Motif ID: Nkx2-3
Z-value: 0.747
Transcription factors associated with Nkx2-3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx2-3 | ENSMUSG00000044220.12 | Nkx2-3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx2-3 | mm10_v2_chr19_+_43612299_43612325 | -0.08 | 6.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:2001139 | negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139) |
0.4 | 1.3 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
0.4 | 12.7 | GO:0007638 | mechanosensory behavior(GO:0007638) |
0.4 | 1.1 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
0.4 | 1.1 | GO:0060166 | olfactory pit development(GO:0060166) |
0.3 | 1.2 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
0.2 | 0.5 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
0.2 | 0.9 | GO:0006538 | glutamate catabolic process(GO:0006538) |
0.2 | 0.9 | GO:1901204 | positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204) |
0.2 | 0.5 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
0.2 | 0.5 | GO:0097114 | NMDA glutamate receptor clustering(GO:0097114) |
0.1 | 1.3 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
0.1 | 1.0 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.1 | 0.6 | GO:0032512 | regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
0.1 | 0.7 | GO:0046684 | response to pyrethroid(GO:0046684) |
0.1 | 0.4 | GO:0006642 | triglyceride mobilization(GO:0006642) |
0.1 | 1.0 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
0.1 | 0.9 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
0.1 | 0.3 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
0.1 | 0.5 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
0.1 | 0.3 | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
0.1 | 0.6 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 1.4 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
0.1 | 0.3 | GO:0021759 | globus pallidus development(GO:0021759) |
0.1 | 1.5 | GO:0021860 | pyramidal neuron development(GO:0021860) |
0.1 | 0.8 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
0.1 | 1.4 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
0.1 | 0.6 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
0.1 | 0.4 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
0.1 | 0.1 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) |
0.1 | 0.6 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.1 | 0.2 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.1 | 0.6 | GO:0009404 | toxin metabolic process(GO:0009404) |
0.1 | 0.2 | GO:0003289 | atrial septum primum morphogenesis(GO:0003289) noradrenergic neuron differentiation(GO:0003357) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
0.1 | 0.3 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
0.1 | 0.4 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
0.0 | 0.2 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
0.0 | 0.3 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
0.0 | 0.4 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
0.0 | 0.4 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
0.0 | 0.1 | GO:0060023 | soft palate development(GO:0060023) |
0.0 | 0.2 | GO:0034285 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
0.0 | 0.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.0 | 0.4 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.0 | 0.5 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.0 | 0.1 | GO:0009838 | abscission(GO:0009838) |
0.0 | 1.4 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
0.0 | 0.2 | GO:0030242 | pexophagy(GO:0030242) |
0.0 | 0.2 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
0.0 | 0.2 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
0.0 | 0.7 | GO:0015701 | bicarbonate transport(GO:0015701) |
0.0 | 0.2 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
0.0 | 0.3 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
0.0 | 0.3 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
0.0 | 0.6 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
0.0 | 0.2 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
0.0 | 0.6 | GO:0048670 | regulation of collateral sprouting(GO:0048670) |
0.0 | 0.1 | GO:0045472 | response to ether(GO:0045472) |
0.0 | 0.3 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
0.0 | 0.5 | GO:0007097 | nuclear migration(GO:0007097) |
0.0 | 0.1 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
0.0 | 0.3 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) cellular response to magnesium ion(GO:0071286) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.0 | 0.6 | GO:0035455 | response to interferon-alpha(GO:0035455) |
0.0 | 0.2 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
0.0 | 0.4 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
0.0 | 0.1 | GO:0010871 | negative regulation of receptor biosynthetic process(GO:0010871) |
0.0 | 0.1 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
0.0 | 0.1 | GO:0090148 | membrane fission(GO:0090148) |
0.0 | 0.1 | GO:0035063 | nuclear speck organization(GO:0035063) |
0.0 | 0.3 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
0.0 | 0.1 | GO:0015867 | ATP transport(GO:0015867) |
0.0 | 1.6 | GO:0007601 | visual perception(GO:0007601) |
0.0 | 1.0 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
0.0 | 0.1 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.0 | 0.3 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
0.0 | 0.3 | GO:0061050 | regulation of cell growth involved in cardiac muscle cell development(GO:0061050) |
0.0 | 0.5 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
0.0 | 0.1 | GO:0033572 | transferrin transport(GO:0033572) |
0.0 | 0.3 | GO:0060074 | synapse maturation(GO:0060074) |
0.0 | 0.3 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
0.0 | 0.4 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.0 | 0.1 | GO:0090188 | negative regulation of pancreatic juice secretion(GO:0090188) |
0.0 | 0.1 | GO:0035584 | calcium-mediated signaling using intracellular calcium source(GO:0035584) |
0.0 | 0.4 | GO:0021954 | central nervous system neuron development(GO:0021954) |
0.0 | 0.3 | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 1.7 | GO:0005595 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
0.5 | 1.5 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
0.2 | 1.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.2 | 0.6 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
0.1 | 2.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.1 | 0.7 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.1 | 1.2 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
0.1 | 0.3 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
0.1 | 0.8 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.1 | 1.0 | GO:0031045 | dense core granule(GO:0031045) |
0.1 | 0.9 | GO:0005922 | connexon complex(GO:0005922) |
0.1 | 0.2 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.1 | 0.7 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.0 | 0.3 | GO:0036157 | outer dynein arm(GO:0036157) |
0.0 | 1.1 | GO:0071565 | nBAF complex(GO:0071565) |
0.0 | 1.5 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.7 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.0 | 0.6 | GO:0005640 | nuclear outer membrane(GO:0005640) sarcoplasmic reticulum membrane(GO:0033017) |
0.0 | 0.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.9 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.0 | 0.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.0 | 0.9 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.0 | 0.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.0 | 0.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.1 | GO:0034684 | integrin alphav-beta5 complex(GO:0034684) |
0.0 | 0.6 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
0.0 | 0.3 | GO:0005614 | interstitial matrix(GO:0005614) |
0.0 | 0.3 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.0 | 1.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
0.0 | 0.1 | GO:0090543 | Flemming body(GO:0090543) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
0.3 | 1.0 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
0.3 | 0.9 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
0.2 | 0.7 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
0.2 | 1.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.1 | 1.4 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
0.1 | 0.4 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
0.1 | 0.9 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
0.1 | 1.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.1 | 1.3 | GO:0003680 | AT DNA binding(GO:0003680) |
0.1 | 0.6 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.1 | 0.3 | GO:0036004 | GAF domain binding(GO:0036004) |
0.1 | 0.8 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.1 | 0.4 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
0.1 | 0.4 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
0.1 | 0.2 | GO:0001851 | complement component C3b binding(GO:0001851) |
0.1 | 0.9 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
0.1 | 0.4 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.1 | 0.6 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
0.1 | 0.6 | GO:0043495 | protein anchor(GO:0043495) |
0.1 | 0.5 | GO:0050693 | LBD domain binding(GO:0050693) |
0.1 | 0.3 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.1 | 1.5 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.1 | 0.9 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
0.1 | 0.4 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
0.1 | 0.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.1 | 0.4 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.1 | 0.1 | GO:0031490 | chromatin DNA binding(GO:0031490) |
0.0 | 0.3 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
0.0 | 1.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.2 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
0.0 | 1.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.2 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
0.0 | 0.2 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
0.0 | 11.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.0 | 0.5 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.0 | 1.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.0 | 0.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
0.0 | 1.1 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.0 | 1.0 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 0.1 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
0.0 | 0.7 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
0.0 | 0.2 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.0 | 0.3 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.0 | 0.5 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.0 | 0.3 | GO:0016594 | glycine binding(GO:0016594) |
0.0 | 0.1 | GO:0015217 | ADP transmembrane transporter activity(GO:0015217) coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
0.0 | 0.7 | GO:0017091 | AU-rich element binding(GO:0017091) |
0.0 | 0.3 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
0.0 | 0.1 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
0.0 | 0.3 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
0.0 | 0.3 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
0.0 | 0.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
0.0 | 0.1 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
0.0 | 0.6 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.5 | GO:0030552 | cAMP binding(GO:0030552) |
0.0 | 0.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.0 | 0.1 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132) |
0.0 | 0.4 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.0 | 0.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.4 | GO:0043014 | alpha-tubulin binding(GO:0043014) |