Motif ID: Nkx6-1_Evx1_Hesx1

Z-value: 0.706

Transcription factors associated with Nkx6-1_Evx1_Hesx1:

Gene SymbolEntrez IDGene Name
Evx1 ENSMUSG00000005503.8 Evx1
Hesx1 ENSMUSG00000040726.8 Hesx1
Nkx6-1 ENSMUSG00000035187.8 Nkx6-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-1mm10_v2_chr5_-_101665195_101665226-0.582.0e-03Click!


Activity profile for motif Nkx6-1_Evx1_Hesx1.

activity profile for motif Nkx6-1_Evx1_Hesx1


Sorted Z-values histogram for motif Nkx6-1_Evx1_Hesx1

Sorted Z-values for motif Nkx6-1_Evx1_Hesx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-1_Evx1_Hesx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_118052235 4.884 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr5_-_62766153 3.587 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_84417359 3.348 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr15_+_18818895 3.297 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr2_+_20737306 2.843 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr11_-_98053415 2.612 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr16_+_45094036 2.395 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr2_+_116067213 2.236 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr15_-_8710734 2.139 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 2.113 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr8_-_109251698 2.111 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr17_+_3397189 1.993 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr15_-_66812593 1.540 ENSMUST00000100572.3
 Sla
src-like adaptor
chr3_+_62419668 1.497 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr2_-_79456750 1.343 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr2_-_5676046 1.272 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr16_-_97170707 1.272 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr9_+_118478182 1.259 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chrX_-_143933204 1.247 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr9_+_118478344 1.244 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.9 GO:0006570 tyrosine metabolic process(GO:0006570)
1.1 4.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 4.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 3.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 3.1 GO:0060074 synapse maturation(GO:0060074)
0.8 2.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 2.4 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 2.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.4 2.3 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 2.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.6 1.8 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 1.7 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 1.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 1.5 GO:0019532 oxalate transport(GO:0019532)
0.1 1.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.4 GO:0007050 cell cycle arrest(GO:0007050)
0.4 1.3 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.3 1.3 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.2 1.3 GO:0060267 positive regulation of respiratory burst(GO:0060267)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 4.3 GO:0043205 fibril(GO:0043205)
0.0 3.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 3.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.9 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.6 GO:0072562 blood microparticle(GO:0072562)
0.1 1.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.3 GO:0030673 axolemma(GO:0030673)
0.0 1.3 GO:0031672 A band(GO:0031672)
0.0 1.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4 1.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 1.1 GO:0060187 cell pole(GO:0060187)
0.1 1.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 1.1 GO:0042641 actomyosin(GO:0042641)
0.1 1.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 0.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 4.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.9 4.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 4.2 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 3.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 3.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.6 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 1.6 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 1.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.4 1.2 GO:0098809 nitrite reductase activity(GO:0098809)
0.3 1.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 1.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.1 GO:0051010 microtubule plus-end binding(GO:0051010)