Motif ID: Nkx2-4

Z-value: 0.487


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_147085483-0.125.5e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_4611971 1.331 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr12_+_38781093 0.663 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr12_+_38780817 0.647 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr14_-_47418407 0.621 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr7_-_115824699 0.621 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr13_+_108316395 0.595 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr9_-_58159201 0.568 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr10_+_88091070 0.564 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr9_-_58158498 0.473 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr6_+_30568367 0.469 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr3_+_76593550 0.469 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr10_+_128232065 0.410 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
 Timeless




timeless circadian clock 1




chr13_-_66852017 0.388 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr3_+_52268337 0.375 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr13_+_65512678 0.351 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr4_-_136892867 0.338 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr6_+_134929089 0.332 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr15_-_26895049 0.327 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr2_+_169632996 0.318 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr12_-_91746020 0.315 ENSMUST00000166967.1
 Ston2
stonin 2
chr10_+_20347788 0.315 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr8_+_45627946 0.308 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr11_-_102579461 0.306 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr6_+_134929118 0.306 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr19_-_6969746 0.298 ENSMUST00000025912.8
 Plcb3
phospholipase C, beta 3
chr2_+_169633517 0.297 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr9_+_108560422 0.290 ENSMUST00000081111.8
 Impdh2
inosine 5'-phosphate dehydrogenase 2
chr8_+_66860215 0.281 ENSMUST00000118009.1
 Naf1
nuclear assembly factor 1 homolog (S. cerevisiae)
chr15_+_99055164 0.273 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr1_+_97024681 0.271 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr8_+_45627709 0.255 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr2_+_156840966 0.229 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr1_+_178798438 0.210 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr19_-_45742873 0.210 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr8_+_45628176 0.208 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr13_-_105271039 0.188 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr10_+_42502197 0.184 ENSMUST00000105499.1
 Snx3
sorting nexin 3
chr2_+_61804453 0.181 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr2_+_25180737 0.179 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr5_+_89027959 0.173 ENSMUST00000130041.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr8_+_4248188 0.164 ENSMUST00000110993.1
 Gm14378
predicted gene 14378
chr17_+_86753900 0.152 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr5_+_89028035 0.143 ENSMUST00000113216.2
ENSMUST00000134303.1
 Slc4a4

solute carrier family 4 (anion exchanger), member 4

chr3_+_96696379 0.140 ENSMUST00000107076.3
 Pias3
protein inhibitor of activated STAT 3
chr13_+_3478226 0.139 ENSMUST00000181708.1
ENSMUST00000180836.1
ENSMUST00000180567.1
 2810429I04Rik


RIKEN cDNA 2810429I04 gene


chr3_+_121291725 0.136 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr17_-_25844514 0.131 ENSMUST00000176709.1
 Rhot2
ras homolog gene family, member T2
chr7_-_100932140 0.128 ENSMUST00000107032.1
 Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr18_-_3281036 0.119 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
 Crem


cAMP responsive element modulator


chr9_-_71896047 0.106 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr11_+_110968016 0.106 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr14_+_26514554 0.098 ENSMUST00000104927.1
 Gm2178
predicted gene 2178
chr4_+_62525369 0.095 ENSMUST00000062145.1
 4933430I17Rik
RIKEN cDNA 4933430I17 gene
chr17_-_25844417 0.093 ENSMUST00000176591.1
 Rhot2
ras homolog gene family, member T2
chr6_+_123229843 0.084 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
 Clec4n


C-type lectin domain family 4, member n


chr7_-_132813095 0.078 ENSMUST00000106165.1
 Fam53b
family with sequence similarity 53, member B
chrX_+_101383726 0.078 ENSMUST00000119190.1
 Gjb1
gap junction protein, beta 1
chr6_-_29165003 0.078 ENSMUST00000007993.9
 Rbm28
RNA binding motif protein 28
chr2_+_30061754 0.077 ENSMUST00000149578.1
ENSMUST00000102866.3
 Set

SET nuclear oncogene

chr3_-_59220150 0.073 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr12_+_69963452 0.072 ENSMUST00000110560.1
 Gm3086
predicted gene 3086
chr11_+_101733011 0.072 ENSMUST00000129741.1
 Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr7_+_82867327 0.064 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr4_-_40279389 0.057 ENSMUST00000108108.2
ENSMUST00000095128.3
 Ndufb6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6

chr2_+_157456917 0.056 ENSMUST00000109529.1
 Src
Rous sarcoma oncogene
chr8_+_11556061 0.054 ENSMUST00000054399.4
 Ing1
inhibitor of growth family, member 1
chr3_-_110250963 0.051 ENSMUST00000106567.1
 Prmt6
protein arginine N-methyltransferase 6
chr1_+_34439851 0.050 ENSMUST00000027303.7
 Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr11_+_110968056 0.046 ENSMUST00000125692.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr8_-_31739763 0.045 ENSMUST00000178878.1
 Gm5117
predicted gene 5117
chr17_+_16972910 0.042 ENSMUST00000071374.5
 BC002059
cDNA sequence BC002059
chr15_-_100669512 0.035 ENSMUST00000182574.1
ENSMUST00000182775.1
 Bin2

bridging integrator 2

chr8_+_88199194 0.032 ENSMUST00000119033.1
ENSMUST00000066748.3
ENSMUST00000118952.1
 Papd5


PAP associated domain containing 5


chr18_-_3281712 0.030 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
 Crem



cAMP responsive element modulator



chr1_-_63114516 0.030 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr11_+_98863610 0.030 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr17_-_51832666 0.029 ENSMUST00000144331.1
 Satb1
special AT-rich sequence binding protein 1
chr11_+_101732950 0.028 ENSMUST00000039152.7
 Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr15_-_100669496 0.028 ENSMUST00000182814.1
ENSMUST00000182068.1
 Bin2

bridging integrator 2

chr2_-_93046053 0.026 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr1_+_85650008 0.024 ENSMUST00000054279.8
ENSMUST00000147552.1
ENSMUST00000153574.1
ENSMUST00000150967.1
 Sp100



nuclear antigen Sp100



chr19_+_55741810 0.017 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr4_-_108848619 0.017 ENSMUST00000164855.1
 A730015C16Rik
RIKEN cDNA A730015C16 gene
chr6_+_94500313 0.017 ENSMUST00000061118.8
 Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr1_-_34439672 0.017 ENSMUST00000042493.8
 Ccdc115
coiled-coil domain containing 115
chr14_+_48446128 0.011 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr14_+_55672235 0.009 ENSMUST00000002397.5
 Gmpr2
guanosine monophosphate reductase 2
chr8_+_31091593 0.006 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr2_-_27507656 0.003 ENSMUST00000154316.1
 Brd3
bromodomain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 0.6 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.2 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.1 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.2 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.3 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.4 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 1.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.2 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.0 0.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.2 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.1 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.3 GO:1904872 regulation of telomerase RNA localization to Cajal body(GO:1904872) positive regulation of telomerase RNA localization to Cajal body(GO:1904874)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.2 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.1 GO:0033234 negative regulation of protein sumoylation(GO:0033234)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0044299 C-fiber(GO:0044299)
0.1 1.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0032009 early phagosome(GO:0032009)
0.0 0.0 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.3 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.0 GO:0030519 snoRNP binding(GO:0030519)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)