Motif ID: Nhlh1

Z-value: 1.097


Transcription factors associated with Nhlh1:

Gene SymbolEntrez IDGene Name
Nhlh1 ENSMUSG00000051251.3 Nhlh1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nhlh1mm10_v2_chr1_-_172057573_172057598-0.048.4e-01Click!


Activity profile for motif Nhlh1.

activity profile for motif Nhlh1


Sorted Z-values histogram for motif Nhlh1

Sorted Z-values for motif Nhlh1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nhlh1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_147188678 2.926 ENSMUST00000065382.5
 Gsx1
GS homeobox 1
chr16_+_91269759 2.457 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr7_+_122289297 1.908 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chrX_+_35888808 1.741 ENSMUST00000033419.6
 Dock11
dedicator of cytokinesis 11
chr7_-_28302238 1.701 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr13_-_111808938 1.673 ENSMUST00000109267.2
 Map3k1
mitogen-activated protein kinase kinase kinase 1
chr2_+_70562007 1.545 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr2_+_102658640 1.532 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_-_34882919 1.462 ENSMUST00000098163.2
ENSMUST00000047950.5
 Zfp292

zinc finger protein 292

chr9_+_83834684 1.307 ENSMUST00000070326.7
 Ttk
Ttk protein kinase
chr3_-_66981279 1.296 ENSMUST00000162098.2
 Shox2
short stature homeobox 2
chr4_+_45184815 1.290 ENSMUST00000134280.1
ENSMUST00000044773.5
 Frmpd1

FERM and PDZ domain containing 1

chr14_+_56887795 1.285 ENSMUST00000022511.8
 Zmym2
zinc finger, MYM-type 2
chr9_+_67840386 1.203 ENSMUST00000077879.5
 Vps13c
vacuolar protein sorting 13C (yeast)
chr12_-_119238794 1.178 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr1_+_174501796 1.137 ENSMUST00000030039.7
 Fmn2
formin 2
chr10_+_94514825 1.083 ENSMUST00000065060.5
 Tmcc3
transmembrane and coiled coil domains 3
chrX_+_110814390 1.073 ENSMUST00000078229.3
 Pou3f4
POU domain, class 3, transcription factor 4
chr6_-_56362356 1.068 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr8_+_12385769 1.009 ENSMUST00000080795.8
 Gm5607
predicted gene 5607

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 393 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.3 2.5 GO:0021984 adenohypophysis development(GO:0021984)
0.0 2.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 2.2 GO:0007386 compartment pattern specification(GO:0007386)
0.7 2.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.0 2.0 GO:2001222 regulation of neuron migration(GO:2001222)
0.3 1.9 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.4 1.8 GO:0046469 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.2 1.7 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.1 1.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 1.7 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.7 GO:0048709 oligodendrocyte differentiation(GO:0048709)
0.1 1.6 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 1.6 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.5 1.5 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.3 1.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 1.5 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 1.5 GO:0051304 chromosome separation(GO:0051304)
0.2 1.4 GO:0090383 phagosome acidification(GO:0090383)
0.0 1.4 GO:1902476 chloride transmembrane transport(GO:1902476)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.6 GO:0060077 inhibitory synapse(GO:0060077)
0.1 2.8 GO:0031941 filamentous actin(GO:0031941)
0.1 2.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.7 GO:0016605 PML body(GO:0016605)
0.0 2.5 GO:0005604 basement membrane(GO:0005604)
0.2 1.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.8 GO:0030027 lamellipodium(GO:0030027)
0.0 1.7 GO:0005902 microvillus(GO:0005902)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.0 1.5 GO:0000776 kinetochore(GO:0000776)
0.0 1.4 GO:0005871 kinesin complex(GO:0005871)
0.2 1.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.3 GO:0034451 centriolar satellite(GO:0034451)
0.4 1.2 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 1.2 GO:0005605 basal lamina(GO:0005605)
0.0 1.2 GO:0090544 BAF-type complex(GO:0090544)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.1 1.1 GO:0070531 BRCA1-A complex(GO:0070531)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 3.5 GO:0005112 Notch binding(GO:0005112)
0.0 3.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.3 GO:0008017 microtubule binding(GO:0008017)
0.4 3.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 1.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.4 1.8 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.2 1.7 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 1.7 GO:0046625 sphingolipid binding(GO:0046625)
0.0 1.7 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 1.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 1.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 1.6 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) 3,4-dihydrocoumarin hydrolase activity(GO:0018733) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.4 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.4 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.3 GO:0003774 motor activity(GO:0003774)
0.3 1.2 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.3 1.2 GO:0004064 arylesterase activity(GO:0004064)