Motif ID: Nkx6-3_Dbx2_Barx2

Z-value: 0.437

Transcription factors associated with Nkx6-3_Dbx2_Barx2:

Gene SymbolEntrez IDGene Name
Barx2 ENSMUSG00000032033.10 Barx2
Dbx2 ENSMUSG00000045608.6 Dbx2
Nkx6-3 ENSMUSG00000063672.6 Nkx6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dbx2mm10_v2_chr15_-_95655960_956559600.009.8e-01Click!


Activity profile for motif Nkx6-3_Dbx2_Barx2.

activity profile for motif Nkx6-3_Dbx2_Barx2


Sorted Z-values histogram for motif Nkx6-3_Dbx2_Barx2

Sorted Z-values for motif Nkx6-3_Dbx2_Barx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-3_Dbx2_Barx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 135 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 2.537 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 1.563 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_+_102589687 1.385 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr14_+_80000292 1.287 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chrX_+_170009892 1.100 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr17_-_81649607 1.048 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr10_-_110000219 1.027 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr5_-_118244861 0.987 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr16_+_11406618 0.972 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr4_-_14621669 0.964 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chrX_-_143933204 0.949 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 0.910 ENSMUST00000087313.3
 Dcx
doublecortin
chr13_+_94083490 0.861 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr5_+_144100387 0.780 ENSMUST00000041804.7
 Lmtk2
lemur tyrosine kinase 2
chr5_-_70842617 0.770 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr13_+_83732438 0.743 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr5_-_62766153 0.711 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_36230426 0.685 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr5_+_29195983 0.636 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
 Rnf32




ring finger protein 32




chr6_-_137169710 0.613 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.1 GO:0019532 oxalate transport(GO:0019532)
0.1 1.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 1.8 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 1.0 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 0.8 GO:1901642 purine nucleoside transmembrane transport(GO:0015860) purine-containing compound transmembrane transport(GO:0072530) nucleoside transmembrane transport(GO:1901642)
0.2 0.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 0.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.8 GO:0033572 transferrin transport(GO:0033572)
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 0.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.6 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.5 GO:0032570 response to progesterone(GO:0032570)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)
0.0 0.5 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.5 GO:0007608 sensory perception of smell(GO:0007608)
0.1 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.4 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 0.3 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.3 GO:0042581 specific granule(GO:0042581)
0.1 1.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.8 GO:0043205 fibril(GO:0043205)
0.0 0.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.1 0.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.7 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 1.2 GO:0045296 cadherin binding(GO:0045296)
0.3 1.0 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 1.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.3 0.8 GO:0015217 ADP transmembrane transporter activity(GO:0015217) coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2 0.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 0.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.4 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)