Motif ID: Nrf1

Z-value: 3.104


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30047979_300480490.672.1e-04Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_79682304 6.098 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr15_+_88751649 5.597 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr2_+_168081004 5.554 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr11_-_69921329 4.785 ENSMUST00000108613.3
ENSMUST00000043419.3
ENSMUST00000070996.4
 Eif5a


eukaryotic translation initiation factor 5A


chr19_+_41911851 4.714 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr2_-_157135112 4.689 ENSMUST00000139263.1
 Samhd1
SAM domain and HD domain, 1
chr2_-_157135200 4.671 ENSMUST00000109549.2
ENSMUST00000088523.4
ENSMUST00000057725.3
 Samhd1


SAM domain and HD domain, 1


chr8_+_122568001 4.575 ENSMUST00000006760.2
 Cdt1
chromatin licensing and DNA replication factor 1
chr11_-_11808923 4.398 ENSMUST00000109664.1
ENSMUST00000150714.1
ENSMUST00000047689.4
ENSMUST00000171938.1
ENSMUST00000171080.1
 Fignl1




fidgetin-like 1




chr10_+_79682169 4.300 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr13_-_53286052 4.297 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr6_-_126939524 4.247 ENSMUST00000144954.1
ENSMUST00000112221.1
ENSMUST00000112220.1
 Rad51ap1


RAD51 associated protein 1


chr11_-_33163072 4.051 ENSMUST00000093201.6
ENSMUST00000101375.4
ENSMUST00000109354.3
ENSMUST00000075641.3
 Npm1



nucleophosmin 1



chr2_-_157007039 4.018 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr11_+_40733936 3.933 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2
chr17_-_70849644 3.874 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr11_+_40733639 3.779 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr2_-_157007015 3.766 ENSMUST00000146413.1
 Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr14_-_20181773 3.761 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr6_+_66535390 3.750 ENSMUST00000116605.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 582 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.2 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 11.8 GO:0051301 cell division(GO:0051301)
1.8 10.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
1.0 10.2 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
1.4 9.9 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.2 9.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
2.3 9.4 GO:0006203 dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
1.3 9.3 GO:1904667 negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 8.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 6.6 GO:0006413 translational initiation(GO:0006413)
0.6 6.1 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.2 6.0 GO:0009299 mRNA transcription(GO:0009299)
0.1 5.6 GO:0051225 spindle assembly(GO:0051225)
0.3 5.5 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.2 5.5 GO:0043631 RNA polyadenylation(GO:0043631)
0.9 5.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.5 5.4 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.3 5.3 GO:0006270 DNA replication initiation(GO:0006270)
0.4 5.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.3 5.1 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 270 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 32.1 GO:0005730 nucleolus(GO:0005730)
0.1 19.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.2 15.6 GO:0005643 nuclear pore(GO:0005643)
1.3 12.9 GO:0005642 annulate lamellae(GO:0005642)
0.1 11.0 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 9.6 GO:0016363 nuclear matrix(GO:0016363)
0.6 8.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 8.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 7.9 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
1.3 7.8 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.4 7.7 GO:0016580 Sin3 complex(GO:0016580)
0.2 7.6 GO:0090544 BAF-type complex(GO:0090544)
0.1 7.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.5 7.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 6.4 GO:0001669 acrosomal vesicle(GO:0001669)
2.1 6.2 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.6 6.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 5.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.8 5.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.8 5.4 GO:0001940 male pronucleus(GO:0001940)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 343 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 63.2 GO:0044822 poly(A) RNA binding(GO:0044822)
1.1 14.6 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.0 12.5 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.2 12.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 10.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.8 10.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 9.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.8 9.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 9.0 GO:0035064 methylated histone binding(GO:0035064)
0.0 8.9 GO:0003723 RNA binding(GO:0003723)
0.2 8.7 GO:0003684 damaged DNA binding(GO:0003684)
0.8 8.0 GO:0001055 RNA polymerase II activity(GO:0001055)
0.7 7.5 GO:0030957 Tat protein binding(GO:0030957)
0.5 7.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 6.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 6.7 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.2 6.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 6.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.8 6.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.2 6.1 GO:0016749 N-succinyltransferase activity(GO:0016749)