Motif ID: Nkx2-9
Z-value: 0.764
Transcription factors associated with Nkx2-9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-9 | ENSMUSG00000058669.7 | Nkx2-9 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-9 | mm10_v2_chr12_-_56613270_56613291 | 0.82 | 3.0e-07 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.8 | 2.3 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 0.5 | 3.7 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.5 | 1.4 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.5 | 1.4 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.4 | 1.2 | GO:0021557 | oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
| 0.4 | 1.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.4 | 1.5 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.3 | 1.1 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.3 | 0.8 | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response(GO:1903896) |
| 0.3 | 1.0 | GO:0002339 | B cell selection(GO:0002339) |
| 0.2 | 0.7 | GO:2000054 | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054) |
| 0.2 | 0.5 | GO:1902071 | regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
| 0.2 | 1.9 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.2 | 1.0 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.1 | 1.3 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 0.8 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
| 0.1 | 1.8 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
| 0.1 | 0.6 | GO:2000065 | negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065) |
| 0.1 | 0.8 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
| 0.1 | 1.3 | GO:0097067 | negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.1 | 1.1 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.1 | 0.8 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.1 | 0.2 | GO:0034310 | primary alcohol catabolic process(GO:0034310) |
| 0.1 | 0.7 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.2 | GO:1903225 | regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.4 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.1 | 0.3 | GO:2000587 | regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.0 | 0.2 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.0 | 0.3 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
| 0.0 | 0.5 | GO:0000059 | protein import into nucleus, docking(GO:0000059) |
| 0.0 | 0.8 | GO:0055070 | copper ion homeostasis(GO:0055070) |
| 0.0 | 1.3 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.2 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.1 | GO:0042790 | transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790) |
| 0.0 | 0.1 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
| 0.0 | 0.2 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.0 | 1.1 | GO:0048536 | spleen development(GO:0048536) |
| 0.0 | 1.4 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.0 | 0.8 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.2 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.0 | 0.8 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 1.0 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.8 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 0.6 | GO:0007588 | excretion(GO:0007588) |
| 0.0 | 0.1 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.0 | 0.4 | GO:0042088 | T-helper 1 type immune response(GO:0042088) |
| 0.0 | 0.2 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.4 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.7 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 0.1 | 1.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 1.5 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.1 | 0.5 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.1 | 0.4 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.1 | 1.1 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 1.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 0.1 | GO:0031251 | PAN complex(GO:0031251) |
| 0.0 | 0.5 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.0 | 1.4 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 0.2 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.7 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.1 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.0 | 1.4 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.0 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.2 | GO:0001527 | microfibril(GO:0001527) |
| 0.0 | 7.0 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.7 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.4 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.2 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.0 | 0.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.3 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 1.0 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.6 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.3 | 3.8 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.2 | 0.8 | GO:0003844 | 1,4-alpha-glucan branching enzyme activity(GO:0003844) |
| 0.2 | 1.4 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.2 | 1.1 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
| 0.1 | 0.4 | GO:0048019 | receptor antagonist activity(GO:0048019) |
| 0.1 | 1.4 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.1 | 2.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 1.0 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 0.4 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.1 | 0.8 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 3.7 | GO:0043027 | Ran GTPase binding(GO:0008536) cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 1.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 0.3 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.1 | 1.5 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 1.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 0.8 | GO:0070636 | single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694) |
| 0.1 | 1.1 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 0.6 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 2.6 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 0.6 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.1 | 0.9 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 0.5 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 0.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.7 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 0.8 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 0.4 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 1.0 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.6 | GO:0070402 | NADPH binding(GO:0070402) |
| 0.0 | 0.3 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 1.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.1 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.0 | 0.2 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.0 | 0.2 | GO:0016653 | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653) |
| 0.0 | 0.1 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
| 0.0 | 0.8 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 1.1 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.2 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.8 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
| 0.0 | 11.2 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 1.3 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
