Motif ID: Nfatc3

Z-value: 1.087


Transcription factors associated with Nfatc3:

Gene SymbolEntrez IDGene Name
Nfatc3 ENSMUSG00000031902.9 Nfatc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3mm10_v2_chr8_+_106059562_106059623-0.048.3e-01Click!


Activity profile for motif Nfatc3.

activity profile for motif Nfatc3


Sorted Z-values histogram for motif Nfatc3

Sorted Z-values for motif Nfatc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_4611971 4.497 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr18_-_80713062 2.675 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr1_-_162866502 2.572 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr11_+_63133068 2.045 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr11_+_63132569 1.744 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr15_-_79164477 1.610 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr17_-_49564262 1.525 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr9_-_58158498 1.517 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr19_+_58670358 1.382 ENSMUST00000057270.7
 Pnlip
pancreatic lipase
chr1_-_170110491 1.342 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr5_-_114273702 1.280 ENSMUST00000144050.1
ENSMUST00000044790.5
 Foxn4

forkhead box N4

chr15_+_3270767 1.270 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr14_-_16575456 1.249 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr18_-_9726670 1.095 ENSMUST00000171339.1
 Gm17430
predicted gene, 17430
chr4_-_43523595 1.080 ENSMUST00000107914.3
 Tpm2
tropomyosin 2, beta
chr7_-_134232125 0.925 ENSMUST00000127524.1
 Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr2_+_35282380 0.898 ENSMUST00000028239.6
 Gsn
gelsolin
chr16_+_43508118 0.877 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chr15_-_71954395 0.872 ENSMUST00000159410.1
 Col22a1
collagen, type XXII, alpha 1
chr7_-_134232005 0.865 ENSMUST00000134504.1
 Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.5 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 3.8 GO:0032060 bleb assembly(GO:0032060)
0.9 2.7 GO:0060854 patterning of lymph vessels(GO:0060854)
0.3 2.6 GO:0009404 toxin metabolic process(GO:0009404)
0.2 1.6 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 1.6 GO:0032808 lacrimal gland development(GO:0032808) enteric nervous system development(GO:0048484)
0.0 1.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.5 1.5 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.5 1.4 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.2 1.4 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.2 1.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 1.3 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 1.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 1.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 1.2 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.3 1.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.3 0.9 GO:1903903 striated muscle atrophy(GO:0014891) positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of establishment of T cell polarity(GO:1903903)
0.2 0.9 GO:0042758 long-chain fatty acid catabolic process(GO:0042758)
0.0 0.8 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.2 0.7 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 3.8 GO:0043218 compact myelin(GO:0043218)
0.2 1.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 1.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.5 GO:0031143 pseudopodium(GO:0031143)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 0.7 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 2.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 2.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 2.7 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)
0.5 2.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.5 GO:0008430 selenium binding(GO:0008430)
0.0 1.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.5 GO:0017124 SH3 domain binding(GO:0017124)
0.5 1.4 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.1 1.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 1.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 1.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 1.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.9 GO:0017022 myosin binding(GO:0017022)
0.1 0.8 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.1 0.8 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.8 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.2 0.7 GO:0004096 catalase activity(GO:0004096)