Motif ID: Onecut1_Cux2
Z-value: 1.073
Transcription factors associated with Onecut1_Cux2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cux2 | ENSMUSG00000042589.12 | Cux2 |
| Cux2 | ENSMUSG00000072641.1 | Cux2 |
| Onecut1 | ENSMUSG00000043013.9 | Onecut1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Onecut1 | mm10_v2_chr9_+_74861888_74861921 | 0.71 | 5.5e-05 | Click! |
| Cux2 | mm10_v2_chr5_-_122049822_122049882 | -0.25 | 2.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 11.0 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 1.5 | 4.6 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 1.5 | 4.6 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 0.4 | 2.9 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
| 0.4 | 1.1 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.3 | 2.6 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.3 | 1.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 0.9 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.2 | 7.0 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.2 | 1.1 | GO:0021965 | spinal cord ventral commissure morphogenesis(GO:0021965) |
| 0.2 | 3.2 | GO:1902993 | positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993) |
| 0.1 | 0.5 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
| 0.1 | 1.1 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.1 | 2.1 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.1 | 0.4 | GO:0045896 | regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897) |
| 0.1 | 1.4 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.1 | 0.9 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 0.7 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.1 | 0.5 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.1 | 5.4 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 0.1 | 0.4 | GO:0003383 | apical constriction(GO:0003383) |
| 0.1 | 0.5 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.1 | GO:0030210 | heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014) |
| 0.0 | 0.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 0.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 0.1 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
| 0.0 | 0.2 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) negative regulation of DNA damage checkpoint(GO:2000002) |
| 0.0 | 0.1 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.0 | 0.2 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.8 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.0 | 3.1 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.0 | 0.5 | GO:0000154 | rRNA modification(GO:0000154) |
| 0.0 | 0.3 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 0.1 | GO:0050747 | positive regulation of lipoprotein metabolic process(GO:0050747) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.6 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.3 | 2.6 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.1 | 0.5 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.1 | 1.4 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 1.2 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 1.1 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 1.1 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.3 | GO:0044302 | dentate gyrus mossy fiber(GO:0044302) |
| 0.1 | 0.5 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 1.1 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 0.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.2 | GO:0044308 | axonal spine(GO:0044308) |
| 0.0 | 0.2 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 0.3 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.0 | 0.2 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 0.2 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 0.1 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.0 | 4.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.4 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 0.1 | GO:0042587 | glycogen granule(GO:0042587) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.8 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.2 | 4.6 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.2 | 1.1 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.1 | 7.0 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 2.6 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.1 | 0.5 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 4.5 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 1.1 | GO:0004889 | acetylcholine-activated cation-selective channel activity(GO:0004889) |
| 0.1 | 0.4 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.1 | 1.1 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 0.5 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 0.3 | GO:0070878 | primary miRNA binding(GO:0070878) |
| 0.1 | 0.7 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 0.5 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 10.6 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 1.2 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 2.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 3.2 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.2 | GO:0005451 | monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.7 | GO:0050694 | galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.0 | 0.1 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.0 | 0.3 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.3 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 0.1 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 10.2 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 1.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.4 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
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