Motif ID: Onecut2_Onecut3

Z-value: 0.627

Transcription factors associated with Onecut2_Onecut3:

Gene SymbolEntrez IDGene Name
Onecut2 ENSMUSG00000045991.12 Onecut2
Onecut3 ENSMUSG00000045518.8 Onecut3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut2mm10_v2_chr18_+_64340225_643403640.452.0e-02Click!
Onecut3mm10_v2_chr10_+_80494835_804948730.154.7e-01Click!


Activity profile for motif Onecut2_Onecut3.

activity profile for motif Onecut2_Onecut3


Sorted Z-values histogram for motif Onecut2_Onecut3

Sorted Z-values for motif Onecut2_Onecut3



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut2_Onecut3

PNG image of the network

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Top targets:


Showing 1 to 20 of 173 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_49636847 4.705 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr2_-_148046896 2.840 ENSMUST00000172928.1
ENSMUST00000047315.3
 Foxa2

forkhead box A2

chr6_-_23248264 1.888 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_+_43384332 1.842 ENSMUST00000136360.1
 Rusc2
RUN and SH3 domain containing 2
chr16_-_23890805 1.688 ENSMUST00000004480.3
 Sst
somatostatin
chr10_+_69533761 1.361 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr12_+_109545390 1.332 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr19_+_55742242 1.252 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr3_+_102010138 1.151 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr6_+_5390387 1.143 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr1_-_144177259 1.141 ENSMUST00000111941.1
ENSMUST00000052375.1
 Rgs13

regulator of G-protein signaling 13

chr19_+_55742056 1.124 ENSMUST00000111659.2
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr12_+_109544498 1.119 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr19_+_55741884 1.079 ENSMUST00000111658.3
ENSMUST00000111654.1
 Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chr11_+_78499087 1.073 ENSMUST00000017488.4
 Vtn
vitronectin
chr10_+_69533803 1.068 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
 Ank3


ankyrin 3, epithelial


chr12_+_88083697 1.067 ENSMUST00000177720.1
 Gm16368
predicted pseudogene 16368
chr9_+_55326913 0.873 ENSMUST00000085754.3
ENSMUST00000034862.4
 AI118078

expressed sequence AI118078

chr7_-_142661858 0.869 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr4_+_43383449 0.793 ENSMUST00000135216.1
ENSMUST00000152322.1
 Rusc2

RUN and SH3 domain containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.3 3.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 3.5 GO:0048625 myoblast fate commitment(GO:0048625)
0.9 2.8 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.1 2.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 1.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 1.2 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 1.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 1.1 GO:0097421 liver regeneration(GO:0097421)
0.0 1.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 0.9 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.6 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.6 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.2 0.5 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.1 0.5 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0 0.5 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.4 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.0 0.4 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.4 3.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 1.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 1.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 1.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.5 GO:0031941 filamentous actin(GO:0031941)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.1 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 3.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.6 GO:0005179 hormone activity(GO:0005179)
0.0 2.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.6 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.1 0.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.4 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.4 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.1 0.3 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924)
0.1 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)