Motif ID: Nkx2-1
Z-value: 0.734
Transcription factors associated with Nkx2-1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-1 | ENSMUSG00000001496.9 | Nkx2-1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-1 | mm10_v2_chr12_-_56535047_56535106 | 0.62 | 6.7e-04 | Click! |
Top targets:
Showing 1 to 20 of 104 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 44 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | GO:0006814 | sodium ion transport(GO:0006814) |
| 0.5 | 4.1 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.2 | 3.8 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
| 0.6 | 3.7 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.5 | 3.3 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.3 | 2.7 | GO:0060179 | male mating behavior(GO:0060179) |
| 0.6 | 2.6 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.2 | 1.9 | GO:0032306 | regulation of prostaglandin secretion(GO:0032306) embryonic process involved in female pregnancy(GO:0060136) |
| 0.2 | 1.9 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.2 | 1.7 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.0 | 1.7 | GO:2000179 | positive regulation of neural precursor cell proliferation(GO:2000179) |
| 0.5 | 1.5 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 0.1 | 1.4 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.3 | 1.2 | GO:0002339 | B cell selection(GO:0002339) |
| 0.1 | 1.2 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.1 | 1.1 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.1 | 1.1 | GO:0051573 | negative regulation of histone H3-K9 methylation(GO:0051573) |
| 0.3 | 1.0 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.3 | 0.9 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.0 | 0.9 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
Gene overrepresentation in cellular_component category:
Showing 1 to 17 of 17 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 0.2 | 1.9 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.1 | 1.7 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 1.4 | GO:0032039 | integrator complex(GO:0032039) |
| 0.2 | 1.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 1.2 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.1 | 1.1 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.1 | 1.0 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.2 | 0.9 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 0.5 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.3 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 0.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.2 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.2 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 0.2 | GO:0001527 | microfibril(GO:0001527) |
| 0.0 | 0.1 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.1 | GO:0030056 | hemidesmosome(GO:0030056) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 30 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.2 | 6.1 | GO:0005272 | sodium channel activity(GO:0005272) |
| 0.2 | 4.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 3.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.5 | 2.6 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.2 | 1.9 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 1.7 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 1.5 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 1.4 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.2 | 1.3 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
| 0.1 | 1.2 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 1.1 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.1 | 1.1 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.0 | 1.1 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 1.0 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.9 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.1 | 0.8 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 0.8 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 0.8 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
| 0.0 | 0.6 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
