Motif ID: Nkx3-2

Z-value: 0.660


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66969616 3.138 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr5_-_139130159 2.593 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr9_+_57940104 2.120 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr12_-_72408934 1.824 ENSMUST00000078505.7
 Rtn1
reticulon 1
chr10_-_86732409 1.792 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr11_+_3332426 1.734 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr9_-_21037775 1.692 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr6_-_136171722 1.685 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr11_-_72489904 1.602 ENSMUST00000045303.3
 Spns2
spinster homolog 2
chr2_-_104409992 1.576 ENSMUST00000149466.1
ENSMUST00000139015.1
 D430041D05Rik

RIKEN cDNA D430041D05 gene

chr2_+_25054396 1.563 ENSMUST00000102931.4
ENSMUST00000074422.7
ENSMUST00000132172.1
ENSMUST00000114388.1
ENSMUST00000114386.1
 Nsmf




NMDA receptor synaptonuclear signaling and neuronal migration factor




chr4_-_120747248 1.551 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr9_+_112234257 1.423 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr9_-_58313189 1.413 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr17_+_70561739 1.407 ENSMUST00000097288.2
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr10_+_38965515 1.340 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr11_-_35798884 1.302 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr4_+_102421518 1.289 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_156992021 1.264 ENSMUST00000109558.1
ENSMUST00000069600.6
ENSMUST00000072298.6
 Ndrg3


N-myc downstream regulated gene 3


chr11_+_43474276 1.242 ENSMUST00000173002.1
ENSMUST00000057679.3
 C1qtnf2

C1q and tumor necrosis factor related protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.1 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 3.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 2.8 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 2.2 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.2 2.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 2.1 GO:2000821 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of grooming behavior(GO:2000821)
0.0 2.0 GO:0098792 xenophagy(GO:0098792)
0.3 1.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.4 1.6 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.3 1.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.1 1.5 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 1.5 GO:0033622 integrin activation(GO:0033622)
0.0 1.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.3 1.3 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.1 1.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 1.2 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.2 1.2 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.0 1.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 4.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 3.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.8 GO:0097440 apical dendrite(GO:0097440)
0.0 2.7 GO:0005581 collagen trimer(GO:0005581)
0.0 2.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 1.7 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.4 GO:0000421 autophagosome membrane(GO:0000421)
0.2 1.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.3 GO:0005605 basal lamina(GO:0005605)
0.1 1.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.3 GO:0005604 basement membrane(GO:0005604)
0.3 1.2 GO:0032280 symmetric synapse(GO:0032280)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.0 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 3.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 2.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 2.4 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.3 2.1 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 2.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.8 GO:0005178 integrin binding(GO:0005178)
0.6 1.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.3 1.6 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.5 1.4 GO:0043912 D-lysine oxidase activity(GO:0043912)
0.2 1.2 GO:0001515 opioid peptide activity(GO:0001515)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 1.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.3 1.0 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 1.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 1.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 0.9 GO:0003872 6-phosphofructokinase activity(GO:0003872)