Motif ID: Nkx2-5

Z-value: 0.746


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_31949571 3.622 ENSMUST00000064016.5
Gpr17
G protein-coupled receptor 17
chr15_-_88978958 3.509 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr8_-_46294592 2.039 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr1_+_172341197 1.909 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr3_+_52268337 1.553 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr12_+_74297474 1.425 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr15_-_54919961 1.413 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr12_+_37880700 1.346 ENSMUST00000040500.7
Dgkb
diacylglycerol kinase, beta
chr14_+_80000292 1.332 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr6_-_101377342 1.256 ENSMUST00000151175.1
Pdzrn3
PDZ domain containing RING finger 3
chr15_-_33405976 1.152 ENSMUST00000079057.6
1700084J12Rik
RIKEN cDNA 1700084J12 gene
chr12_+_91400990 1.101 ENSMUST00000021346.7
ENSMUST00000021343.6
Tshr

thyroid stimulating hormone receptor

chr15_-_54920115 1.022 ENSMUST00000171545.1
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr19_+_26753588 0.874 ENSMUST00000177116.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_+_128246812 0.833 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr3_-_95411176 0.803 ENSMUST00000177599.1
Gm5070
predicted gene 5070
chr11_+_4620067 0.740 ENSMUST00000109941.1
Gm11032
predicted gene 11032
chr9_-_53536608 0.727 ENSMUST00000150244.1
Atm
ataxia telangiectasia mutated homolog (human)
chr1_-_66817536 0.714 ENSMUST00000068168.3
ENSMUST00000113987.1
Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr7_+_128246953 0.714 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr5_-_8997324 0.706 ENSMUST00000003720.4
Crot
carnitine O-octanoyltransferase
chr11_-_101987004 0.641 ENSMUST00000107173.2
ENSMUST00000107172.1
Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr15_-_10470490 0.632 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr8_+_124793061 0.620 ENSMUST00000041106.7
Trim67
tripartite motif-containing 67
chr5_+_138085083 0.611 ENSMUST00000019660.4
ENSMUST00000066617.5
ENSMUST00000110963.1
Zkscan1


zinc finger with KRAB and SCAN domains 1


chr5_-_124327883 0.603 ENSMUST00000031344.6
Mphosph9
M-phase phosphoprotein 9
chr5_-_124327812 0.599 ENSMUST00000184951.1
Mphosph9
M-phase phosphoprotein 9
chr18_+_49832622 0.534 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr4_-_87806276 0.533 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr16_+_44173271 0.529 ENSMUST00000088356.4
ENSMUST00000169582.1
Gm608

predicted gene 608

chr16_+_44139821 0.495 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr1_-_163725123 0.494 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr4_+_137594140 0.481 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
Usp48



ubiquitin specific peptidase 48



chr2_+_52038005 0.457 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr13_+_30136529 0.448 ENSMUST00000152798.1
Mboat1
membrane bound O-acyltransferase domain containing 1
chr2_-_5942740 0.443 ENSMUST00000026924.5
ENSMUST00000095147.2
ENSMUST00000169865.1
Dhtkd1


dehydrogenase E1 and transketolase domain containing 1


chr2_+_80315461 0.443 ENSMUST00000028392.7
Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr5_-_106624390 0.428 ENSMUST00000112694.1
Zfp644
zinc finger protein 644
chrX_-_75416533 0.408 ENSMUST00000033542.4
Mtcp1
mature T cell proliferation 1
chr16_-_44139630 0.408 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr17_-_29716969 0.407 ENSMUST00000129091.1
ENSMUST00000128751.1
Ccdc167

coiled-coil domain containing 167

chr14_+_21500879 0.405 ENSMUST00000182964.1
Kat6b
K(lysine) acetyltransferase 6B
chr19_+_16956110 0.373 ENSMUST00000087689.4
Prune2
prune homolog 2 (Drosophila)
chr17_-_55915870 0.372 ENSMUST00000074828.4
Rpl21-ps6
ribosomal protein L21, pseudogene 6
chr2_-_173276144 0.370 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chrX_+_13071500 0.364 ENSMUST00000089302.4
Usp9x
ubiquitin specific peptidase 9, X chromosome
chr6_-_83572429 0.353 ENSMUST00000068054.7
Stambp
STAM binding protein
chr13_+_30136498 0.342 ENSMUST00000047311.8
Mboat1
membrane bound O-acyltransferase domain containing 1
chr2_+_174076296 0.342 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr17_+_88440711 0.341 ENSMUST00000112238.2
ENSMUST00000155640.1
Foxn2

forkhead box N2

chr10_-_42018363 0.338 ENSMUST00000162405.1
ENSMUST00000095729.4
ENSMUST00000161081.1
ENSMUST00000160262.2
Armc2



armadillo repeat containing 2



chr2_+_23069210 0.326 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr1_+_128103297 0.318 ENSMUST00000036288.4
R3hdm1
R3H domain containing 1
chr4_-_87806296 0.316 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr9_+_57940104 0.301 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr7_+_29071597 0.299 ENSMUST00000180926.1
Gm26604
predicted gene, 26604
chr2_+_69897220 0.294 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr4_-_108625216 0.260 ENSMUST00000166069.1
Gm20731
predicted gene, 20731
chr11_-_96916407 0.235 ENSMUST00000130774.1
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr7_+_18991245 0.226 ENSMUST00000130268.1
ENSMUST00000059331.8
ENSMUST00000131087.1
Mypop


Myb-related transcription factor, partner of profilin


chr2_-_73892588 0.219 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
Atf2


activating transcription factor 2


chr16_-_85173692 0.218 ENSMUST00000005406.10
App
amyloid beta (A4) precursor protein
chr3_+_103739366 0.214 ENSMUST00000106852.1
Gm10964
predicted gene 10964
chr2_+_127270208 0.209 ENSMUST00000110375.2
Stard7
START domain containing 7
chr16_+_44943737 0.206 ENSMUST00000114622.3
ENSMUST00000166731.1
Cd200r3

CD200 receptor 3

chr4_-_126968124 0.197 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr2_-_73892619 0.195 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2

activating transcription factor 2

chr2_-_73892530 0.192 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2



activating transcription factor 2



chrX_-_75416562 0.176 ENSMUST00000114081.1
ENSMUST00000033543.7
ENSMUST00000149863.2
Mtcp1
Mtcp1

mature T cell proliferation 1
mature T cell proliferation 1

chr19_+_8819401 0.175 ENSMUST00000096753.3
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr18_-_79109391 0.171 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1

SET binding protein 1

chrX_+_114474312 0.161 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4

kelch-like 4

chr4_+_103619580 0.157 ENSMUST00000106827.1
Dab1
disabled 1
chr19_-_57360668 0.150 ENSMUST00000181921.1
B230217O12Rik
RIKEN cDNA B230217O12 gene
chr1_-_86359455 0.147 ENSMUST00000027438.6
Ncl
nucleolin
chr15_-_99457712 0.144 ENSMUST00000161948.1
Nckap5l
NCK-associated protein 5-like
chr3_-_89160155 0.135 ENSMUST00000029686.3
Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr15_-_82224330 0.125 ENSMUST00000089161.2
ENSMUST00000109535.2
Tnfrsf13c

tumor necrosis factor receptor superfamily, member 13c

chr8_+_113643206 0.123 ENSMUST00000034219.4
ENSMUST00000095173.1
Syce1l

synaptonemal complex central element protein 1 like

chr4_-_45532470 0.119 ENSMUST00000147448.1
Shb
src homology 2 domain-containing transforming protein B
chr11_-_3976778 0.119 ENSMUST00000042344.1
4930556J24Rik
RIKEN cDNA 4930556J24 gene
chr14_+_20674311 0.114 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr17_+_35379608 0.107 ENSMUST00000081435.4
H2-Q4
histocompatibility 2, Q region locus 4
chr2_-_120609500 0.102 ENSMUST00000133612.1
ENSMUST00000102498.1
ENSMUST00000102499.1
Lrrc57


leucine rich repeat containing 57


chr6_+_115853470 0.099 ENSMUST00000112925.1
ENSMUST00000112923.1
ENSMUST00000038234.6
Ift122


intraflagellar transport 122


chr5_-_5265224 0.085 ENSMUST00000115450.1
Cdk14
cyclin-dependent kinase 14
chrX_-_111463103 0.078 ENSMUST00000137712.2
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chrX_-_111463149 0.067 ENSMUST00000096348.3
ENSMUST00000113428.2
Rps6ka6

ribosomal protein S6 kinase polypeptide 6

chrX_-_64276937 0.065 ENSMUST00000114679.1
ENSMUST00000069926.7
Slitrk4

SLIT and NTRK-like family, member 4

chr2_+_120609383 0.062 ENSMUST00000124187.1
Haus2
HAUS augmin-like complex, subunit 2
chr2_+_32288317 0.061 ENSMUST00000131712.1
ENSMUST00000133113.1
ENSMUST00000081670.6
ENSMUST00000147707.1
ENSMUST00000129193.1
Golga2




golgi autoantigen, golgin subfamily a, 2




chr7_+_100607660 0.058 ENSMUST00000098252.4
Rab6a
RAB6A, member RAS oncogene family
chr11_-_96916366 0.057 ENSMUST00000144731.1
ENSMUST00000127048.1
Cdk5rap3

CDK5 regulatory subunit associated protein 3

chr14_+_51893610 0.042 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr4_+_62619515 0.036 ENSMUST00000084521.4
ENSMUST00000107424.1
Rgs3

regulator of G-protein signaling 3

chr15_-_99457742 0.030 ENSMUST00000023747.7
Nckap5l
NCK-associated protein 5-like
chr9_+_54917252 0.029 ENSMUST00000039742.7
Hykk
hydroxylysine kinase 1
chr2_-_120609283 0.028 ENSMUST00000102496.1
Lrrc57
leucine rich repeat containing 57
chr6_-_115853346 0.026 ENSMUST00000032469.6
Mbd4
methyl-CpG binding domain protein 4
chr12_+_4082596 0.023 ENSMUST00000049584.5
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chrX_-_111463043 0.021 ENSMUST00000065976.5
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr8_-_95113334 0.016 ENSMUST00000169353.1
Kifc3
kinesin family member C3
chr9_+_106170918 0.008 ENSMUST00000020490.5
Wdr82
WD repeat domain containing 82

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.5 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.6 1.9 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.4 3.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.3 2.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 0.7 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.2 1.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 0.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.2 1.6 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 2.0 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.8 GO:0007379 segment specification(GO:0007379)
0.1 0.4 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 1.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 0.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.2 GO:0071873 response to norepinephrine(GO:0071873)
0.1 0.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 0.7 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.1 0.3 GO:0030242 pexophagy(GO:0030242)
0.1 0.2 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.0 0.6 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.0 0.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 1.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.3 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.6 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 0.1 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324) meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764)
0.0 0.4 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.4 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0001651 dense fibrillar component(GO:0001651)
0.0 3.5 GO:0005901 caveola(GO:0005901)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.7 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.6 2.4 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.2 1.5 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.4 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.1 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 2.0 GO:0016414 O-octanoyltransferase activity(GO:0016414)
0.1 0.4 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.7 GO:0004677 DNA-dependent protein kinase activity(GO:0004677) 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.4 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 3.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.3 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.6 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 2.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)