Motif ID: Nr1h2
Z-value: 1.039
Transcription factors associated with Nr1h2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nr1h2 | ENSMUSG00000060601.6 | Nr1h2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nr1h2 | mm10_v2_chr7_-_44553901_44553955 | 0.81 | 5.6e-07 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 6.5 | GO:0055099 | regulation of Cdc42 protein signal transduction(GO:0032489) response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155) |
0.7 | 2.2 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
0.6 | 3.3 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
0.5 | 2.2 | GO:0044268 | multicellular organismal protein metabolic process(GO:0044268) |
0.5 | 2.6 | GO:0006689 | ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313) |
0.5 | 2.8 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
0.4 | 0.9 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
0.4 | 1.2 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
0.4 | 1.8 | GO:0010730 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
0.3 | 4.9 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
0.3 | 4.5 | GO:0072010 | renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
0.2 | 6.3 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
0.2 | 2.3 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
0.2 | 0.6 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
0.2 | 1.6 | GO:0001922 | B-1 B cell homeostasis(GO:0001922) |
0.2 | 1.3 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.2 | 2.9 | GO:0002115 | store-operated calcium entry(GO:0002115) |
0.2 | 0.9 | GO:0046208 | spermine catabolic process(GO:0046208) |
0.2 | 1.0 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.2 | 2.1 | GO:0007141 | male meiosis I(GO:0007141) |
0.2 | 1.0 | GO:0010528 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) |
0.2 | 0.5 | GO:1902219 | maintenance of blood-brain barrier(GO:0035633) regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
0.1 | 0.9 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
0.1 | 2.8 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.1 | 0.3 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
0.1 | 0.2 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
0.1 | 1.1 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
0.1 | 0.8 | GO:0043206 | extracellular fibril organization(GO:0043206) |
0.1 | 0.6 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
0.1 | 1.5 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
0.1 | 0.2 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) |
0.1 | 0.2 | GO:0014891 | striated muscle atrophy(GO:0014891) |
0.1 | 0.2 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
0.1 | 0.7 | GO:0043117 | positive regulation of vascular permeability(GO:0043117) |
0.1 | 0.3 | GO:0051189 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189) |
0.1 | 3.9 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
0.0 | 0.3 | GO:0006265 | DNA topological change(GO:0006265) |
0.0 | 0.4 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
0.0 | 0.4 | GO:0040016 | embryonic cleavage(GO:0040016) |
0.0 | 0.3 | GO:0006013 | mannose metabolic process(GO:0006013) |
0.0 | 0.3 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
0.0 | 1.5 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
0.0 | 0.6 | GO:0045793 | positive regulation of cell size(GO:0045793) |
0.0 | 1.5 | GO:1901998 | toxin transport(GO:1901998) |
0.0 | 0.4 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) |
0.0 | 0.8 | GO:1901381 | positive regulation of potassium ion transmembrane transport(GO:1901381) |
0.0 | 0.3 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
0.0 | 1.1 | GO:0051865 | protein autoubiquitination(GO:0051865) |
0.0 | 0.3 | GO:0030575 | nuclear body organization(GO:0030575) |
0.0 | 0.2 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.3 | GO:0008091 | spectrin(GO:0008091) |
0.4 | 6.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.3 | 1.3 | GO:0045098 | type III intermediate filament(GO:0045098) |
0.3 | 2.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.1 | 1.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.1 | 0.6 | GO:0001533 | cornified envelope(GO:0001533) |
0.1 | 0.6 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
0.1 | 2.3 | GO:0000421 | autophagosome membrane(GO:0000421) |
0.1 | 4.8 | GO:0005776 | autophagosome(GO:0005776) |
0.1 | 3.2 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
0.0 | 0.3 | GO:0042382 | paraspeckles(GO:0042382) |
0.0 | 0.2 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
0.0 | 0.3 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
0.0 | 0.9 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
0.0 | 1.0 | GO:0031201 | SNARE complex(GO:0031201) |
0.0 | 0.4 | GO:0005686 | U2 snRNP(GO:0005686) |
0.0 | 8.0 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
0.0 | 1.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.0 | 0.2 | GO:0000124 | SAGA complex(GO:0000124) |
0.0 | 5.7 | GO:0005635 | nuclear envelope(GO:0005635) |
0.0 | 1.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.0 | 0.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.2 | 6.5 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) |
0.7 | 2.2 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
0.7 | 2.0 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
0.5 | 2.6 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
0.3 | 1.6 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
0.3 | 2.3 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
0.3 | 1.3 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
0.2 | 1.0 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
0.2 | 2.9 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.2 | 1.2 | GO:0070330 | aromatase activity(GO:0070330) |
0.2 | 2.2 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
0.2 | 0.9 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.2 | 0.6 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
0.1 | 0.9 | GO:0050786 | RAGE receptor binding(GO:0050786) |
0.1 | 1.1 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
0.1 | 3.3 | GO:0030506 | ankyrin binding(GO:0030506) |
0.1 | 1.5 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
0.1 | 0.4 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
0.1 | 0.8 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
0.1 | 0.3 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
0.1 | 2.1 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
0.1 | 0.6 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
0.1 | 1.1 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
0.1 | 1.3 | GO:0019215 | intermediate filament binding(GO:0019215) |
0.1 | 0.2 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
0.1 | 0.3 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
0.1 | 0.3 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
0.1 | 0.6 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
0.1 | 0.5 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
0.0 | 0.2 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
0.0 | 0.4 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.0 | 2.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
0.0 | 0.1 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
0.0 | 0.6 | GO:0035380 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677) |
0.0 | 2.0 | GO:0051213 | dioxygenase activity(GO:0051213) |
0.0 | 0.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.0 | 0.3 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
0.0 | 1.9 | GO:0043130 | ubiquitin binding(GO:0043130) |
0.0 | 0.8 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.0 | 1.5 | GO:0019905 | syntaxin binding(GO:0019905) |
0.0 | 2.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
0.0 | 1.3 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
0.0 | 0.3 | GO:0044653 | trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859) |
0.0 | 1.1 | GO:0030674 | protein binding, bridging(GO:0030674) |