Motif ID: Nfkb2

Z-value: 0.297


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46304709_46304811-0.442.3e-02Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_33147400 0.489 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr5_+_90759299 0.328 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr15_-_102246439 0.304 ENSMUST00000063339.7
 Rarg
retinoic acid receptor, gamma
chr7_+_19176416 0.284 ENSMUST00000117338.1
 Eml2
echinoderm microtubule associated protein like 2
chr7_+_29289300 0.278 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr14_+_80000292 0.266 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chrX_+_163908982 0.253 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr5_+_110544326 0.225 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr19_+_7268296 0.223 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr19_+_6341121 0.220 ENSMUST00000025897.6
ENSMUST00000130382.1
 Map4k2

mitogen-activated protein kinase kinase kinase kinase 2

chr17_+_35424842 0.208 ENSMUST00000174699.1
 H2-Q6
histocompatibility 2, Q region locus 6
chr1_+_167001417 0.207 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr14_-_30626196 0.197 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr11_+_70029742 0.182 ENSMUST00000132597.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr17_+_35379608 0.181 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chrX_+_163909132 0.167 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr14_-_30607808 0.159 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr1_+_135132693 0.159 ENSMUST00000049449.4
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr2_-_37422869 0.158 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr11_-_84870712 0.153 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
 Ggnbp2



gametogenetin binding protein 2



chr2_-_32312162 0.150 ENSMUST00000155269.1
 Dnm1
dynamin 1
chr1_+_167001457 0.136 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr7_+_16309577 0.130 ENSMUST00000002152.6
 Bbc3
BCL2 binding component 3
chr11_-_84870646 0.126 ENSMUST00000018547.2
 Ggnbp2
gametogenetin binding protein 2
chr1_+_34801704 0.123 ENSMUST00000047664.9
 Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr5_+_37245792 0.120 ENSMUST00000031004.7
 Crmp1
collapsin response mediator protein 1
chr1_-_66817536 0.119 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr11_-_84870812 0.107 ENSMUST00000168434.1
 Ggnbp2
gametogenetin binding protein 2
chr4_-_125127817 0.106 ENSMUST00000036188.7
 Zc3h12a
zinc finger CCCH type containing 12A
chr4_+_100776664 0.105 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr14_+_55591708 0.100 ENSMUST00000019443.8
 Rnf31
ring finger protein 31
chr13_-_111490111 0.098 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490028 0.097 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr10_+_80702649 0.091 ENSMUST00000095426.3
 Izumo4
IZUMO family member 4
chr2_+_172550761 0.090 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr3_+_117575268 0.088 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr2_+_172550991 0.088 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr15_-_76918010 0.086 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr8_-_105289465 0.069 ENSMUST00000171788.1
ENSMUST00000014981.6
 4931428F04Rik

RIKEN cDNA 4931428F04 gene

chr1_+_135133272 0.069 ENSMUST00000167080.1
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr7_-_126200413 0.060 ENSMUST00000163959.1
 Xpo6
exportin 6
chr2_-_3419019 0.057 ENSMUST00000115084.1
ENSMUST00000115083.1
 Meig1

meiosis expressed gene 1

chr5_-_137531204 0.054 ENSMUST00000150063.2
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr11_-_54962903 0.054 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
 Tnip1




TNFAIP3 interacting protein 1




chr1_-_63114255 0.053 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
 Ino80d



INO80 complex subunit D



chr8_+_79028317 0.052 ENSMUST00000087927.4
ENSMUST00000098614.2
 Zfp827

zinc finger protein 827

chr16_+_32914094 0.050 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
 Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr3_+_97658212 0.049 ENSMUST00000045743.6
 Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr18_-_77565050 0.046 ENSMUST00000182153.1
ENSMUST00000182146.1
ENSMUST00000026494.7
ENSMUST00000182024.1
 Rnf165



ring finger protein 165



chr5_+_135887988 0.042 ENSMUST00000111155.1
 Hspb1
heat shock protein 1
chr11_-_84870188 0.039 ENSMUST00000154915.2
 Ggnbp2
gametogenetin binding protein 2
chr10_+_127421208 0.037 ENSMUST00000168780.1
 R3hdm2
R3H domain containing 2
chr19_-_46338632 0.034 ENSMUST00000051234.8
ENSMUST00000167861.1
 Cuedc2

CUE domain containing 2

chr10_+_59221945 0.032 ENSMUST00000182161.1
 Sowahc
sosondowah ankyrin repeat domain family member C
chr3_-_116423930 0.032 ENSMUST00000106491.2
 Cdc14a
CDC14 cell division cycle 14A
chr3_-_116424007 0.032 ENSMUST00000090464.4
 Cdc14a
CDC14 cell division cycle 14A
chr7_-_34654342 0.024 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr8_+_79028587 0.023 ENSMUST00000119254.1
 Zfp827
zinc finger protein 827
chr17_+_35866606 0.023 ENSMUST00000113814.4
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr4_-_133339238 0.020 ENSMUST00000105906.1
 Wdtc1
WD and tetratricopeptide repeats 1
chr10_-_89686250 0.020 ENSMUST00000092227.5
ENSMUST00000174252.1
 Scyl2

SCY1-like 2 (S. cerevisiae)

chr1_-_63114516 0.020 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr19_+_45015198 0.017 ENSMUST00000179108.1
 Lzts2
leucine zipper, putative tumor suppressor 2
chr5_+_125475814 0.017 ENSMUST00000031445.3
 Aacs
acetoacetyl-CoA synthetase
chr7_-_126200397 0.014 ENSMUST00000009344.9
 Xpo6
exportin 6
chr11_+_101176041 0.014 ENSMUST00000103109.3
 Cntnap1
contactin associated protein-like 1
chr11_+_77686155 0.010 ENSMUST00000100802.4
ENSMUST00000181023.1
 Nufip2

nuclear fragile X mental retardation protein interacting protein 2

chr2_-_3419066 0.009 ENSMUST00000115082.3
 Meig1
meiosis expressed gene 1
chr11_+_70657196 0.008 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr4_-_133339283 0.007 ENSMUST00000043305.7
 Wdtc1
WD and tetratricopeptide repeats 1
chr5_+_135887905 0.007 ENSMUST00000005077.6
 Hspb1
heat shock protein 1
chr10_-_59221757 0.005 ENSMUST00000165971.1
 Sept10
septin 10
chr5_-_137530990 0.003 ENSMUST00000132525.1
 Gnb2
guanine nucleotide binding protein (G protein), beta 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.3 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.1 0.3 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.4 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.1 0.2 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.0 0.1 GO:0045472 response to ether(GO:0045472) negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of tumor necrosis factor secretion(GO:1904468)
0.0 0.1 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.1 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.0 0.2 GO:1903423 positive regulation of synaptic vesicle recycling(GO:1903423)
0.0 0.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.3 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.2 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.2 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.4 GO:0036465 synaptic vesicle recycling(GO:0036465)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.3 GO:0042581 specific granule(GO:0042581)
0.0 0.0 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.2 GO:0043196 varicosity(GO:0043196)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.4 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)