Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.500

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2






Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_55782500 4.659 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr6_-_23248264 2.726 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr6_-_124779686 1.969 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr13_-_102905740 1.761 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102906046 1.701 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr3_-_116424007 1.337 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr17_-_34000257 1.252 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
H2-K1




histocompatibility 2, K1, K region




chr11_+_43681998 1.228 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr11_+_43682038 1.224 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr3_-_116423930 1.168 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr4_-_140774196 0.979 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr6_+_29694204 0.948 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33

chr16_+_52031549 0.919 ENSMUST00000114471.1
Cblb
Casitas B-lineage lymphoma b
chr11_-_87108656 0.878 ENSMUST00000051395.8
Prr11
proline rich 11
chr5_+_103425181 0.871 ENSMUST00000048957.9
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr8_-_3694167 0.867 ENSMUST00000005678.4
Fcer2a
Fc receptor, IgE, low affinity II, alpha polypeptide
chr5_+_140607334 0.836 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_+_29983948 0.809 ENSMUST00000148442.1
Zfp568
zinc finger protein 568
chr4_-_132075250 0.725 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr9_-_100486788 0.691 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0043010 camera-type eye development(GO:0043010)
0.0 3.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.5 2.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 2.5 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.2 1.3 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 1.0 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.3 0.9 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.3 0.9 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.2 0.9 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.9 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.2 0.8 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.8 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 0.7 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.1 0.6 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 0.6 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.6 GO:0007530 sex determination(GO:0007530)
0.0 0.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.5 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.4 GO:0090365 regulation of mRNA modification(GO:0090365)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.2 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.2 1.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 0.9 GO:0019863 IgE binding(GO:0019863)
0.1 0.9 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 0.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.5 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 0.3 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.3 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)