Motif ID: Nfe2l2

Z-value: 0.695


Transcription factors associated with Nfe2l2:

Gene SymbolEntrez IDGene Name
Nfe2l2 ENSMUSG00000015839.6 Nfe2l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfe2l2mm10_v2_chr2_-_75704535_757046410.164.4e-01Click!


Activity profile for motif Nfe2l2.

activity profile for motif Nfe2l2


Sorted Z-values histogram for motif Nfe2l2

Sorted Z-values for motif Nfe2l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 178 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_126799163 3.035 ENSMUST00000032934.5
 Aldoa
aldolase A, fructose-bisphosphate
chr7_-_126799134 2.547 ENSMUST00000087566.4
 Aldoa
aldolase A, fructose-bisphosphate
chrX_+_164269371 1.616 ENSMUST00000145412.1
ENSMUST00000033749.7
 Pir

pirin

chr17_+_86963279 1.351 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr7_-_17056669 1.337 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chr18_+_61639542 1.291 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr5_+_128601106 1.242 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr4_-_140774196 1.125 ENSMUST00000026381.6
 Padi4
peptidyl arginine deiminase, type IV
chr3_+_131110350 1.093 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr10_+_17796256 1.075 ENSMUST00000037964.6
 Txlnb
taxilin beta
chr2_+_153649442 1.018 ENSMUST00000072997.3
ENSMUST00000109773.1
ENSMUST00000109774.2
ENSMUST00000081628.6
ENSMUST00000103151.1
ENSMUST00000088976.5
ENSMUST00000109772.1
ENSMUST00000103150.3
ENSMUST00000056495.7
 Dnmt3b








DNA methyltransferase 3B








chrX_-_52613913 1.018 ENSMUST00000069360.7
 Gpc3
glypican 3
chr4_+_116685859 1.006 ENSMUST00000129315.1
ENSMUST00000106470.1
 Prdx1

peroxiredoxin 1

chr4_+_116685544 1.005 ENSMUST00000135573.1
ENSMUST00000151129.1
 Prdx1

peroxiredoxin 1

chrX_-_52613936 0.965 ENSMUST00000114857.1
 Gpc3
glypican 3
chr12_+_80518990 0.930 ENSMUST00000021558.6
 Galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr7_-_44997535 0.930 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr5_-_53707532 0.878 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr1_-_167285110 0.817 ENSMUST00000027839.8
 Uck2
uridine-cytidine kinase 2
chr3_+_28805436 0.817 ENSMUST00000043867.5
 Rpl22l1
ribosomal protein L22 like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 2.9 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.7 2.0 GO:0072180 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
0.2 1.7 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.1 1.6 GO:0030224 monocyte differentiation(GO:0030224)
0.1 1.4 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.2 1.2 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.4 1.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 1.1 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.3 1.0 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.3 0.9 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.0 0.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 0.8 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 0.8 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.8 GO:0032543 mitochondrial translation(GO:0032543)
0.2 0.7 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 0.7 GO:0070488 neutrophil aggregation(GO:0070488)
0.2 0.6 GO:0097278 complement-dependent cytotoxicity(GO:0097278)
0.2 0.6 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.7 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 2.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 2.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.5 GO:0016607 nuclear speck(GO:0016607)
0.1 1.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 1.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 0.8 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.6 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.6 GO:0016460 myosin II complex(GO:0016460)
0.1 0.5 GO:1990462 omegasome(GO:1990462)
0.0 0.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0031045 dense core granule(GO:0031045)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.3 GO:0000235 astral microtubule(GO:0000235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 5.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 2.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 1.7 GO:0002039 p53 binding(GO:0002039)
0.1 1.6 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.4 GO:0005522 profilin binding(GO:0005522)
0.1 1.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.1 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.2 1.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 1.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 1.1 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.0 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.9 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.2 0.8 GO:0016018 cyclosporin A binding(GO:0016018)
0.2 0.8 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.8 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.8 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.7 GO:0003688 DNA replication origin binding(GO:0003688)