Motif ID: Nr6a1

Z-value: 0.440


Transcription factors associated with Nr6a1:

Gene SymbolEntrez IDGene Name
Nr6a1 ENSMUSG00000063972.7 Nr6a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_389264540.442.5e-02Click!


Activity profile for motif Nr6a1.

activity profile for motif Nr6a1


Sorted Z-values histogram for motif Nr6a1

Sorted Z-values for motif Nr6a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr6a1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_30314810 1.184 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
 Syne4



spectrin repeat containing, nuclear envelope family member 4



chr7_-_66427469 0.898 ENSMUST00000015278.7
 Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr11_-_60811228 0.892 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr12_+_3807017 0.804 ENSMUST00000020991.8
ENSMUST00000172509.1
 Dnmt3a

DNA methyltransferase 3A

chr13_-_24761440 0.778 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr14_+_12189943 0.763 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr2_+_172472512 0.744 ENSMUST00000029007.2
 Fam209
family with sequence similarity 209
chr6_+_83349446 0.635 ENSMUST00000136501.1
 Bola3
bolA-like 3 (E. coli)
chr12_+_3807076 0.621 ENSMUST00000174817.1
 Dnmt3a
DNA methyltransferase 3A
chr1_-_151428440 0.609 ENSMUST00000064771.5
 Swt1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr1_+_131970589 0.583 ENSMUST00000027695.6
 Slc45a3
solute carrier family 45, member 3
chr5_-_137610626 0.557 ENSMUST00000142675.1
 Pcolce
procollagen C-endopeptidase enhancer protein
chr5_-_30073554 0.544 ENSMUST00000026846.6
 Tyms
thymidylate synthase
chr18_-_77767752 0.493 ENSMUST00000048192.7
 Haus1
HAUS augmin-like complex, subunit 1
chr15_-_73184840 0.461 ENSMUST00000044113.10
 Ago2
argonaute RISC catalytic subunit 2
chr8_+_75109528 0.452 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr5_-_5694024 0.429 ENSMUST00000115425.2
ENSMUST00000115427.1
ENSMUST00000115424.2
ENSMUST00000015797.4
 Steap2



six transmembrane epithelial antigen of prostate 2



chr9_-_50603792 0.397 ENSMUST00000000175.4
 Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
chr5_-_5694559 0.391 ENSMUST00000115426.2
 Steap2
six transmembrane epithelial antigen of prostate 2
chr3_+_138526174 0.388 ENSMUST00000029803.7
 Eif4e
eukaryotic translation initiation factor 4E
chr15_-_98165613 0.386 ENSMUST00000143400.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr6_+_42245907 0.371 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr19_+_46707443 0.357 ENSMUST00000003655.7
 As3mt
arsenic (+3 oxidation state) methyltransferase
chr9_-_96437434 0.342 ENSMUST00000070500.2
 BC043934
cDNA sequence BC043934
chr15_-_98165560 0.333 ENSMUST00000123922.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr17_+_72918298 0.325 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr12_-_115790884 0.322 ENSMUST00000081809.5
 Ighv1-73
immunoglobulin heavy variable 1-73
chr10_+_128083273 0.308 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr4_+_123904832 0.308 ENSMUST00000030400.7
 Mycbp
c-myc binding protein
chr7_-_145283915 0.302 ENSMUST00000058022.4
 Tpcn2
two pore segment channel 2
chr9_-_121839460 0.298 ENSMUST00000135986.2
 Ccdc13
coiled-coil domain containing 13
chr1_+_151428612 0.286 ENSMUST00000065625.5
 Trmt1l
tRNA methyltransferase 1 like
chr9_+_50603892 0.284 ENSMUST00000044051.4
 Timm8b
translocase of inner mitochondrial membrane 8B
chr7_-_130772652 0.257 ENSMUST00000057134.4
 Etos1
ectopic ossification 1
chr2_+_177768044 0.254 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chr9_+_98296556 0.249 ENSMUST00000035031.6
ENSMUST00000112935.1
 Nmnat3

nicotinamide nucleotide adenylyltransferase 3

chr13_-_25020289 0.232 ENSMUST00000021772.2
 Mrs2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr14_+_78849171 0.217 ENSMUST00000040990.5
 Vwa8
von Willebrand factor A domain containing 8
chr10_-_80855187 0.209 ENSMUST00000035775.8
 Lsm7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr8_-_109693235 0.209 ENSMUST00000034164.4
 Ist1
increased sodium tolerance 1 homolog (yeast)
chr13_+_58281183 0.207 ENSMUST00000180882.1
ENSMUST00000180452.1
 Gm26555

predicted gene, 26555

chr17_+_26123514 0.202 ENSMUST00000025014.8
 Mrpl28
mitochondrial ribosomal protein L28
chr6_+_48593927 0.201 ENSMUST00000135151.1
 Repin1
replication initiator 1
chr7_+_133637543 0.195 ENSMUST00000051169.6
 2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr7_+_133637686 0.187 ENSMUST00000128901.2
 2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr11_+_6560183 0.180 ENSMUST00000109722.2
 Ccm2
cerebral cavernous malformation 2
chr12_-_71136611 0.180 ENSMUST00000021486.8
ENSMUST00000166120.1
 Timm9

translocase of inner mitochondrial membrane 9

chr14_-_121505247 0.173 ENSMUST00000088386.6
 Slc15a1
solute carrier family 15 (oligopeptide transporter), member 1
chr5_-_137611429 0.167 ENSMUST00000031731.7
 Pcolce
procollagen C-endopeptidase enhancer protein
chr17_-_46645128 0.150 ENSMUST00000003642.6
 Klc4
kinesin light chain 4
chr4_+_123904907 0.130 ENSMUST00000106202.3
 Mycbp
c-myc binding protein
chr5_-_137611372 0.126 ENSMUST00000054564.6
 Pcolce
procollagen C-endopeptidase enhancer protein
chr4_-_45530330 0.118 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr11_-_69822144 0.118 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr7_+_128265675 0.116 ENSMUST00000118169.1
ENSMUST00000142841.1
 Slc5a2

solute carrier family 5 (sodium/glucose cotransporter), member 2

chr7_-_105574324 0.108 ENSMUST00000081165.7
 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr2_+_180071793 0.105 ENSMUST00000108901.1
 Mtg2
mitochondrial ribosome associated GTPase 2
chr2_+_176431829 0.061 ENSMUST00000172025.1
 Gm14435
predicted gene 14435
chr4_+_155562348 0.053 ENSMUST00000030939.7
 Nadk
NAD kinase
chr2_+_173737492 0.046 ENSMUST00000067530.4
 Vapb
vesicle-associated membrane protein, associated protein B and C
chr4_-_123904826 0.044 ENSMUST00000181292.1
 Gm26606
predicted gene, 26606
chr14_+_58072686 0.038 ENSMUST00000022545.7
 Fgf9
fibroblast growth factor 9
chr9_+_87144285 0.032 ENSMUST00000113149.1
ENSMUST00000143779.1
ENSMUST00000179313.1
ENSMUST00000049457.7
ENSMUST00000153444.1
 Mrap2




melanocortin 2 receptor accessory protein 2




chr15_+_100038635 0.029 ENSMUST00000100203.3
 Dip2b
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr9_+_122805524 0.029 ENSMUST00000052740.7
 Tcaim
T cell activation inhibitor, mitochondrial
chr4_-_125065603 0.025 ENSMUST00000036383.3
 Dnali1
dynein, axonemal, light intermediate polypeptide 1
chr2_+_157424255 0.013 ENSMUST00000029175.7
ENSMUST00000092576.4
 Src

Rous sarcoma oncogene

chr19_-_5688149 0.012 ENSMUST00000068169.5
 Pcnxl3
pecanex-like 3 (Drosophila)
chr10_-_43540945 0.007 ENSMUST00000147196.1
ENSMUST00000019932.3
 1700021F05Rik

RIKEN cDNA 1700021F05 gene

chr4_-_134552122 0.001 ENSMUST00000060435.6
 Sepn1
selenoprotein N, 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.3 0.9 GO:0060166 olfactory pit development(GO:0060166)
0.3 0.8 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.2 0.6 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2 1.4 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 1.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.3 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.5 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.1 0.2 GO:0009838 abscission(GO:0009838)
0.1 0.2 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.4 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.4 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.8 GO:1901998 toxin transport(GO:1901998)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.8 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.0 GO:0044830 activation of signaling protein activity involved in unfolded protein response(GO:0006987) modulation by host of viral RNA genome replication(GO:0044830)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.5 GO:0070578 RISC-loading complex(GO:0070578)
0.1 0.4 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 1.4 GO:0001741 XY body(GO:0001741)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)
0.0 0.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.1 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) serine binding(GO:0070905)
0.3 0.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 0.6 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 0.9 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 1.4 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.2 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.3 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.4 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 0.2 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0005542 folic acid binding(GO:0005542)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.9 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.4 GO:0015035 glutathione peroxidase activity(GO:0004602) protein disulfide oxidoreductase activity(GO:0015035)
0.0 1.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.0 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)