Motif ID: Nkx2-2

Z-value: 1.174


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_1471864130.096.6e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_88091070 4.621 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr9_+_72438534 2.880 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr14_-_19418930 2.813 ENSMUST00000177817.1
Gm21738
predicted gene, 21738
chr9_+_3018753 2.784 ENSMUST00000179272.1
Gm10719
predicted gene 10719
chr9_+_72438519 2.667 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr9_+_3034599 2.657 ENSMUST00000178641.1
Gm17535
predicted gene, 17535
chr9_+_3005125 2.552 ENSMUST00000179881.1
Gm11168
predicted gene 11168
chr9_+_3015654 2.442 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr2_-_140170528 2.324 ENSMUST00000046030.7
Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr6_+_5390387 2.307 ENSMUST00000183358.1
Asb4
ankyrin repeat and SOCS box-containing 4
chr9_+_3025417 2.302 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr9_+_3017408 2.289 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr11_+_78301529 2.175 ENSMUST00000045026.3
Spag5
sperm associated antigen 5
chr4_+_59626189 2.007 ENSMUST00000070150.4
ENSMUST00000052420.6
E130308A19Rik

RIKEN cDNA E130308A19 gene

chr9_-_8004585 1.918 ENSMUST00000086580.5
ENSMUST00000065353.6
Yap1

yes-associated protein 1

chrX_+_9885622 1.836 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5

synaptotagmin-like 5

chr13_+_33964659 1.780 ENSMUST00000021843.5
ENSMUST00000058978.7
Nqo2

NAD(P)H dehydrogenase, quinone 2

chr3_+_5218516 1.756 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr10_-_12861735 1.734 ENSMUST00000076817.4
Utrn
utrophin
chr10_+_22360552 1.720 ENSMUST00000182677.1
Raet1d
retinoic acid early transcript delta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.3 5.5 GO:0070986 left/right axis specification(GO:0070986)
1.5 4.6 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.3 2.7 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.1 2.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.6 2.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 2.3 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 2.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.4 1.9 GO:0060242 contact inhibition(GO:0060242)
0.2 1.8 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 1.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.6 1.7 GO:0007525 somatic muscle development(GO:0007525)
0.1 1.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.4 1.6 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 1.5 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.5 1.4 GO:0046078 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
0.4 1.3 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.3 1.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.2 1.3 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.9 GO:0005730 nucleolus(GO:0005730)
0.1 5.5 GO:0005882 intermediate filament(GO:0005882)
0.0 4.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.4 GO:0034451 centriolar satellite(GO:0034451)
0.6 2.5 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.6 2.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.9 GO:0005902 microvillus(GO:0005902)
0.6 1.7 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 1.7 GO:0070938 contractile ring(GO:0070938)
0.1 1.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 1.3 GO:0001940 male pronucleus(GO:0001940)
0.3 1.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 1.2 GO:0031526 brush border membrane(GO:0031526)
0.0 1.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 1.1 GO:0070578 RISC-loading complex(GO:0070578)
0.1 1.1 GO:0001650 fibrillar center(GO:0001650)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.3 1.0 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 1.0 GO:0035253 ciliary rootlet(GO:0035253)
0.2 0.9 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 GO:0000049 tRNA binding(GO:0000049)
0.2 4.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 3.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.9 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 1.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.7 GO:0017166 vinculin binding(GO:0017166)
0.0 1.5 GO:0051015 actin filament binding(GO:0051015)
0.1 1.4 GO:0005542 folic acid binding(GO:0005542)
0.1 1.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 1.2 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.2 1.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 1.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 1.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 1.1 GO:0045502 dynein binding(GO:0045502)
0.3 1.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 1.0 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)