Motif ID: Nkx6-2

Z-value: 0.981


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.423.1e-02Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 130 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_97584612 3.108 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584605 2.967 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr6_-_144209471 2.487 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 2.395 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr16_+_96467606 2.072 ENSMUST00000061739.8
 Pcp4
Purkinje cell protein 4
chr2_+_62664279 2.065 ENSMUST00000028257.2
 Gca
grancalcin
chr17_-_48432723 1.850 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr6_-_144209448 1.774 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr18_-_42899294 1.638 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr18_+_57142782 1.565 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr10_+_37139558 1.492 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr1_+_194619815 1.372 ENSMUST00000027952.5
 Plxna2
plexin A2
chr18_-_74207771 1.325 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr1_+_184034381 1.265 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr1_-_126830632 1.104 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr8_-_61902669 1.055 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr19_+_58728887 0.972 ENSMUST00000048644.5
 Pnliprp1
pancreatic lipase related protein 1
chr17_+_82539258 0.954 ENSMUST00000097278.3
 Gm6594
predicted pseudogene 6594
chr12_+_117843873 0.952 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr5_-_51553896 0.934 ENSMUST00000132734.1
 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 6.7 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 2.1 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.1 1.8 GO:0080111 DNA demethylation(GO:0080111)
0.3 1.6 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.2 1.6 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.0 1.6 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 1.4 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 1.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.3 1.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268)
0.1 1.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 0.9 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.2 0.9 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.2 0.7 GO:1903463 mitotic cell cycle phase(GO:0098763) regulation of mitotic cell cycle DNA replication(GO:1903463)
0.1 0.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.6 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.6 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.6 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 0.5 GO:0060023 soft palate development(GO:0060023)
0.0 0.5 GO:0007252 I-kappaB phosphorylation(GO:0007252)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 2.6 GO:0043296 apical junction complex(GO:0043296)
0.2 2.1 GO:0005883 neurofilament(GO:0005883)
0.1 1.6 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.1 GO:0002102 podosome(GO:0002102)
0.1 0.9 GO:0005915 zonula adherens(GO:0005915)
0.0 0.9 GO:0005719 nuclear euchromatin(GO:0005719) apical dendrite(GO:0097440)
0.1 0.7 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.6 GO:0035371 microtubule plus-end(GO:0035371)
0.2 0.5 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0098536 deuterosome(GO:0098536)
0.0 0.4 GO:0051286 cell tip(GO:0051286)
0.0 0.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.4 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 2.3 GO:0005516 calmodulin binding(GO:0005516)
0.1 2.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.8 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 1.6 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 1.6 GO:0051015 actin filament binding(GO:0051015)
0.1 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.9 GO:0045296 cadherin binding(GO:0045296)
0.0 0.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.2 0.6 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.2 0.5 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0016504 peptidase activator activity(GO:0016504)