Motif ID: Nr4a3

Z-value: 0.456


Transcription factors associated with Nr4a3:

Gene SymbolEntrez IDGene Name
Nr4a3 ENSMUSG00000028341.3 Nr4a3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a3mm10_v2_chr4_+_48045144_480451600.627.3e-04Click!


Activity profile for motif Nr4a3.

activity profile for motif Nr4a3


Sorted Z-values histogram for motif Nr4a3

Sorted Z-values for motif Nr4a3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_124793013 1.691 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr8_+_124793061 1.660 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr5_+_66968416 1.565 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr11_-_55033398 1.417 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr5_+_66968559 1.228 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chrY_-_1245685 1.108 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr11_+_113619318 0.963 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr11_-_115267236 0.711 ENSMUST00000106554.1
 Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
chr17_-_35910032 0.699 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chrY_-_1245753 0.669 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr6_-_113531575 0.662 ENSMUST00000032425.5
 Emc3
ER membrane protein complex subunit 3
chr15_-_79804717 0.642 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr6_-_137571007 0.634 ENSMUST00000100841.2
 Eps8
epidermal growth factor receptor pathway substrate 8
chr7_-_98162318 0.607 ENSMUST00000107112.1
 Capn5
calpain 5
chr17_-_35909626 0.593 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr2_+_92375306 0.560 ENSMUST00000028650.8
 Pex16
peroxisomal biogenesis factor 16
chr7_+_45896941 0.542 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr9_-_64341145 0.537 ENSMUST00000120760.1
ENSMUST00000168844.2
 Dis3l

DIS3 mitotic control homolog (S. cerevisiae)-like

chr19_+_44989073 0.516 ENSMUST00000026225.8
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr7_+_45897429 0.484 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr2_+_178141920 0.463 ENSMUST00000103066.3
 Phactr3
phosphatase and actin regulator 3
chr14_-_21848924 0.451 ENSMUST00000124549.1
 Comtd1
catechol-O-methyltransferase domain containing 1
chr12_-_93929102 0.451 ENSMUST00000180321.1
 Gm9726
predicted gene 9726
chr11_-_61494173 0.444 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
 Mapk7


mitogen-activated protein kinase 7


chr11_+_116657106 0.423 ENSMUST00000116318.2
 Gm11744
predicted gene 11744
chr8_+_119862239 0.401 ENSMUST00000034287.8
 Klhl36
kelch-like 36
chr19_-_37207293 0.379 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr5_+_16553488 0.377 ENSMUST00000030683.3
 Hgf
hepatocyte growth factor
chr4_+_116075269 0.376 ENSMUST00000030471.8
 Lrrc41
leucine rich repeat containing 41
chr2_-_167492826 0.373 ENSMUST00000109211.2
ENSMUST00000057627.9
 Spata2

spermatogenesis associated 2

chr4_-_43578824 0.373 ENSMUST00000030189.7
 Gba2
glucosidase beta 2
chr19_-_45998479 0.363 ENSMUST00000045396.7
 9130011E15Rik
RIKEN cDNA 9130011E15 gene
chr3_-_59210881 0.354 ENSMUST00000040622.1
 P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr15_-_79141197 0.344 ENSMUST00000169604.1
 1700088E04Rik
RIKEN cDNA 1700088E04 gene
chr4_-_116075022 0.333 ENSMUST00000050580.4
ENSMUST00000078676.5
 Uqcrh

ubiquinol-cytochrome c reductase hinge protein

chr16_+_10545390 0.328 ENSMUST00000115827.1
ENSMUST00000038145.6
ENSMUST00000150894.1
 Clec16a


C-type lectin domain family 16, member A


chr16_+_10545339 0.314 ENSMUST00000066345.7
ENSMUST00000115824.3
ENSMUST00000155633.1
 Clec16a


C-type lectin domain family 16, member A


chr16_-_4523056 0.312 ENSMUST00000090500.3
ENSMUST00000023161.7
 Srl

sarcalumenin

chr7_-_79842287 0.311 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase
chr9_-_22085391 0.310 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
 Ecsit



ECSIT homolog (Drosophila)



chr3_-_89773221 0.309 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr8_-_123894736 0.308 ENSMUST00000034453.4
 Acta1
actin, alpha 1, skeletal muscle
chr11_+_115475645 0.303 ENSMUST00000035240.6
 Armc7
armadillo repeat containing 7
chr4_-_139131058 0.297 ENSMUST00000143971.1
 Minos1
mitochondrial inner membrane organizing system 1
chr15_-_76918010 0.291 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr8_-_120668058 0.283 ENSMUST00000181950.1
ENSMUST00000181333.1
 Emc8
Gm27021
ER membrane protein complex subunit 8
predicted gene, 27021
chr11_-_72266596 0.263 ENSMUST00000021161.6
ENSMUST00000140167.1
 Slc13a5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr11_+_70764209 0.262 ENSMUST00000060444.5
 Zfp3
zinc finger protein 3
chr9_+_22003035 0.259 ENSMUST00000115331.2
ENSMUST00000003493.7
 Prkcsh

protein kinase C substrate 80K-H

chr1_+_75435930 0.257 ENSMUST00000037796.7
ENSMUST00000113584.1
ENSMUST00000145166.1
ENSMUST00000143730.1
ENSMUST00000133418.1
ENSMUST00000144874.1
ENSMUST00000140287.1
 Gmppa






GDP-mannose pyrophosphorylase A






chr18_-_60624304 0.232 ENSMUST00000097566.3
 Synpo
synaptopodin
chr17_+_34605855 0.231 ENSMUST00000037489.8
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr4_-_150914401 0.202 ENSMUST00000105675.1
 Park7
Parkinson disease (autosomal recessive, early onset) 7
chr4_+_131873608 0.189 ENSMUST00000053819.3
 Srsf4
serine/arginine-rich splicing factor 4
chr2_-_165283599 0.178 ENSMUST00000155289.1
 Slc35c2
solute carrier family 35, member C2
chr10_-_20725023 0.173 ENSMUST00000020165.7
 Pde7b
phosphodiesterase 7B
chr2_-_180273488 0.170 ENSMUST00000108891.1
 Cables2
CDK5 and Abl enzyme substrate 2
chr11_+_90638127 0.165 ENSMUST00000020851.8
 Cox11
cytochrome c oxidase assembly protein 11
chr19_+_46152505 0.160 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chr7_+_30712209 0.159 ENSMUST00000005692.6
ENSMUST00000170371.1
 Atp4a

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

chr7_+_102267795 0.158 ENSMUST00000033289.4
 Stim1
stromal interaction molecule 1
chr2_+_68117713 0.155 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr8_+_120668222 0.152 ENSMUST00000034276.6
ENSMUST00000181586.1
 Cox4i1

cytochrome c oxidase subunit IV isoform 1

chrX_+_56447965 0.149 ENSMUST00000079663.6
 Gm2174
predicted gene 2174
chr8_+_120668308 0.143 ENSMUST00000181795.1
 Cox4i1
cytochrome c oxidase subunit IV isoform 1
chr15_+_100761741 0.142 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr1_+_36691487 0.131 ENSMUST00000081180.4
 Cox5b
cytochrome c oxidase subunit Vb
chr1_-_152386589 0.128 ENSMUST00000162371.1
 Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
chrX_+_101299143 0.128 ENSMUST00000118111.1
ENSMUST00000130555.1
ENSMUST00000151528.1
 Nlgn3


neuroligin 3


chr7_-_19715395 0.126 ENSMUST00000032555.9
ENSMUST00000093552.5
 Tomm40

translocase of outer mitochondrial membrane 40 homolog (yeast)

chrX_+_101299207 0.106 ENSMUST00000065858.2
 Nlgn3
neuroligin 3
chr15_-_102516806 0.105 ENSMUST00000169162.1
ENSMUST00000023812.2
ENSMUST00000165174.1
ENSMUST00000169367.1
ENSMUST00000169377.1
 Map3k12




mitogen-activated protein kinase kinase kinase 12




chrX_-_71492799 0.091 ENSMUST00000037391.5
ENSMUST00000114586.2
ENSMUST00000114587.2
 Cd99l2


CD99 antigen-like 2


chr8_-_120668121 0.090 ENSMUST00000034277.7
 Emc8
ER membrane protein complex subunit 8
chr4_+_134397380 0.089 ENSMUST00000105870.1
 Pafah2
platelet-activating factor acetylhydrolase 2
chr13_-_73328442 0.081 ENSMUST00000022097.5
 Ndufs6
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr11_-_3504766 0.079 ENSMUST00000044507.5
 Inpp5j
inositol polyphosphate 5-phosphatase J
chr7_-_28598140 0.072 ENSMUST00000108283.1
ENSMUST00000040531.8
 Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr3_-_95133989 0.060 ENSMUST00000172572.2
ENSMUST00000173462.2
 Scnm1

sodium channel modifier 1

chr9_-_70141484 0.055 ENSMUST00000034749.8
 Fam81a
family with sequence similarity 81, member A
chr7_-_79466167 0.044 ENSMUST00000073889.7
 Polg
polymerase (DNA directed), gamma
chr2_-_59160644 0.021 ENSMUST00000077687.5
 Ccdc148
coiled-coil domain containing 148
chr1_+_93215899 0.018 ENSMUST00000138595.1
 E030010N08Rik
RIKEN cDNA E030010N08 gene
chr3_-_89213840 0.009 ENSMUST00000173477.1
ENSMUST00000119222.1
 Mtx1

metaxin 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 1.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 0.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 0.6 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.4 GO:0070375 ERK5 cascade(GO:0070375)
0.1 3.4 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 0.4 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.1 1.0 GO:0030432 peristalsis(GO:0030432)
0.1 0.6 GO:1901524 regulation of autophagosome maturation(GO:1901096) regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525)
0.1 0.3 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1 0.6 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.1 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.4 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
0.1 0.4 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.1 0.2 GO:0050787 glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) glyoxal catabolic process(GO:1903190) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) positive regulation of androgen receptor activity(GO:2000825)
0.1 0.3 GO:0006842 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746)
0.1 0.3 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.1 1.4 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 0.5 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.2 GO:0015786 UDP-glucose transport(GO:0015786)
0.0 0.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.2 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.0 0.3 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.7 GO:0001964 startle response(GO:0001964)
0.0 0.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.2 GO:0010155 regulation of proton transport(GO:0010155)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 2.9 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.5 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 0.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.1 1.0 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.4 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 0.6 GO:0001847 opsonin receptor activity(GO:0001847)
0.2 1.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.4 GO:0004348 glucosylceramidase activity(GO:0004348)
0.1 0.3 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.1 0.2 GO:0044388 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) small protein activating enzyme binding(GO:0044388) cupric ion binding(GO:1903135) cuprous ion binding(GO:1903136) glyoxalase (glycolic acid-forming) activity(GO:1990422)
0.1 0.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.2 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.0 0.2 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 1.3 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.4 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)