Motif ID: Nfatc2

Z-value: 1.170


Transcription factors associated with Nfatc2:

Gene SymbolEntrez IDGene Name
Nfatc2 ENSMUSG00000027544.10 Nfatc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc2mm10_v2_chr2_-_168590315_1685903720.213.1e-01Click!


Activity profile for motif Nfatc2.

activity profile for motif Nfatc2


Sorted Z-values histogram for motif Nfatc2

Sorted Z-values for motif Nfatc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 6.652 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr7_-_110061319 3.166 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr9_+_3000922 3.138 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3004457 3.056 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3027439 2.951 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr14_+_75955003 2.858 ENSMUST00000050120.2
 Kctd4
potassium channel tetramerisation domain containing 4
chr19_-_5796924 2.845 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr9_+_3036877 2.634 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3037111 2.608 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3005125 2.576 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3017408 2.548 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3013140 2.535 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 2.525 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr16_+_45093611 2.464 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr13_+_83504032 2.376 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr9_+_3034599 2.333 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3015654 2.241 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr3_-_80802789 2.227 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr9_+_3025417 2.205 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3018753 2.172 ENSMUST00000179272.1
 Gm10719
predicted gene 10719

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 248 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.2 4.7 GO:0035063 nuclear speck organization(GO:0035063)
0.9 3.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 3.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 2.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.9 2.6 GO:0007521 muscle cell fate determination(GO:0007521)
0.2 2.5 GO:0042118 endothelial cell activation(GO:0042118)
0.3 1.9 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 1.9 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 1.5 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.5 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.5 1.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.3 1.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 1.4 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 1.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 1.3 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 1.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 1.3 GO:0060074 synapse maturation(GO:0060074)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0016607 nuclear speck(GO:0016607)
0.0 5.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 3.4 GO:0005614 interstitial matrix(GO:0005614)
0.2 3.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.2 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.1 GO:0043034 costamere(GO:0043034)
0.1 1.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.8 GO:0043197 dendritic spine(GO:0043197)
0.1 1.7 GO:0071565 nBAF complex(GO:0071565)
0.1 1.7 GO:0043194 axon initial segment(GO:0043194)
0.0 1.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.4 1.2 GO:0043512 inhibin A complex(GO:0043512)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)
0.1 1.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.0 GO:0014704 intercalated disc(GO:0014704)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0001968 fibronectin binding(GO:0001968)
0.6 2.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 2.4 GO:0035198 miRNA binding(GO:0035198)
0.1 2.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 2.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.4 2.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 2.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 1.9 GO:0038191 neuropilin binding(GO:0038191)
0.4 1.8 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.3 1.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.5 1.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.3 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.3 1.2 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin binding(GO:0051378) serotonin receptor activity(GO:0099589)
0.1 1.2 GO:0097109 neuroligin family protein binding(GO:0097109)