Motif ID: Nfatc1
Z-value: 4.409
Transcription factors associated with Nfatc1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nfatc1 | ENSMUSG00000033016.9 | Nfatc1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nfatc1 | mm10_v2_chr18_-_80713062_80713080 | -0.09 | 6.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 4.3 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
0.8 | 2.3 | GO:1900158 | negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
0.7 | 2.1 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
0.6 | 1.9 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
0.5 | 6.1 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.5 | 1.9 | GO:0010838 | positive regulation of keratinocyte proliferation(GO:0010838) |
0.5 | 1.8 | GO:0032439 | endosome localization(GO:0032439) |
0.4 | 1.6 | GO:0035795 | negative regulation of mitochondrial membrane permeability(GO:0035795) |
0.4 | 3.6 | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation(GO:1904707) |
0.4 | 1.8 | GO:0001575 | globoside metabolic process(GO:0001575) |
0.3 | 1.0 | GO:0043379 | memory T cell differentiation(GO:0043379) |
0.3 | 1.1 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
0.3 | 1.6 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
0.3 | 2.1 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474) |
0.2 | 1.7 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.2 | 0.6 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
0.2 | 1.4 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
0.2 | 0.8 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
0.2 | 0.6 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
0.2 | 0.5 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) negative regulation of Fas signaling pathway(GO:1902045) |
0.2 | 1.1 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
0.1 | 1.1 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
0.1 | 0.5 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
0.1 | 0.6 | GO:0007320 | insemination(GO:0007320) |
0.1 | 0.7 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
0.1 | 0.8 | GO:0071361 | cellular response to ethanol(GO:0071361) |
0.1 | 0.5 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
0.1 | 0.6 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
0.1 | 0.2 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
0.1 | 1.0 | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
0.1 | 0.4 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
0.1 | 0.3 | GO:0044330 | canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
0.1 | 0.4 | GO:0016266 | O-glycan processing(GO:0016266) |
0.1 | 0.4 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
0.1 | 0.7 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
0.1 | 0.3 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) trigeminal ganglion development(GO:0061551) facioacoustic ganglion development(GO:1903375) |
0.1 | 0.7 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.1 | 0.7 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
0.1 | 1.1 | GO:0030575 | nuclear body organization(GO:0030575) |
0.1 | 0.4 | GO:1903887 | motile primary cilium assembly(GO:1903887) |
0.1 | 0.3 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
0.1 | 0.6 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
0.0 | 0.2 | GO:0019659 | lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
0.0 | 0.2 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
0.0 | 1.5 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 4.3 | GO:0006497 | protein lipidation(GO:0006497) |
0.0 | 0.4 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
0.0 | 0.4 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.0 | 0.5 | GO:0043586 | tongue development(GO:0043586) |
0.0 | 0.7 | GO:0030574 | collagen catabolic process(GO:0030574) |
0.0 | 0.2 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
0.0 | 0.4 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.0 | 0.3 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
0.0 | 0.3 | GO:0006020 | inositol metabolic process(GO:0006020) |
0.0 | 0.7 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
0.0 | 0.3 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
0.0 | 0.4 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 0.8 | GO:0072348 | sulfur compound transport(GO:0072348) |
0.0 | 0.5 | GO:0086036 | regulation of cardiac muscle cell membrane potential(GO:0086036) |
0.0 | 0.5 | GO:0048671 | negative regulation of collateral sprouting(GO:0048671) |
0.0 | 1.0 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
0.0 | 0.4 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
0.0 | 0.2 | GO:0018065 | protein-cofactor linkage(GO:0018065) |
0.0 | 0.4 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
0.0 | 0.1 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
0.0 | 0.5 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
0.0 | 0.6 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
0.0 | 0.3 | GO:0010640 | regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) |
0.0 | 0.8 | GO:0035058 | nonmotile primary cilium assembly(GO:0035058) |
0.0 | 341.5 | GO:0008150 | biological_process(GO:0008150) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 3.6 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
0.4 | 1.7 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.3 | 1.8 | GO:0045179 | apical cortex(GO:0045179) |
0.3 | 1.1 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
0.3 | 1.1 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
0.2 | 0.5 | GO:0000811 | GINS complex(GO:0000811) |
0.1 | 2.1 | GO:0000242 | pericentriolar material(GO:0000242) |
0.1 | 4.3 | GO:0044295 | axonal growth cone(GO:0044295) |
0.1 | 0.7 | GO:0042382 | paraspeckles(GO:0042382) |
0.1 | 1.0 | GO:0002080 | acrosomal membrane(GO:0002080) |
0.0 | 0.8 | GO:0034451 | centriolar satellite(GO:0034451) |
0.0 | 4.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
0.0 | 0.5 | GO:0017119 | Golgi transport complex(GO:0017119) |
0.0 | 0.6 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
0.0 | 0.4 | GO:0030061 | mitochondrial crista(GO:0030061) |
0.0 | 0.4 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.0 | 0.9 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.0 | 374.2 | GO:0005575 | cellular_component(GO:0005575) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.1 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.3 | 1.0 | GO:0042289 | MHC class II protein binding(GO:0042289) |
0.3 | 1.6 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
0.3 | 1.1 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
0.3 | 1.1 | GO:0035252 | UDP-xylosyltransferase activity(GO:0035252) |
0.3 | 1.6 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.3 | 2.3 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
0.2 | 1.1 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
0.2 | 1.8 | GO:0015643 | toxic substance binding(GO:0015643) |
0.2 | 4.3 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.2 | 1.9 | GO:0003680 | AT DNA binding(GO:0003680) |
0.2 | 0.7 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
0.2 | 1.1 | GO:0015616 | DNA translocase activity(GO:0015616) |
0.1 | 0.6 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
0.1 | 0.4 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
0.1 | 0.7 | GO:0043426 | MRF binding(GO:0043426) |
0.1 | 3.7 | GO:0034945 | dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595) |
0.1 | 0.5 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.1 | 3.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.1 | 0.7 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.1 | 0.4 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
0.1 | 0.8 | GO:0016920 | pyroglutamyl-peptidase activity(GO:0016920) |
0.1 | 1.0 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
0.1 | 0.5 | GO:0103116 | alpha-D-galactofuranose transporter activity(GO:0103116) |
0.1 | 1.0 | GO:0001848 | complement binding(GO:0001848) |
0.1 | 0.2 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
0.0 | 0.4 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
0.0 | 0.8 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
0.0 | 3.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 6.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.1 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.0 | 0.5 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
0.0 | 0.5 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
0.0 | 0.6 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
0.0 | 0.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.0 | 1.0 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.4 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.0 | 0.5 | GO:0005123 | death receptor binding(GO:0005123) |
0.0 | 0.7 | GO:0001968 | fibronectin binding(GO:0001968) |
0.0 | 1.3 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.0 | 0.7 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
0.0 | 0.4 | GO:0031402 | sodium ion binding(GO:0031402) |
0.0 | 0.9 | GO:0018602 | sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635) |
0.0 | 0.1 | GO:0046923 | ER retention sequence binding(GO:0046923) |
0.0 | 357.2 | GO:0003674 | molecular_function(GO:0003674) |