Motif ID: Nkx2-5

Z-value: 0.746


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Showing 1 to 20 of 103 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_31949571 3.622 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr15_-_88978958 3.509 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr8_-_46294592 2.039 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr1_+_172341197 1.909 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr3_+_52268337 1.553 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr12_+_74297474 1.425 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr15_-_54919961 1.413 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr12_+_37880700 1.346 ENSMUST00000040500.7
 Dgkb
diacylglycerol kinase, beta
chr14_+_80000292 1.332 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr6_-_101377342 1.256 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr15_-_33405976 1.152 ENSMUST00000079057.6
 1700084J12Rik
RIKEN cDNA 1700084J12 gene
chr12_+_91400990 1.101 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr15_-_54920115 1.022 ENSMUST00000171545.1
 Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr19_+_26753588 0.874 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_+_128246812 0.833 ENSMUST00000164710.1
ENSMUST00000070656.5
 Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr3_-_95411176 0.803 ENSMUST00000177599.1
 Gm5070
predicted gene 5070
chr11_+_4620067 0.740 ENSMUST00000109941.1
 Gm11032
predicted gene 11032
chr9_-_53536608 0.727 ENSMUST00000150244.1
 Atm
ataxia telangiectasia mutated homolog (human)
chr1_-_66817536 0.714 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr7_+_128246953 0.714 ENSMUST00000167965.1
 Tgfb1i1
transforming growth factor beta 1 induced transcript 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.7 3.5 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.3 2.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 2.0 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.6 1.9 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.2 1.6 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.2 1.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 0.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.8 GO:0007379 segment specification(GO:0007379)
0.0 0.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.2 0.7 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.7 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.2 0.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.6 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.6 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 0.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0005901 caveola(GO:0005901)
0.2 2.1 GO:0097449 astrocyte projection(GO:0097449)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.7 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0001651 dense fibrillar component(GO:0001651)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0008565 protein transporter activity(GO:0008565)
0.6 2.4 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 2.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 2.0 GO:0016414 O-octanoyltransferase activity(GO:0016414)
0.0 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 1.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 1.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 1.5 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.3 GO:0045296 cadherin binding(GO:0045296)
0.1 1.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.7 GO:0004677 DNA-dependent protein kinase activity(GO:0004677) 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.1 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.6 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.4 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.1 0.4 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.4 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 0.4 GO:0070410 co-SMAD binding(GO:0070410)