Motif ID: Nkx2-4

Z-value: 0.487


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_147085483-0.125.5e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_4611971 1.331 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr12_+_38781093 0.663 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr12_+_38780817 0.647 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr14_-_47418407 0.621 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr7_-_115824699 0.621 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr13_+_108316395 0.595 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr9_-_58159201 0.568 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr10_+_88091070 0.564 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr9_-_58158498 0.473 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr6_+_30568367 0.469 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr3_+_76593550 0.469 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr10_+_128232065 0.410 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
 Timeless




timeless circadian clock 1




chr13_-_66852017 0.388 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr3_+_52268337 0.375 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr13_+_65512678 0.351 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr4_-_136892867 0.338 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr6_+_134929089 0.332 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr15_-_26895049 0.327 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr2_+_169632996 0.318 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr12_-_91746020 0.315 ENSMUST00000166967.1
 Ston2
stonin 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 1.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 0.6 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.4 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.0 0.4 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.3 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.3 GO:1904872 regulation of telomerase RNA localization to Cajal body(GO:1904872) positive regulation of telomerase RNA localization to Cajal body(GO:1904874)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.2 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.1 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.2 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.0 0.2 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.2 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)

Gene overrepresentation in cellular_component category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.3 GO:0044299 C-fiber(GO:0044299)
0.0 0.3 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.2 GO:0032009 early phagosome(GO:0032009)
0.0 0.0 GO:0034457 Mpp10 complex(GO:0034457)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.0 GO:0030519 snoRNP binding(GO:0030519)