102 podosome(GO:0002102)
0.0 1.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.0 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 0.9 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.1 0.8 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.1 0.8 GO:0042587 glycogen granule(GO:0042587)
0.1 0.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 0.7 GO:0000801 central element(GO:0000801)
0.0 0.7 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.7 GO:0005720 nuclear heterochromatin(GO:0005720)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 3.5 GO:0042393 histone binding(GO:0042393)
0.1 2.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 2.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.3 1.8 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 1.3 GO:0032027 myosin light chain binding(GO:0032027)
0.2 1.3 GO:0015265 urea channel activity(GO:0015265)
0.2 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.0 GO:0030507 spectrin binding(GO:0030507)
0.3 0.9 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.9 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.9 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.9 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)