Motif ID: Nfe2_Bach1_Mafk

Z-value: 1.138

Transcription factors associated with Nfe2_Bach1_Mafk:

Gene SymbolEntrez IDGene Name
Bach1 ENSMUSG00000025612.5 Bach1
Mafk ENSMUSG00000018143.4 Mafk
Nfe2 ENSMUSG00000058794.6 Nfe2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafkmm10_v2_chr5_+_139791513_1397915390.809.1e-07Click!
Nfe2mm10_v2_chr15_-_103251465_103251705-0.508.8e-03Click!
Bach1mm10_v2_chr16_+_87698904_87698959-0.395.1e-02Click!


Activity profile for motif Nfe2_Bach1_Mafk.

activity profile for motif Nfe2_Bach1_Mafk


Sorted Z-values histogram for motif Nfe2_Bach1_Mafk

Sorted Z-values for motif Nfe2_Bach1_Mafk



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2_Bach1_Mafk

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 14.898 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr1_-_33907721 8.025 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr2_+_155775333 6.203 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr13_-_54611274 4.365 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr13_-_54611332 3.894 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr6_+_5725812 3.826 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr5_-_139484420 3.684 ENSMUST00000150992.1
 Zfand2a
zinc finger, AN1-type domain 2A
chr5_-_139484475 3.144 ENSMUST00000110851.1
ENSMUST00000079996.6
 Zfand2a

zinc finger, AN1-type domain 2A

chr3_-_116968827 3.049 ENSMUST00000119557.1
 Palmd
palmdelphin
chr5_-_92348871 3.037 ENSMUST00000038816.6
ENSMUST00000118006.1
 Cxcl10

chemokine (C-X-C motif) ligand 10

chr2_+_136713444 2.834 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr1_-_134235420 2.823 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr3_+_123267445 2.783 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr2_+_164948219 2.696 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr7_+_127244511 2.640 ENSMUST00000052509.4
 Zfp771
zinc finger protein 771
chr17_-_56133817 2.634 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr18_+_61045139 2.478 ENSMUST00000025522.4
ENSMUST00000115274.1
 Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr11_-_50210765 2.351 ENSMUST00000143379.1
ENSMUST00000015981.5
ENSMUST00000102774.4
 Sqstm1


sequestosome 1


chr7_-_105482197 2.132 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr2_+_25395866 2.122 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.9 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.2 8.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 7.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.6 6.5 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.5 6.2 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.8 3.8 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.4 3.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.4 3.3 GO:0005513 detection of calcium ion(GO:0005513)
0.1 3.3 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.0 3.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 3.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.9 2.8 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.7 2.8 GO:0035617 stress granule disassembly(GO:0035617)
0.2 2.8 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.9 2.7 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 2.6 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.8 2.5 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 2.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 2.2 GO:0060736 prostate gland growth(GO:0060736)
0.7 2.1 GO:0043465 regulation of fermentation(GO:0043465) negative regulation of fermentation(GO:1901003)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 18.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.7 8.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 6.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 4.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 4.4 GO:0071565 nBAF complex(GO:0071565)
0.0 4.1 GO:0005604 basement membrane(GO:0005604)
0.0 3.3 GO:0043197 dendritic spine(GO:0043197)
0.7 2.8 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.2 2.8 GO:0035253 ciliary rootlet(GO:0035253)
0.1 2.8 GO:0032279 asymmetric synapse(GO:0032279)
0.0 2.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.8 2.4 GO:0044754 amphisome(GO:0044753) autolysosome(GO:0044754)
0.2 2.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 2.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 2.1 GO:0036501 UFD1-NPL4 complex(GO:0036501)
0.1 2.1 GO:0005605 basal lamina(GO:0005605)
0.0 2.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 18.7 GO:0045503 dynein light chain binding(GO:0045503)
0.9 8.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 8.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 6.2 GO:0045296 cadherin binding(GO:0045296)
0.1 4.6 GO:0003777 microtubule motor activity(GO:0003777)
0.2 3.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
1.0 3.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 3.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 3.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.9 GO:0005057 receptor signaling protein activity(GO:0005057)
0.4 2.8 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 2.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.8 GO:0005518 collagen binding(GO:0005518)
0.7 2.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 2.7 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 2.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 2.2 GO:0005080 protein kinase C binding(GO:0005080)
0.3 2.1 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.3 2.1 GO:0043262 adenosine-diphosphatase activity(GO:0043262)