Motif ID: Nfic_Nfib

Z-value: 1.754

Transcription factors associated with Nfic_Nfib:

Gene SymbolEntrez IDGene Name
Nfib ENSMUSG00000008575.11 Nfib
Nfic ENSMUSG00000055053.11 Nfic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nficmm10_v2_chr10_-_81430966_814310390.823.4e-07Click!
Nfibmm10_v2_chr4_-_82705735_827057540.644.5e-04Click!


Activity profile for motif Nfic_Nfib.

activity profile for motif Nfic_Nfib


Sorted Z-values histogram for motif Nfic_Nfib

Sorted Z-values for motif Nfic_Nfib



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfic_Nfib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_43730593 15.098 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr11_+_78324200 12.275 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr1_+_185454803 8.326 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr2_-_25469742 8.029 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 7.518 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr14_-_55116935 6.935 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr7_+_130936172 6.365 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr8_+_72646679 6.272 ENSMUST00000161386.1
ENSMUST00000093427.4
 Nwd1

NACHT and WD repeat domain containing 1

chr16_+_90831113 6.042 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr6_+_17306335 5.979 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr6_+_135362931 5.841 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr8_+_72646728 5.593 ENSMUST00000161254.1
 Nwd1
NACHT and WD repeat domain containing 1
chr7_-_79386943 5.404 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr18_-_78123324 5.295 ENSMUST00000160292.1
ENSMUST00000091813.5
 Slc14a1

solute carrier family 14 (urea transporter), member 1

chr4_+_130047840 5.207 ENSMUST00000044565.8
ENSMUST00000132251.1
 Col16a1

collagen, type XVI, alpha 1

chr11_+_78322965 5.026 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr6_-_115251839 4.454 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr7_-_97417730 4.429 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr1_-_162859684 4.411 ENSMUST00000131058.1
 Fmo1
flavin containing monooxygenase 1
chr3_+_94693556 4.379 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 17.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
3.1 15.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.9 15.1 GO:0070314 G1 to G0 transition(GO:0070314)
2.1 12.6 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
1.8 9.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
1.2 8.5 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.9 8.3 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
1.5 7.4 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
1.1 6.5 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.2 6.5 GO:0033622 integrin activation(GO:0033622)
1.1 6.4 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.9 5.6 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.8 5.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.3 4.6 GO:0060134 prepulse inhibition(GO:0060134)
0.4 4.3 GO:0009404 toxin metabolic process(GO:0009404)
0.1 4.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.4 4.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 4.2 GO:0048678 response to axon injury(GO:0048678)
0.1 4.2 GO:0048747 muscle fiber development(GO:0048747)
0.7 4.1 GO:0006570 tyrosine metabolic process(GO:0006570)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
1.8 12.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 7.8 GO:0044297 cell body(GO:0044297)
0.5 7.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 7.1 GO:0030424 axon(GO:0030424)
1.4 6.9 GO:0030314 junctional membrane complex(GO:0030314)
2.0 6.0 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
1.4 5.6 GO:0097450 astrocyte end-foot(GO:0097450)
1.8 5.3 GO:0071953 elastic fiber(GO:0071953)
0.0 5.3 GO:0043292 contractile fiber(GO:0043292)
0.0 5.3 GO:0045202 synapse(GO:0045202)
0.1 4.8 GO:0005581 collagen trimer(GO:0005581)
0.5 4.1 GO:0097449 astrocyte projection(GO:0097449)
0.1 4.0 GO:0097546 ciliary base(GO:0097546)
1.3 3.8 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.2 3.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 3.2 GO:0005901 caveola(GO:0005901)
0.2 2.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 2.8 GO:0005844 polysome(GO:0005844)
0.2 2.6 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 17.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
3.9 15.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 12.8 GO:0005178 integrin binding(GO:0005178)
0.5 12.6 GO:0051787 misfolded protein binding(GO:0051787)
0.7 9.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.4 8.5 GO:0015265 urea channel activity(GO:0015265)
0.5 8.2 GO:0008430 selenium binding(GO:0008430)
0.3 7.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.5 7.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 6.4 GO:0005080 protein kinase C binding(GO:0005080)
0.0 6.1 GO:0030246 carbohydrate binding(GO:0030246)
0.9 5.4 GO:0019841 retinol binding(GO:0019841)
0.4 5.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 5.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 4.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 4.4 GO:0030506 ankyrin binding(GO:0030506)
0.9 4.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 4.2 GO:0005504 fatty acid binding(GO:0005504)
1.0 3.8 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.1 3.5 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)