Motif ID: Nfat5

Z-value: 0.777


Transcription factors associated with Nfat5:

Gene SymbolEntrez IDGene Name
Nfat5 ENSMUSG00000003847.10 Nfat5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293500_1072935590.106.3e-01Click!


Activity profile for motif Nfat5.

activity profile for motif Nfat5


Sorted Z-values histogram for motif Nfat5

Sorted Z-values for motif Nfat5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfat5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_82505749 3.608 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505707 3.472 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr1_+_45981548 3.309 ENSMUST00000085632.2
 Rpl23a-ps1
ribosomal protein 23A, pseudogene 1
chr4_-_138396438 2.935 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr7_-_97417730 2.747 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr5_+_139423151 2.247 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr6_-_101377897 2.101 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr7_+_99535652 2.049 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr7_+_99535439 1.919 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr3_-_95411176 1.796 ENSMUST00000177599.1
 Gm5070
predicted gene 5070
chr14_-_55116935 1.772 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr9_-_29963112 1.697 ENSMUST00000075069.4
 Ntm
neurotrimin
chr14_-_23803304 1.451 ENSMUST00000179836.1
ENSMUST00000172099.2
ENSMUST00000065788.8
ENSMUST00000179097.1
ENSMUST00000177634.1
ENSMUST00000074983.6
ENSMUST00000163322.2
ENSMUST00000100831.4
 Kcnma1







potassium large conductance calcium-activated channel, subfamily M, alpha member 1







chr5_-_104021919 1.446 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr7_+_110773658 1.432 ENSMUST00000143786.1
 Ampd3
adenosine monophosphate deaminase 3
chr5_-_104021799 1.429 ENSMUST00000119025.1
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr7_+_110774240 1.380 ENSMUST00000147587.1
 Ampd3
adenosine monophosphate deaminase 3
chr6_-_58907120 1.352 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr6_+_120773633 1.141 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr10_-_78352212 1.106 ENSMUST00000146899.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr15_-_98881255 1.102 ENSMUST00000024518.9
 Rhebl1
Ras homolog enriched in brain like 1
chr12_-_86079019 1.032 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr14_-_101609033 1.017 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chr10_-_78352053 1.008 ENSMUST00000105388.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr10_-_78351690 1.006 ENSMUST00000166360.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr14_+_17660956 0.981 ENSMUST00000022303.7
ENSMUST00000091471.4
 Thrb

thyroid hormone receptor beta

chr5_+_90772435 0.968 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr10_+_4611971 0.961 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr12_+_102948843 0.932 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr7_-_81493725 0.930 ENSMUST00000119121.1
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr7_-_80402743 0.896 ENSMUST00000122232.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr1_+_24678536 0.893 ENSMUST00000095062.3
 Lmbrd1
LMBR1 domain containing 1
chr10_-_78351711 0.853 ENSMUST00000105390.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr6_-_142964404 0.746 ENSMUST00000032421.3
 St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr2_+_68117713 0.731 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr4_+_110397764 0.724 ENSMUST00000097920.2
ENSMUST00000080744.6
 Agbl4

ATP/GTP binding protein-like 4

chr15_-_75894474 0.712 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr7_-_81493883 0.668 ENSMUST00000082090.7
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr9_+_92457369 0.668 ENSMUST00000034941.7
 Plscr4
phospholipid scramblase 4
chr16_+_92058270 0.664 ENSMUST00000047429.8
ENSMUST00000113975.2
 Mrps6
Slc5a3
mitochondrial ribosomal protein S6
solute carrier family 5 (inositol transporters), member 3
chr10_-_95415484 0.641 ENSMUST00000172070.1
ENSMUST00000150432.1
 Socs2

suppressor of cytokine signaling 2

chr7_+_6371364 0.620 ENSMUST00000086323.4
ENSMUST00000108559.2
 Zfp78

zinc finger protein 78

chrX_-_155216338 0.617 ENSMUST00000112551.3
 Sat1
spermidine/spermine N1-acetyl transferase 1
chr2_-_30415389 0.587 ENSMUST00000142096.1
 Crat
carnitine acetyltransferase
chr17_+_87107621 0.578 ENSMUST00000041369.6
 Socs5
suppressor of cytokine signaling 5
chr10_+_21994666 0.577 ENSMUST00000020145.5
 Sgk1
serum/glucocorticoid regulated kinase 1
chrX_+_123793665 0.552 ENSMUST00000178148.1
 Gm5167
predicted gene 5167
chr4_+_110397661 0.546 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr8_+_86745679 0.497 ENSMUST00000098532.2
 Gm10638
predicted gene 10638
chr10_+_84622365 0.472 ENSMUST00000077175.5
 Polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr11_-_88863717 0.458 ENSMUST00000107904.2
 Akap1
A kinase (PRKA) anchor protein 1
chr2_+_125136692 0.453 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr15_+_5185700 0.448 ENSMUST00000081640.5
 Ttc33
tetratricopeptide repeat domain 33
chr11_+_102836296 0.383 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr11_-_118401826 0.381 ENSMUST00000106290.3
ENSMUST00000043722.3
 Lgals3bp

lectin, galactoside-binding, soluble, 3 binding protein

chr2_-_30415509 0.350 ENSMUST00000134120.1
ENSMUST00000102854.3
 Crat

carnitine acetyltransferase

chr8_+_125730005 0.346 ENSMUST00000143504.1
 Ntpcr
nucleoside-triphosphatase, cancer-related
chr10_+_21993890 0.339 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr19_-_5845471 0.322 ENSMUST00000174287.1
ENSMUST00000173672.1
 Neat1

nuclear paraspeckle assembly transcript 1 (non-protein coding)

chrX_-_155216444 0.317 ENSMUST00000026318.8
 Sat1
spermidine/spermine N1-acetyl transferase 1
chr6_-_144209558 0.313 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr7_-_141918481 0.309 ENSMUST00000151890.1
 Tollip
toll interacting protein
chr6_-_144209448 0.291 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr7_-_126625676 0.291 ENSMUST00000032961.3
 Nupr1
nuclear protein transcription regulator 1
chr5_-_69592311 0.280 ENSMUST00000031117.6
 Gnpda2
glucosamine-6-phosphate deaminase 2
chr19_-_10525201 0.278 ENSMUST00000025570.6
 Sdhaf2
succinate dehydrogenase complex assembly factor 2
chr5_-_148392810 0.266 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr2_-_30415302 0.261 ENSMUST00000132981.2
ENSMUST00000129494.1
 Crat

carnitine acetyltransferase

chr18_+_36559972 0.230 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr1_+_83159733 0.210 ENSMUST00000113436.1
ENSMUST00000065436.3
ENSMUST00000065403.6
 Daw1


dynein assembly factor with WDR repeat domains 1


chr6_-_144209471 0.200 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr16_-_55838827 0.190 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr8_-_46124146 0.190 ENSMUST00000170416.1
 Snx25
sorting nexin 25
chrX_+_74429671 0.180 ENSMUST00000114127.1
ENSMUST00000064407.3
ENSMUST00000156707.1
 Ikbkg


inhibitor of kappaB kinase gamma


chr5_-_66618772 0.169 ENSMUST00000162994.1
ENSMUST00000159512.1
ENSMUST00000159786.1
 Apbb2


amyloid beta (A4) precursor protein-binding, family B, member 2


chrX_-_16817339 0.163 ENSMUST00000040820.6
 Maob
monoamine oxidase B
chr10_-_62507737 0.160 ENSMUST00000020271.6
 Srgn
serglycin
chr7_-_43533171 0.149 ENSMUST00000004728.5
ENSMUST00000039861.5
 Cd33

CD33 antigen

chr19_+_10525244 0.121 ENSMUST00000038379.3
 Cpsf7
cleavage and polyadenylation specific factor 7
chr10_-_109010955 0.094 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr10_-_95415283 0.076 ENSMUST00000119917.1
 Socs2
suppressor of cytokine signaling 2
chr2_+_176831140 0.045 ENSMUST00000122218.2
ENSMUST00000126726.1
 Gm14408

predicted gene 14408

chr12_-_83597140 0.037 ENSMUST00000048319.4
 Zfyve1
zinc finger, FYVE domain containing 1
chr13_+_73330982 0.009 ENSMUST00000022098.8
 Mrpl36
mitochondrial ribosomal protein L36
chr1_-_9944103 0.007 ENSMUST00000182498.1
ENSMUST00000182742.1
ENSMUST00000182580.1
 Snhg6


small nucleolar RNA host gene (non-protein coding) 6



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.7 2.2 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.6 4.0 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699)
0.4 1.5 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.4 2.8 GO:0032264 IMP salvage(GO:0032264)
0.3 1.0 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.3 1.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.3 1.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 0.9 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.3 2.9 GO:0042447 hormone catabolic process(GO:0042447)
0.2 1.0 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 1.0 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.2 0.9 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.2 1.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 1.0 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 0.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.6 GO:0071638 positive regulation of T-helper 1 cell differentiation(GO:0045627) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 2.7 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.1 0.9 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.7 GO:0015791 polyol transport(GO:0015791)
0.1 1.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.9 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.5 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.2 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.1 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.3 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.0 0.3 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0 2.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.7 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.9 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.3 GO:2000194 regulation of female gonad development(GO:2000194)
0.0 0.3 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.8 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 4.0 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.3 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.8 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.1 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0030314 junctional membrane complex(GO:0030314)
0.3 7.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 4.0 GO:0031143 pseudopodium(GO:0031143)
0.2 1.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 2.2 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.1 1.6 GO:1904115 axon cytoplasm(GO:1904115)
0.1 1.0 GO:0031091 platelet alpha granule(GO:0031091)
0.1 0.9 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 3.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 0.9 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 2.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.0 GO:0030315 T-tubule(GO:0030315)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.0 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 1.3 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.5 3.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.5 1.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.4 2.9 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.4 2.8 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 1.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 0.9 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.3 1.2 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.3 1.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 7.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 4.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 1.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 0.7 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.9 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.9 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.7 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 0.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.7 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 1.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.2 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 0.3 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.3 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.3 GO:0035325 Toll-like receptor binding(GO:0035325)
0.0 0.5 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.3 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)