Motif ID: Nr4a3

Z-value: 0.456


Transcription factors associated with Nr4a3:

Gene SymbolEntrez IDGene Name
Nr4a3 ENSMUSG00000028341.3 Nr4a3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a3mm10_v2_chr4_+_48045144_480451600.627.3e-04Click!


Activity profile for motif Nr4a3.

activity profile for motif Nr4a3


Sorted Z-values histogram for motif Nr4a3

Sorted Z-values for motif Nr4a3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a3

PNG image of the network

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Top targets:


Showing 1 to 20 of 84 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_124793013 1.691 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr8_+_124793061 1.660 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr5_+_66968416 1.565 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr11_-_55033398 1.417 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr5_+_66968559 1.228 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chrY_-_1245685 1.108 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr11_+_113619318 0.963 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr11_-_115267236 0.711 ENSMUST00000106554.1
 Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
chr17_-_35910032 0.699 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chrY_-_1245753 0.669 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr6_-_113531575 0.662 ENSMUST00000032425.5
 Emc3
ER membrane protein complex subunit 3
chr15_-_79804717 0.642 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr6_-_137571007 0.634 ENSMUST00000100841.2
 Eps8
epidermal growth factor receptor pathway substrate 8
chr7_-_98162318 0.607 ENSMUST00000107112.1
 Capn5
calpain 5
chr17_-_35909626 0.593 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr2_+_92375306 0.560 ENSMUST00000028650.8
 Pex16
peroxisomal biogenesis factor 16
chr7_+_45896941 0.542 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr9_-_64341145 0.537 ENSMUST00000120760.1
ENSMUST00000168844.2
 Dis3l

DIS3 mitotic control homolog (S. cerevisiae)-like

chr19_+_44989073 0.516 ENSMUST00000026225.8
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr7_+_45897429 0.484 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 2.9 GO:0031032 actomyosin structure organization(GO:0031032)
0.2 1.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 1.4 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.4 1.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 1.0 GO:0030432 peristalsis(GO:0030432)
0.2 0.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.7 GO:0001964 startle response(GO:0001964)
0.2 0.6 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.6 GO:1901524 regulation of autophagosome maturation(GO:1901096) regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525)
0.1 0.6 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.5 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.5 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.1 0.4 GO:0070375 ERK5 cascade(GO:0070375)
0.1 0.4 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.1 0.4 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
0.1 0.4 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.0 0.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 0.3 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1 0.3 GO:0006842 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0031902 late endosome membrane(GO:0031902)
0.2 1.3 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.0 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.3 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.3 1.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 0.6 GO:0001847 opsonin receptor activity(GO:0001847)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.4 GO:0004348 glucosylceramidase activity(GO:0004348)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.3 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.2 GO:0044388 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) small protein activating enzyme binding(GO:0044388) cupric ion binding(GO:1903135) cuprous ion binding(GO:1903136) glyoxalase (glycolic acid-forming) activity(GO:1990422)