Motif ID: Nr4a2

Z-value: 0.626


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57113053_571130720.413.6e-02Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 108 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 3.328 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr8_+_68880491 1.894 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr2_+_75832168 1.739 ENSMUST00000047232.7
ENSMUST00000111952.2
 Agps

alkylglycerone phosphate synthase

chr5_+_111581422 1.615 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr2_+_105668888 1.504 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr15_-_42676967 1.482 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr9_-_32344237 1.465 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr11_-_100822525 1.424 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr11_-_52282564 1.398 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr2_+_105668935 1.358 ENSMUST00000142772.1
 Pax6
paired box gene 6
chrX_-_48513518 1.310 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr6_-_124814288 1.241 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chr10_-_40302186 1.227 ENSMUST00000099945.4
 Amd1
S-adenosylmethionine decarboxylase 1
chr18_+_57142782 1.194 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr16_+_44139821 1.173 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
 Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr9_-_13446753 1.105 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr11_+_70657687 1.100 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chrX_-_142390334 1.054 ENSMUST00000112907.1
 Acsl4
acyl-CoA synthetase long-chain family member 4
chr11_+_70657196 0.987 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr18_+_86711059 0.952 ENSMUST00000068423.3
 Cbln2
cerebellin 2 precursor protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.9 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.0 2.1 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.5 1.9 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.6 1.8 GO:0006597 spermine biosynthetic process(GO:0006597)
0.5 1.5 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.1 1.5 GO:0010107 potassium ion import(GO:0010107)
0.5 1.4 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.2 1.4 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.2 1.3 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.0 1.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.4 1.2 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 1.2 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.2 1.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 1.1 GO:0032306 regulation of prostaglandin secretion(GO:0032306) embryonic process involved in female pregnancy(GO:0060136)
0.1 0.9 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.9 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.9 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 0.8 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.8 GO:0045947 negative regulation of translational initiation(GO:0045947)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 1.9 GO:0042627 chylomicron(GO:0042627)
0.0 1.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 1.5 GO:0031415 NatA complex(GO:0031415)
0.0 1.5 GO:0030315 T-tubule(GO:0030315)
0.0 1.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.4 1.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 1.2 GO:0001891 phagocytic cup(GO:0001891)
0.2 1.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.3 0.9 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.0 0.9 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 0.8 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)
0.0 0.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.7 GO:0016528 sarcoplasm(GO:0016528)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.9 GO:0003680 AT DNA binding(GO:0003680)
0.2 2.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.5 1.8 GO:0019808 polyamine binding(GO:0019808)
0.0 1.7 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 1.6 GO:0005518 collagen binding(GO:0005518)
0.3 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 1.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 1.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 1.1 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 0.9 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.9 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.3 0.8 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.1 0.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)