Motif ID: Nkx6-2
Z-value: 0.981
Transcription factors associated with Nkx6-2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx6-2 | ENSMUSG00000041309.11 | Nkx6-2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx6-2 | mm10_v2_chr7_-_139582790_139582808 | -0.42 | 3.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.7 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.3 | 1.3 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268) |
| 0.3 | 1.6 | GO:0014719 | skeletal muscle satellite cell activation(GO:0014719) |
| 0.3 | 0.9 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.2 | 1.6 | GO:0034047 | regulation of protein phosphatase type 2A activity(GO:0034047) |
| 0.2 | 2.1 | GO:0033603 | positive regulation of dopamine secretion(GO:0033603) |
| 0.2 | 0.9 | GO:0060690 | epithelial cell differentiation involved in salivary gland development(GO:0060690) |
| 0.2 | 0.7 | GO:1903463 | mitotic cell cycle phase(GO:0098763) regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.2 | 0.5 | GO:0060023 | soft palate development(GO:0060023) |
| 0.1 | 1.4 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
| 0.1 | 0.6 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 0.7 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.1 | 0.4 | GO:0072356 | chromosome passenger complex localization to kinetochore(GO:0072356) |
| 0.1 | 1.8 | GO:0080111 | DNA demethylation(GO:0080111) |
| 0.1 | 0.6 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 0.4 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 0.4 | GO:1902965 | protein localization to early endosome(GO:1902946) regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
| 0.1 | 1.1 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 0.4 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.0 | 0.4 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.0 | 0.4 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.0 | 0.4 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.1 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.0 | 0.2 | GO:1903887 | motile primary cilium assembly(GO:1903887) |
| 0.0 | 0.4 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.0 | 0.6 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.5 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.0 | 0.5 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.0 | 0.1 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
| 0.0 | 1.6 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.0 | 0.4 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.0 | 0.2 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.0 | 0.1 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.0 | 0.1 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.0 | 0.1 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.0 | 1.4 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.0 | 0.1 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.0 | 1.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0005883 | neurofilament(GO:0005883) |
| 0.2 | 0.5 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.1 | 1.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 1.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.9 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 1.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 1.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 1.1 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.4 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 6.7 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 0.4 | GO:0051286 | cell tip(GO:0051286) |
| 0.0 | 0.4 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.0 | 0.5 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.4 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.0 | 0.9 | GO:0005719 | nuclear euchromatin(GO:0005719) apical dendrite(GO:0097440) |
| 0.0 | 0.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 2.6 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 0.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.4 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.0 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 0.4 | GO:0000786 | nucleosome(GO:0000786) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
| 0.2 | 0.5 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.1 | 1.6 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
| 0.1 | 2.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 1.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 1.0 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 1.5 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 0.9 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 1.8 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 0.1 | 0.9 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.1 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.0 | 1.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.1 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.0 | 0.7 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.1 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.0 | 0.0 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 2.3 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.4 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 1.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.4 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 6.7 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 0.1 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
