Motif ID: Nkx2-5
Z-value: 0.746
Transcription factors associated with Nkx2-5:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx2-5 | ENSMUSG00000015579.4 | Nkx2-5 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 3.5 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
0.6 | 1.9 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
0.4 | 3.6 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
0.3 | 2.4 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
0.2 | 0.7 | GO:0002331 | pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
0.2 | 1.5 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
0.2 | 0.6 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
0.2 | 1.6 | GO:0071732 | cellular response to nitric oxide(GO:0071732) |
0.1 | 2.0 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
0.1 | 0.4 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
0.1 | 0.9 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
0.1 | 0.8 | GO:0007379 | segment specification(GO:0007379) |
0.1 | 0.4 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
0.1 | 1.1 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
0.1 | 0.4 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
0.1 | 0.3 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
0.1 | 0.2 | GO:0071873 | response to norepinephrine(GO:0071873) |
0.1 | 0.5 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
0.1 | 0.7 | GO:0051791 | medium-chain fatty acid metabolic process(GO:0051791) |
0.1 | 0.3 | GO:0030242 | pexophagy(GO:0030242) |
0.1 | 0.2 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
0.1 | 1.3 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
0.0 | 0.1 | GO:0002636 | positive regulation of germinal center formation(GO:0002636) |
0.0 | 0.6 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
0.0 | 0.1 | GO:0090069 | regulation of ribosome biogenesis(GO:0090069) |
0.0 | 0.3 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
0.0 | 1.3 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.0 | 0.3 | GO:0071569 | protein ufmylation(GO:0071569) |
0.0 | 0.6 | GO:2000060 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060) |
0.0 | 0.1 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) embryonic heart tube left/right pattern formation(GO:0060971) |
0.0 | 0.4 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
0.0 | 0.1 | GO:0007128 | meiotic prophase I(GO:0007128) prophase(GO:0051324) meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764) |
0.0 | 0.4 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
0.0 | 0.1 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.0 | 0.8 | GO:0007528 | neuromuscular junction development(GO:0007528) |
0.0 | 0.4 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
0.0 | 0.2 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
0.0 | 0.4 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
0.0 | 0.1 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.1 | GO:0097449 | astrocyte projection(GO:0097449) |
0.1 | 0.5 | GO:0031415 | NatA complex(GO:0031415) |
0.0 | 0.9 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.4 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.0 | 0.4 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
0.0 | 0.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 0.4 | GO:0042581 | specific granule(GO:0042581) |
0.0 | 0.1 | GO:0001651 | dense fibrillar component(GO:0001651) |
0.0 | 3.5 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.1 | GO:0044316 | cone cell pedicle(GO:0044316) |
0.0 | 0.6 | GO:0001772 | immunological synapse(GO:0001772) |
0.0 | 0.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 0.6 | GO:0035861 | site of double-strand break(GO:0035861) |
0.0 | 0.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.0 | 1.3 | GO:0031594 | neuromuscular junction(GO:0031594) |
0.0 | 0.7 | GO:1990391 | DNA repair complex(GO:1990391) |
0.0 | 1.2 | GO:0005814 | centriole(GO:0005814) |
0.0 | 0.1 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 1.9 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
0.6 | 2.4 | GO:0004528 | phosphodiesterase I activity(GO:0004528) |
0.2 | 1.5 | GO:0048495 | Roundabout binding(GO:0048495) |
0.1 | 1.3 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
0.1 | 1.6 | GO:0001223 | transcription coactivator binding(GO:0001223) |
0.1 | 1.1 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.1 | 0.4 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
0.1 | 0.6 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.1 | 2.0 | GO:0016414 | O-octanoyltransferase activity(GO:0016414) |
0.1 | 0.4 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
0.0 | 0.7 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
0.0 | 0.2 | GO:0051425 | PTB domain binding(GO:0051425) |
0.0 | 0.4 | GO:0016920 | pyroglutamyl-peptidase activity(GO:0016920) |
0.0 | 3.5 | GO:0008565 | protein transporter activity(GO:0008565) |
0.0 | 1.3 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 0.3 | GO:0038191 | neuropilin binding(GO:0038191) |
0.0 | 0.1 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
0.0 | 0.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 0.1 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
0.0 | 0.3 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
0.0 | 0.6 | GO:0033549 | MAP kinase phosphatase activity(GO:0033549) |
0.0 | 0.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.0 | 0.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.0 | 0.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.4 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
0.0 | 2.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.1 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
0.0 | 2.2 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |