Motif ID: Nr2f1_Nr4a1

Z-value: 1.704

Transcription factors associated with Nr2f1_Nr4a1:

Gene SymbolEntrez IDGene Name
Nr2f1 ENSMUSG00000069171.7 Nr2f1
Nr4a1 ENSMUSG00000023034.6 Nr4a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a1mm10_v2_chr15_+_101266839_101266859-0.572.5e-03Click!
Nr2f1mm10_v2_chr13_-_78199757_781998550.145.1e-01Click!


Activity profile for motif Nr2f1_Nr4a1.

activity profile for motif Nr2f1_Nr4a1


Sorted Z-values histogram for motif Nr2f1_Nr4a1

Sorted Z-values for motif Nr2f1_Nr4a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f1_Nr4a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_119578981 12.114 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr18_+_57142782 9.009 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr1_+_166254095 8.537 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr1_+_12718496 8.507 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chrX_+_153006461 6.955 ENSMUST00000095755.3
 Usp51
ubiquitin specific protease 51
chr17_+_43952999 6.937 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr10_+_128194446 6.661 ENSMUST00000044776.6
 Gls2
glutaminase 2 (liver, mitochondrial)
chr5_+_111581422 5.827 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr8_-_105471481 5.416 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr3_-_138131356 5.355 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr11_-_100822525 5.335 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr6_+_113531675 5.215 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr11_+_70657196 5.183 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr11_+_70657687 5.170 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr17_+_17831004 5.158 ENSMUST00000172097.2
 4930546H06Rik
RIKEN cDNA 4930546H06 gene
chr9_-_54661666 5.141 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_-_109616548 4.876 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr3_+_51693771 4.771 ENSMUST00000099104.2
 Gm10729
predicted gene 10729
chr1_+_191821444 4.450 ENSMUST00000027931.7
 Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr11_-_70656467 4.349 ENSMUST00000131642.1
 Gm12319
predicted gene 12319

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 371 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 12.1 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during SA node cell action potential(GO:0086046)
3.0 11.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 9.4 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
1.8 9.0 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.3 8.4 GO:0016578 histone deubiquitination(GO:0016578)
2.7 8.1 GO:0042822 vitamin B6 metabolic process(GO:0042816) pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.4 7.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
1.4 7.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 7.2 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 6.6 GO:0051384 response to glucocorticoid(GO:0051384)
0.5 6.4 GO:0033572 transferrin transport(GO:0033572)
1.0 6.0 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 5.9 GO:0014003 oligodendrocyte development(GO:0014003)
1.0 5.8 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 5.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
1.8 5.3 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
1.0 5.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.7 5.2 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.6 5.2 GO:0006105 succinate metabolic process(GO:0006105)
0.3 5.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.4 GO:0005730 nucleolus(GO:0005730)
0.1 18.0 GO:0000793 condensed chromosome(GO:0000793)
0.0 17.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 14.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 14.4 GO:0005654 nucleoplasm(GO:0005654)
0.1 10.4 GO:0016605 PML body(GO:0016605)
0.6 9.9 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
1.8 9.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 8.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.7 8.1 GO:0000124 SAGA complex(GO:0000124)
0.0 8.0 GO:0031012 extracellular matrix(GO:0031012)
0.2 7.9 GO:0098803 respiratory chain complex(GO:0098803)
0.2 7.0 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.7 6.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 6.4 GO:0031528 microvillus membrane(GO:0031528)
0.4 6.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
1.2 6.0 GO:0005861 troponin complex(GO:0005861)
0.2 6.0 GO:0001891 phagocytic cup(GO:0001891)
1.9 5.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.6 5.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 265 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.0 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.1 13.4 GO:0001047 core promoter binding(GO:0001047)
2.4 11.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 10.5 GO:0005109 frizzled binding(GO:0005109)
1.4 9.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.0 9.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.8 8.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 8.2 GO:0003924 GTPase activity(GO:0003924)
2.7 8.1 GO:0031403 lithium ion binding(GO:0031403)
0.1 7.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 7.3 GO:0003735 structural constituent of ribosome(GO:0003735)
1.4 7.2 GO:0004359 glutaminase activity(GO:0004359)
1.2 6.9 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
1.3 6.7 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.1 6.6 GO:0033142 progesterone receptor binding(GO:0033142)
0.2 6.6 GO:0032452 histone demethylase activity(GO:0032452)
2.2 6.5 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 6.1 GO:0042826 histone deacetylase binding(GO:0042826)
2.0 6.0 GO:0030172 troponin C binding(GO:0030172)
0.0 6.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)