Motif ID: Nkx2-1

Z-value: 0.734


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56535047_565351060.626.7e-04Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_128601106 4.130 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr12_+_103314944 4.124 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr8_-_46294592 3.812 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr13_-_71963713 3.473 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr1_+_75450436 3.058 ENSMUST00000113577.1
 Asic4
acid-sensing (proton-gated) ion channel family member 4
chr1_+_75450699 3.013 ENSMUST00000037708.9
 Asic4
acid-sensing (proton-gated) ion channel family member 4
chr4_+_89688196 2.675 ENSMUST00000052478.2
 Dmrta1
doublesex and mab-3 related transcription factor like family A1
chr1_+_12718496 2.557 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chrX_+_58030999 1.864 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chrX_-_142390334 1.852 ENSMUST00000112907.1
 Acsl4
acyl-CoA synthetase long-chain family member 4
chrX_+_58030622 1.844 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr14_-_47411666 1.749 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr19_+_44493472 1.742 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr11_+_117849223 1.714 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr16_+_48994185 1.701 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr11_+_117849286 1.541 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr10_+_88091070 1.516 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr2_+_121506715 1.466 ENSMUST00000028676.5
 Wdr76
WD repeat domain 76
chr2_+_121506748 1.330 ENSMUST00000099473.3
ENSMUST00000110602.2
 Wdr76

WD repeat domain 76

chr4_+_98923845 1.306 ENSMUST00000091358.4
 Usp1
ubiquitin specific peptidase 1
chr12_+_78748947 1.243 ENSMUST00000082024.5
 Mpp5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chrX_-_111463103 1.202 ENSMUST00000137712.2
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr17_+_34263209 1.168 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr4_-_44704006 1.148 ENSMUST00000146335.1
 Pax5
paired box gene 5
chr1_+_97024681 1.111 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr2_-_170406501 1.093 ENSMUST00000154650.1
 Bcas1
breast carcinoma amplified sequence 1
chrX_+_100730178 1.086 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr1_-_181842334 1.075 ENSMUST00000005003.6
 Lbr
lamin B receptor
chr9_-_71896047 1.047 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr15_-_10470490 1.006 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr2_+_80315461 1.004 ENSMUST00000028392.7
 Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr4_+_45203921 0.919 ENSMUST00000107804.1
 Frmpd1
FERM and PDZ domain containing 1
chr17_+_47737030 0.902 ENSMUST00000086932.3
 Tfeb
transcription factor EB
chr4_-_9643638 0.878 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
 Asph




aspartate-beta-hydroxylase




chr2_-_57114970 0.832 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr4_-_21685782 0.827 ENSMUST00000076206.4
 Prdm13
PR domain containing 13
chr12_-_30911593 0.806 ENSMUST00000062740.7
ENSMUST00000074038.5
 Acp1

acid phosphatase 1, soluble

chr1_-_163725123 0.778 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr9_+_75775355 0.767 ENSMUST00000012281.7
 Bmp5
bone morphogenetic protein 5
chr17_-_34627365 0.755 ENSMUST00000064953.8
ENSMUST00000170345.1
ENSMUST00000171121.2
ENSMUST00000168391.2
ENSMUST00000169067.2
 Ppt2




palmitoyl-protein thioesterase 2




chrX_-_111463043 0.737 ENSMUST00000065976.5
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr11_-_86257553 0.724 ENSMUST00000132024.1
ENSMUST00000139285.1
 Ints2

integrator complex subunit 2

chr17_-_25861456 0.678 ENSMUST00000079461.8
ENSMUST00000176923.1
 Wdr90

WD repeat domain 90

chr11_-_86257518 0.669 ENSMUST00000136469.1
ENSMUST00000018212.6
 Ints2

integrator complex subunit 2

chr1_+_135232045 0.627 ENSMUST00000110798.3
 Gm4204
predicted gene 4204
chr13_+_55635002 0.602 ENSMUST00000172272.1
ENSMUST00000099479.3
 Ddx46

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

chr16_-_76403673 0.600 ENSMUST00000052867.7
 Gm9843
predicted gene 9843
chr7_+_51879041 0.568 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr10_+_22645011 0.559 ENSMUST00000042261.4
 Slc2a12
solute carrier family 2 (facilitated glucose transporter), member 12
chr16_+_44139821 0.528 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
 Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr17_-_34628005 0.527 ENSMUST00000166040.2
 Ppt2
palmitoyl-protein thioesterase 2
chr7_+_51878967 0.526 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr4_-_141874879 0.519 ENSMUST00000036854.3
 Efhd2
EF hand domain containing 2
chr11_-_78550777 0.510 ENSMUST00000103242.4
 Tmem97
transmembrane protein 97
chr2_-_121235689 0.443 ENSMUST00000142400.1
 Trp53bp1
transformation related protein 53 binding protein 1
chr11_+_94741782 0.442 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr18_+_49832622 0.384 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr10_-_123196916 0.376 ENSMUST00000020334.7
 Usp15
ubiquitin specific peptidase 15
chr3_-_108200807 0.375 ENSMUST00000106655.1
ENSMUST00000065664.6
 Cyb561d1

cytochrome b-561 domain containing 1

chrX_+_7762652 0.334 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
 Tfe3



transcription factor E3



chr7_+_35397046 0.333 ENSMUST00000079414.5
 Cep89
centrosomal protein 89
chr15_+_99702278 0.310 ENSMUST00000023759.4
 Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr4_+_62360695 0.299 ENSMUST00000084526.5
 Slc31a1
solute carrier family 31, member 1
chr5_-_110779937 0.298 ENSMUST00000112426.1
 Pus1
pseudouridine synthase 1
chr4_+_120854786 0.293 ENSMUST00000071093.2
 Rims3
regulating synaptic membrane exocytosis 3
chr13_+_12565868 0.280 ENSMUST00000071973.6
 Ero1lb
ERO1-like beta (S. cerevisiae)
chr8_-_83442648 0.275 ENSMUST00000167525.1
 Scoc
short coiled-coil protein
chr5_+_30105161 0.257 ENSMUST00000058045.4
 Gareml
GRB2 associated, regulator of MAPK1-like
chr9_+_119937606 0.239 ENSMUST00000035100.5
 Ttc21a
tetratricopeptide repeat domain 21A
chr17_-_32388885 0.238 ENSMUST00000087703.5
ENSMUST00000170603.1
 Wiz

widely-interspaced zinc finger motifs

chr2_-_158146385 0.235 ENSMUST00000103122.3
 Tgm2
transglutaminase 2, C polypeptide
chr2_+_69897220 0.234 ENSMUST00000055758.9
ENSMUST00000112251.2
 Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr11_+_70432627 0.223 ENSMUST00000084954.6
ENSMUST00000108568.3
ENSMUST00000079056.2
ENSMUST00000102564.4
ENSMUST00000124943.1
ENSMUST00000150076.1
ENSMUST00000102563.1
 Arrb2






arrestin, beta 2






chrX_+_56963325 0.216 ENSMUST00000096431.3
 Gpr112
G protein-coupled receptor 112
chr11_+_80428598 0.212 ENSMUST00000173938.1
ENSMUST00000017572.7
 Psmd11

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

chr11_+_100622971 0.171 ENSMUST00000142993.1
 Nkiras2
NFKB inhibitor interacting Ras-like protein 2
chr2_+_80638798 0.154 ENSMUST00000028382.6
ENSMUST00000124377.1
 Nup35

nucleoporin 35

chr6_+_59208870 0.147 ENSMUST00000062626.3
 Tigd2
tigger transposable element derived 2
chr8_+_23411490 0.137 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chr11_-_120086790 0.133 ENSMUST00000106227.1
ENSMUST00000106229.1
ENSMUST00000180242.1
 Azi1


5-azacytidine induced gene 1


chr2_+_71786923 0.123 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr2_-_121506639 0.116 ENSMUST00000089926.5
 Mfap1a
microfibrillar-associated protein 1A
chr4_-_41517326 0.110 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr5_-_115341142 0.106 ENSMUST00000139167.1
 Gatc
glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)
chr17_-_56982120 0.101 ENSMUST00000056113.4
 Acer1
alkaline ceramidase 1
chr1_-_54194048 0.095 ENSMUST00000120904.1
 Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr17_-_34628380 0.089 ENSMUST00000167097.2
 Ppt2
palmitoyl-protein thioesterase 2
chr9_+_46012810 0.076 ENSMUST00000126865.1
 Sik3
SIK family kinase 3
chr2_-_121473993 0.074 ENSMUST00000056732.3
 Mfap1b
microfibrillar-associated protein 1B
chr1_-_162898665 0.066 ENSMUST00000111510.1
ENSMUST00000045902.6
 Fmo2

flavin containing monooxygenase 2

chr7_-_28372233 0.059 ENSMUST00000094644.4
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr7_-_28372597 0.058 ENSMUST00000144700.1
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr1_+_153900572 0.044 ENSMUST00000139476.1
 Glul
glutamate-ammonia ligase (glutamine synthetase)
chr17_-_36951636 0.041 ENSMUST00000040402.7
ENSMUST00000174711.1
 Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

chr1_+_63176818 0.041 ENSMUST00000129339.1
 Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr4_-_118490030 0.039 ENSMUST00000047421.5
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr7_+_128246812 0.033 ENSMUST00000164710.1
ENSMUST00000070656.5
 Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr9_+_46012822 0.030 ENSMUST00000120463.2
ENSMUST00000120247.1
 Sik3

SIK family kinase 3

chr2_-_103797617 0.024 ENSMUST00000028607.6
 Caprin1
cell cycle associated protein 1
chr3_+_37420273 0.015 ENSMUST00000029277.8
 Spata5
spermatogenesis associated 5
chr15_+_80234071 0.013 ENSMUST00000023048.4
ENSMUST00000166030.1
 Mief1

mitochondrial elongation factor 1

chr7_+_128246953 0.011 ENSMUST00000167965.1
 Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr4_+_9269285 0.007 ENSMUST00000038841.7
 Clvs1
clavesin 1
chr3_-_150073620 0.006 ENSMUST00000057740.5
 Rpsa-ps10
ribosomal protein SA, pseudogene 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.6 3.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.5 4.1 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.5 1.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.5 3.3 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.3 0.9 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.3 1.2 GO:0002339 B cell selection(GO:0002339)
0.3 2.7 GO:0060179 male mating behavior(GO:0060179)
0.3 1.0 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 3.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.2 0.8 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 1.9 GO:0032306 regulation of prostaglandin secretion(GO:0032306) embryonic process involved in female pregnancy(GO:0060136)
0.2 1.7 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.2 1.9 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.2 0.8 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.1 0.1 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1 1.1 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.3 GO:0072718 response to cisplatin(GO:0072718)
0.1 0.3 GO:0030070 insulin processing(GO:0030070)
0.1 0.6 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 0.2 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 0.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 1.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 1.4 GO:0016180 snRNA processing(GO:0016180)
0.1 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 1.1 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.0 0.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.2 GO:0034392 positive regulation of synaptic transmission, dopaminergic(GO:0032226) negative regulation of smooth muscle cell apoptotic process(GO:0034392) follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.1 GO:0035878 nail development(GO:0035878)
0.0 5.8 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 1.7 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.2 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.0 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.0 0.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.8 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.6 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.3 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.2 1.9 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.2 0.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 1.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 1.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.4 GO:0032039 integrator complex(GO:0032039)
0.1 1.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.2 GO:0031762 alpha-1A adrenergic receptor binding(GO:0031691) alpha-1B adrenergic receptor binding(GO:0031692) follicle-stimulating hormone receptor binding(GO:0031762)
0.2 6.1 GO:0005272 sodium channel activity(GO:0005272)
0.2 4.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.3 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.2 1.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 1.2 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 3.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.8 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.6 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.1 GO:0071633 dihydroceramidase activity(GO:0071633)
0.0 1.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 12.7 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 0.3 GO:0034951 pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)
0.0 0.1 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.0 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.8 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.9 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.4 GO:0042162 telomeric DNA binding(GO:0042162)