Motif ID: Nr1h2

Z-value: 1.039


Transcription factors associated with Nr1h2:

Gene SymbolEntrez IDGene Name
Nr1h2 ENSMUSG00000060601.6 Nr1h2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_445539550.815.6e-07Click!


Activity profile for motif Nr1h2.

activity profile for motif Nr1h2


Sorted Z-values histogram for motif Nr1h2

Sorted Z-values for motif Nr1h2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h2

PNG image of the network

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Top targets:


Showing 1 to 20 of 129 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_53159885 6.457 ENSMUST00000030010.3
Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_-_97417730 6.205 ENSMUST00000043077.7
Thrsp
thyroid hormone responsive
chr10_-_109823585 5.373 ENSMUST00000161582.1
Nav3
neuron navigator 3
chr8_-_84773381 4.890 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr6_+_90462562 4.516 ENSMUST00000032174.5
Klf15
Kruppel-like factor 15
chr5_-_100159261 3.552 ENSMUST00000139520.1
Tmem150c
transmembrane protein 150C
chr7_-_27446599 3.330 ENSMUST00000011895.7
Sptbn4
spectrin beta, non-erythrocytic 4
chrX_-_53608979 3.161 ENSMUST00000123034.1
Gm14597
predicted gene 14597
chr5_+_123015010 2.850 ENSMUST00000121652.1
ENSMUST00000051016.4
Orai1

ORAI calcium release-activated calcium modulator 1

chr2_-_113829069 2.766 ENSMUST00000024005.7
Scg5
secretogranin V
chr11_+_55098104 2.618 ENSMUST00000000608.7
Gm2a
GM2 ganglioside activator protein
chr2_+_155276297 2.344 ENSMUST00000029128.3
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr1_-_164458345 2.170 ENSMUST00000027863.7
Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr5_+_107331157 2.082 ENSMUST00000031215.8
ENSMUST00000112677.3
Brdt

bromodomain, testis-specific

chr5_-_120588613 2.001 ENSMUST00000046426.8
Tpcn1
two pore channel 1
chr2_+_156420837 1.849 ENSMUST00000103137.3
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr16_+_13940630 1.816 ENSMUST00000141971.1
ENSMUST00000124947.1
ENSMUST00000023360.7
ENSMUST00000143697.1
Mpv17l



Mpv17 transgene, kidney disease mutant-like



chr2_+_156421083 1.760 ENSMUST00000125153.2
ENSMUST00000103136.1
ENSMUST00000109577.2
Epb4.1l1


erythrocyte protein band 4.1-like 1


chr18_+_37333853 1.717 ENSMUST00000061717.2
Pcdhb6
protocadherin beta 6
chr7_+_112953955 1.708 ENSMUST00000182858.1
Rassf10
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 6.5 GO:0055099 regulation of Cdc42 protein signal transduction(GO:0032489) response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.2 6.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.3 4.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 4.5 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 3.9 GO:0010508 positive regulation of autophagy(GO:0010508)
0.6 3.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 2.9 GO:0002115 store-operated calcium entry(GO:0002115)
0.5 2.8 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 2.8 GO:0016486 peptide hormone processing(GO:0016486)
0.5 2.6 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.2 2.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.7 2.2 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.5 2.2 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.2 2.1 GO:0007141 male meiosis I(GO:0007141)
0.4 1.8 GO:0010730 negative regulation of hydrogen peroxide metabolic process(GO:0010727) negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.2 1.6 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.1 1.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 1.5 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 1.5 GO:1901998 toxin transport(GO:1901998)
0.2 1.3 GO:1900194 negative regulation of oocyte maturation(GO:1900194)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.4 6.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 5.7 GO:0005635 nuclear envelope(GO:0005635)
0.1 4.8 GO:0005776 autophagosome(GO:0005776)
0.6 3.3 GO:0008091 spectrin(GO:0008091)
0.1 3.2 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 2.3 GO:0000421 autophagosome membrane(GO:0000421)
0.3 2.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 1.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 1.3 GO:0045098 type III intermediate filament(GO:0045098)
0.1 1.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.0 GO:0031201 SNARE complex(GO:0031201)
0.0 0.9 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 0.6 GO:0001533 cornified envelope(GO:0001533)
0.1 0.6 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 6.5 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.1 3.3 GO:0030506 ankyrin binding(GO:0030506)
0.2 2.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 2.8 GO:0051082 unfolded protein binding(GO:0051082)
0.5 2.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 2.5 GO:0017124 SH3 domain binding(GO:0017124)
0.3 2.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.7 2.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 2.2 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.1 2.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.7 2.0 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 2.0 GO:0051213 dioxygenase activity(GO:0051213)
0.0 1.9 GO:0043130 ubiquitin binding(GO:0043130)
0.3 1.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 1.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 1.5 GO:0019905 syntaxin binding(GO:0019905)
0.3 1.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 1.3 GO:0019215 intermediate filament binding(GO:0019215)
0.0 1.3 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.2 1.2 GO:0070330 aromatase activity(GO:0070330)