Motif ID: Nkx2-6

Z-value: 0.249


Transcription factors associated with Nkx2-6:

Gene SymbolEntrez IDGene Name
Nkx2-6 ENSMUSG00000044186.9 Nkx2-6



Activity profile for motif Nkx2-6.

activity profile for motif Nkx2-6


Sorted Z-values histogram for motif Nkx2-6

Sorted Z-values for motif Nkx2-6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116237767 1.003 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr7_-_116031047 0.714 ENSMUST00000106612.1
 Sox6
SRY-box containing gene 6
chr5_+_110330697 0.526 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr2_-_147186389 0.469 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr10_+_100488289 0.361 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr15_-_78773452 0.361 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_+_156035392 0.331 ENSMUST00000111757.3
 Tor1aip2
torsin A interacting protein 2
chr4_-_91399984 0.254 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr3_+_87525572 0.244 ENSMUST00000170036.1
ENSMUST00000117293.1
 Etv3

ets variant gene 3

chr1_-_156034826 0.227 ENSMUST00000141878.1
ENSMUST00000123705.1
 Tor1aip1

torsin A interacting protein 1

chr1_-_156034800 0.201 ENSMUST00000169241.1
 Tor1aip1
torsin A interacting protein 1
chr4_-_109665249 0.196 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr2_+_23069210 0.180 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr2_+_3114220 0.128 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr9_-_10904766 0.093 ENSMUST00000160216.1
 Cntn5
contactin 5
chr2_-_121456693 0.087 ENSMUST00000110613.2
ENSMUST00000056312.3
 Serinc4

serine incorporator 4

chr11_+_103774150 0.085 ENSMUST00000000127.5
 Wnt3
wingless-related MMTV integration site 3
chr4_+_62619515 0.062 ENSMUST00000084521.4
ENSMUST00000107424.1
 Rgs3

regulator of G-protein signaling 3

chr9_-_10904697 0.053 ENSMUST00000162484.1
 Cntn5
contactin 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 0.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.5 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 0.7 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.4 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.3 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.2 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.0 0.4 GO:0045494 photoreceptor cell maintenance(GO:0045494)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.8 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)