Motif ID: Nkx2-3

Z-value: 0.747


Transcription factors associated with Nkx2-3:

Gene SymbolEntrez IDGene Name
Nkx2-3 ENSMUSG00000044220.12 Nkx2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_43612325-0.086.9e-01Click!


Activity profile for motif Nkx2-3.

activity profile for motif Nkx2-3


Sorted Z-values histogram for motif Nkx2-3

Sorted Z-values for motif Nkx2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_38783503 5.052 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr12_+_38783455 4.140 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr15_+_92597104 2.015 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr2_+_73271925 1.648 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr12_+_38780284 1.596 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr2_-_114013619 1.567 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr11_-_98053415 1.496 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr1_-_45890078 1.490 ENSMUST00000183590.1
 Gm5269
predicted gene 5269
chr7_-_19699008 1.454 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr12_+_38780817 1.436 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr5_-_62766153 1.424 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_136171722 1.416 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr16_+_7069825 1.415 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chrX_-_139714481 1.395 ENSMUST00000183728.1
 Gm15013
predicted gene 15013
chr3_+_55461758 1.393 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr15_+_99006056 1.324 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr13_+_83504032 1.295 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_+_19103022 1.214 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr1_-_78968079 1.152 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr6_-_6882068 1.074 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.7 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.6 GO:0007601 visual perception(GO:0007601)
0.5 1.5 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.1 1.5 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 1.4 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 1.4 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 1.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.4 1.3 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 1.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.3 1.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.4 1.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.4 1.1 GO:0060166 olfactory pit development(GO:0060166)
0.1 1.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 1.0 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 1.0 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.2 0.9 GO:0006538 glutamate catabolic process(GO:0006538)
0.2 0.9 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.1 0.9 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.8 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 0.7 GO:0046684 response to pyrethroid(GO:0046684)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.6 1.7 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.5 1.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 1.5 GO:0030673 axolemma(GO:0030673)
0.2 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 1.1 GO:0071565 nBAF complex(GO:0071565)
0.1 1.0 GO:0031045 dense core granule(GO:0031045)
0.1 0.9 GO:0005922 connexon complex(GO:0005922)
0.0 0.9 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 0.6 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640) sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 1.5 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 1.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.4 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 1.3 GO:0003680 AT DNA binding(GO:0003680)
0.2 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.1 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 1.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 0.9 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.9 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 0.9 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 0.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.7 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)