Motif ID: Nkx2-9

Z-value: 0.764


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_566132910.823.0e-07Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_71963713 5.526 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr13_+_72632597 3.943 ENSMUST00000172353.1
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr12_-_56536895 3.812 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr10_+_88091070 2.255 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr11_+_117849223 1.997 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr2_+_173022360 1.932 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr8_+_95633500 1.888 ENSMUST00000034094.9
 Gins3
GINS complex subunit 3 (Psf3 homolog)
chr8_-_46294592 1.828 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr11_+_117849286 1.744 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr16_-_59555752 1.719 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr16_-_33380717 1.711 ENSMUST00000180923.1
 1700007L15Rik
RIKEN cDNA 1700007L15 gene
chr6_-_6217023 1.557 ENSMUST00000015256.8
 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr7_+_4925802 1.547 ENSMUST00000057612.7
 Ssc5d
scavenger receptor cysteine rich domain containing (5 domains)
chr4_+_8690399 1.429 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr1_-_128103016 1.406 ENSMUST00000097597.2
 Zranb3
zinc finger, RAN-binding domain containing 3
chr1_-_181842334 1.400 ENSMUST00000005003.6
 Lbr
lamin B receptor
chr2_+_103969528 1.327 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr3_+_122419772 1.296 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr16_+_30065333 1.244 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr11_+_88718442 1.203 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 3.8 GO:0021759 globus pallidus development(GO:0021759)
0.5 3.7 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.8 2.3 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 1.9 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 1.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.4 1.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.4 1.5 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.5 1.4 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.5 1.4 GO:0036292 DNA rewinding(GO:0036292)
0.0 1.4 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 1.3 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 1.3 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.0 1.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.4 1.2 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.3 1.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.1 GO:0060539 diaphragm development(GO:0060539)
0.0 1.1 GO:0048536 spleen development(GO:0048536)
0.3 1.0 GO:0002339 B cell selection(GO:0002339)
0.2 1.0 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 1.0 GO:0045454 cell redox homeostasis(GO:0045454)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)
1.2 3.7 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 1.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.4 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.4 GO:0005844 polysome(GO:0005844)
0.0 1.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.3 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 1.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.3 3.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 3.7 GO:0043027 Ran GTPase binding(GO:0008536) cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.6 GO:0070888 E-box binding(GO:0070888)
0.1 2.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.4 1.6 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 1.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 1.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 1.4 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 1.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 1.1 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.1 1.1 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.0 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)