Motif ID: Neurod2_Bhlha15_Bhlhe22_Olig1
Z-value: 0.631
Transcription factors associated with Neurod2_Bhlha15_Bhlhe22_Olig1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Bhlha15 | ENSMUSG00000052271.7 | Bhlha15 |
| Bhlhe22 | ENSMUSG00000025128.6 | Bhlhe22 |
| Neurod2 | ENSMUSG00000038255.6 | Neurod2 |
| Olig1 | ENSMUSG00000046160.5 | Olig1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Neurod2 | mm10_v2_chr11_-_98329641_98329654 | 0.54 | 4.7e-03 | Click! |
| Bhlhe22 | mm10_v2_chr3_+_18054258_18054325 | 0.50 | 9.0e-03 | Click! |
| Olig1 | mm10_v2_chr16_+_91269759_91269778 | -0.02 | 9.3e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.4 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.5 | 1.9 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.3 | 1.1 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.3 | 1.3 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.2 | 1.2 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) |
| 0.2 | 0.5 | GO:0032240 | RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.1 | 0.6 | GO:2000302 | regulation of synaptic vesicle endocytosis(GO:1900242) positive regulation of synaptic vesicle exocytosis(GO:2000302) |
| 0.1 | 0.9 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.1 | 1.1 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.1 | 1.5 | GO:0045956 | positive regulation of vesicle fusion(GO:0031340) positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.1 | 1.3 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.1 | 0.2 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 0.1 | 5.2 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.1 | 0.3 | GO:0030397 | membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081) |
| 0.1 | 0.6 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.1 | 0.2 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.1 | 0.5 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 0.2 | GO:0072070 | loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236) |
| 0.1 | 0.3 | GO:0042701 | progesterone secretion(GO:0042701) |
| 0.0 | 0.1 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.0 | 0.3 | GO:0043416 | regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 0.0 | 0.5 | GO:0070914 | nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986) UV-damage excision repair(GO:0070914) |
| 0.0 | 0.2 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.0 | 0.2 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.0 | 0.3 | GO:0061368 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.0 | 0.4 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.0 | 0.1 | GO:1903288 | regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) |
| 0.0 | 0.4 | GO:0072010 | renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
| 0.0 | 1.0 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.2 | GO:2000304 | artery smooth muscle contraction(GO:0014824) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.0 | 0.2 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.0 | 0.5 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.0 | 0.9 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.6 | GO:0001523 | retinoid metabolic process(GO:0001523) |
| 0.0 | 0.1 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
| 0.0 | 0.2 | GO:0045760 | positive regulation of action potential(GO:0045760) |
| 0.0 | 0.2 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.0 | 0.1 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 0.4 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.7 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.0 | 0.1 | GO:0046886 | positive regulation of hormone biosynthetic process(GO:0046886) |
| 0.0 | 0.1 | GO:0071397 | cellular response to cholesterol(GO:0071397) |
| 0.0 | 1.2 | GO:0046889 | positive regulation of lipid biosynthetic process(GO:0046889) |
| 0.0 | 0.1 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 0.0 | 0.1 | GO:0032796 | uropod organization(GO:0032796) |
| 0.0 | 0.2 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.2 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.1 | 0.5 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.1 | 5.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 1.1 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 1.3 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 0.2 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.0 | 0.9 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.2 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 0.2 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.0 | 0.6 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.3 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.0 | 0.1 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.0 | 1.5 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.3 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.5 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 1.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.2 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.0 | 0.5 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.9 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | GO:0045703 | pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703) |
| 0.2 | 0.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.1 | 1.2 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 0.3 | GO:0070012 | oligopeptidase activity(GO:0070012) |
| 0.1 | 0.5 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 0.7 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.1 | 2.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 1.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 0.3 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 0.2 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.0 | 0.2 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.0 | 1.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.6 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 1.0 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.2 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 0.7 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.4 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.2 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.0 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.0 | 0.1 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 0.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.2 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.1 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.0 | 0.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.2 | GO:0030275 | LRR domain binding(GO:0030275) |
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