Motif ID: Nfatc1

Z-value: 4.409


Transcription factors associated with Nfatc1:

Gene SymbolEntrez IDGene Name
Nfatc1 ENSMUSG00000033016.9 Nfatc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc1mm10_v2_chr18_-_80713062_80713080-0.096.5e-01Click!


Activity profile for motif Nfatc1.

activity profile for motif Nfatc1


Sorted Z-values histogram for motif Nfatc1

Sorted Z-values for motif Nfatc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3000922 57.467 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3004457 56.553 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3027439 55.849 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3013140 49.679 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 48.641 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3037111 48.194 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3005125 46.724 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3025417 45.755 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3036877 45.714 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3034599 45.237 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3017408 44.090 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 39.143 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr14_-_19418930 37.932 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 34.540 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_-_98667264 31.768 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr2_+_98662227 24.816 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr9_-_13446753 6.383 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr6_+_15185203 6.087 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr11_-_11627824 5.892 ENSMUST00000081896.4
 4930512M02Rik
RIKEN cDNA 4930512M02 gene
chr14_+_120749352 5.770 ENSMUST00000138893.2
 Gm17613
predicted gene, 17613

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 341.5 GO:0008150 biological_process(GO:0008150)
0.5 6.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.4 4.3 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.0 4.3 GO:0006497 protein lipidation(GO:0006497)
0.4 3.6 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.8 2.3 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.7 2.1 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.3 2.1 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.6 1.9 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.5 1.9 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.5 1.8 GO:0032439 endosome localization(GO:0032439)
0.4 1.8 GO:0001575 globoside metabolic process(GO:0001575)
0.2 1.7 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.4 1.6 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.3 1.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 1.5 GO:0007608 sensory perception of smell(GO:0007608)
0.2 1.4 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.3 1.1 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.2 1.1 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.1 GO:0048739 cardiac muscle fiber development(GO:0048739)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 374.2 GO:0005575 cellular_component(GO:0005575)
0.0 4.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 4.3 GO:0044295 axonal growth cone(GO:0044295)
0.7 3.6 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 2.1 GO:0000242 pericentriolar material(GO:0000242)
0.3 1.8 GO:0045179 apical cortex(GO:0045179)
0.4 1.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.3 1.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 1.1 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 1.0 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.8 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.7 GO:0042382 paraspeckles(GO:0042382)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.6 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.2 0.5 GO:0000811 GINS complex(GO:0000811)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 357.2 GO:0003674 molecular_function(GO:0003674)
0.0 6.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 4.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 3.7 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.1 3.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 3.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 2.3 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.4 2.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 1.9 GO:0003680 AT DNA binding(GO:0003680)
0.2 1.8 GO:0015643 toxic substance binding(GO:0015643)
0.3 1.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 1.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 1.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.3 1.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.2 1.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.1 GO:0015616 DNA translocase activity(GO:0015616)
0.3 1.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 1.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.0 GO:0001848 complement binding(GO:0001848)