Motif ID: Otx1

Z-value: 0.386


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.471.5e-02Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_98566762 1.700 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr10_+_3973086 1.406 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr9_+_108479849 1.288 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr3_+_54481429 0.980 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr9_+_68653761 0.876 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chr14_-_87141114 0.836 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr17_+_35861318 0.829 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chrX_-_48513518 0.785 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr5_-_37336870 0.712 ENSMUST00000031005.4
 Evc
Ellis van Creveld gene syndrome
chr5_-_37336837 0.681 ENSMUST00000114148.1
 Evc
Ellis van Creveld gene syndrome
chr4_+_58943575 0.675 ENSMUST00000107554.1
 Zkscan16
zinc finger with KRAB and SCAN domains 16
chr14_-_87141206 0.640 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr1_+_131910458 0.591 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr8_-_47675556 0.575 ENSMUST00000125536.1
 Ing2
inhibitor of growth family, member 2
chr2_-_144011202 0.527 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr7_-_38271310 0.484 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr12_-_46818749 0.484 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chr11_+_115564434 0.465 ENSMUST00000021085.4
 Nup85
nucleoporin 85
chr1_+_187215501 0.454 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
 Gpatch2



G patch domain containing 2



chr17_+_35861343 0.454 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr1_+_187215737 0.414 ENSMUST00000160471.1
 Gpatch2
G patch domain containing 2
chr2_-_60963192 0.380 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr16_-_59632520 0.356 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chr14_-_122913751 0.351 ENSMUST00000160401.1
 Ggact
gamma-glutamylamine cyclotransferase
chr10_-_93889758 0.326 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
 Metap2



methionine aminopeptidase 2



chr6_-_136828186 0.320 ENSMUST00000116514.1
 Wbp11
WW domain binding protein 11
chr11_-_116694802 0.311 ENSMUST00000079545.5
 St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr7_-_79848191 0.301 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr17_+_8165501 0.287 ENSMUST00000097419.3
ENSMUST00000024636.8
 Fgfr1op

Fgfr1 oncogene partner

chr7_-_100662315 0.276 ENSMUST00000151123.1
ENSMUST00000107047.2
 Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr2_-_11603192 0.275 ENSMUST00000040314.5
 Rbm17
RNA binding motif protein 17
chr10_-_7473361 0.266 ENSMUST00000169796.2
ENSMUST00000177585.1
 Ulbp1

UL16 binding protein 1

chr11_+_78346666 0.252 ENSMUST00000100755.3
 Unc119
unc-119 homolog (C. elegans)
chr5_+_15516489 0.252 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr10_+_127642975 0.250 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr13_+_90089705 0.247 ENSMUST00000012566.8
 Tmem167
transmembrane protein 167
chr4_-_123750236 0.239 ENSMUST00000102636.3
 Akirin1
akirin 1
chr6_-_148831395 0.232 ENSMUST00000145960.1
 Ipo8
importin 8
chr2_+_28468056 0.231 ENSMUST00000038600.3
 Mrps2
mitochondrial ribosomal protein S2
chr1_-_165708088 0.225 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr13_+_21180179 0.218 ENSMUST00000021761.5
 Trim27
tripartite motif-containing 27
chr7_-_100662414 0.218 ENSMUST00000079176.6
 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chrX_-_95956890 0.212 ENSMUST00000079987.6
ENSMUST00000113864.2
 Las1l

LAS1-like (S. cerevisiae)

chr19_-_7039987 0.211 ENSMUST00000025918.7
 Stip1
stress-induced phosphoprotein 1
chr4_-_41517326 0.210 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr10_+_29313164 0.208 ENSMUST00000160399.1
 Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr11_-_116274102 0.190 ENSMUST00000106425.3
 Srp68
signal recognition particle 68
chr3_-_146682410 0.189 ENSMUST00000124931.1
ENSMUST00000147113.1
 Samd13

sterile alpha motif domain containing 13

chr18_+_23954668 0.188 ENSMUST00000060762.4
 Zfp397
zinc finger protein 397
chr2_-_156180135 0.183 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr11_-_116274197 0.182 ENSMUST00000021133.9
 Srp68
signal recognition particle 68
chr4_-_126201117 0.181 ENSMUST00000136157.1
 Thrap3
thyroid hormone receptor associated protein 3
chr9_-_109082372 0.176 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr19_+_5689131 0.166 ENSMUST00000004156.8
 Map3k11
mitogen-activated protein kinase kinase kinase 11
chr19_-_6057736 0.163 ENSMUST00000007482.6
 Mrpl49
mitochondrial ribosomal protein L49
chr4_-_132422484 0.162 ENSMUST00000102568.3
 Phactr4
phosphatase and actin regulator 4
chr11_+_100545607 0.159 ENSMUST00000092684.5
ENSMUST00000006976.7
 Ttc25

tetratricopeptide repeat domain 25

chr7_-_4063195 0.157 ENSMUST00000068865.5
ENSMUST00000086400.6
 Lair1

leukocyte-associated Ig-like receptor 1

chr13_+_93771656 0.149 ENSMUST00000091403.4
 Arsb
arylsulfatase B
chr5_-_5749317 0.147 ENSMUST00000015796.2
 Steap1
six transmembrane epithelial antigen of the prostate 1
chr16_-_63864114 0.145 ENSMUST00000064405.6
 Epha3
Eph receptor A3
chr3_+_66985647 0.133 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chrX_+_37126777 0.126 ENSMUST00000016553.4
 Nkap
NFKB activating protein
chr9_-_66975387 0.116 ENSMUST00000034929.6
 Lactb
lactamase, beta
chr15_-_79285502 0.114 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr13_+_41016250 0.113 ENSMUST00000021790.5
 Tmem14c
transmembrane protein 14C
chr12_-_27160311 0.111 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr10_+_61648552 0.106 ENSMUST00000020286.6
 Ppa1
pyrophosphatase (inorganic) 1
chr2_+_177897096 0.102 ENSMUST00000108935.1
 Gm14327
predicted gene 14327
chr19_+_5024006 0.101 ENSMUST00000025826.5
 Slc29a2
solute carrier family 29 (nucleoside transporters), member 2
chr16_-_46010212 0.100 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr2_+_129800451 0.094 ENSMUST00000165413.2
ENSMUST00000166282.2
 Stk35

serine/threonine kinase 35

chr3_-_105960099 0.089 ENSMUST00000118209.1
 Atp5f1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
chr13_-_23368969 0.087 ENSMUST00000152557.1
 Zfp322a
zinc finger protein 322A
chr4_-_42661893 0.087 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr1_+_118321834 0.085 ENSMUST00000027626.6
ENSMUST00000112688.3
 Mki67ip

Mki67 (FHA domain) interacting nucleolar phosphoprotein

chr2_-_151980135 0.081 ENSMUST00000062047.5
 Fam110a
family with sequence similarity 110, member A
chr17_-_50094277 0.081 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr12_-_3426700 0.080 ENSMUST00000180149.1
 1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr1_+_133131143 0.074 ENSMUST00000052529.3
 Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr11_+_3963970 0.073 ENSMUST00000020705.4
ENSMUST00000109985.1
 Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr3_+_66985947 0.068 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr15_-_74734313 0.062 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr12_-_98259416 0.058 ENSMUST00000021390.7
 Galc
galactosylceramidase
chr13_-_60897439 0.055 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr2_+_178023284 0.054 ENSMUST00000108925.3
ENSMUST00000108926.2
 Etohi1

ethanol induced 1

chrM_+_11734 0.052 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr1_-_118311132 0.050 ENSMUST00000027623.7
 Tsn
translin
chr2_-_26933781 0.048 ENSMUST00000154651.1
ENSMUST00000015011.3
 Surf4

surfeit gene 4

chr16_+_91647859 0.045 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
 Son



Son DNA binding protein



chr13_-_60936550 0.042 ENSMUST00000021880.9
 Ctla2a
cytotoxic T lymphocyte-associated protein 2 alpha
chr2_+_175275125 0.034 ENSMUST00000109051.1
 Gm14440
predicted gene 14440
chr7_-_118129567 0.030 ENSMUST00000032888.7
 Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr10_+_80054029 0.023 ENSMUST00000097227.3
 Gpx4
glutathione peroxidase 4
chr8_+_46151749 0.018 ENSMUST00000154040.1
 4933411K20Rik
RIKEN cDNA 4933411K20 gene
chr18_+_86711520 0.014 ENSMUST00000122464.1
 Cbln2
cerebellin 2 precursor protein
chr13_+_104178797 0.014 ENSMUST00000022225.5
ENSMUST00000069187.5
 Trim23

tripartite motif-containing 23

chr8_-_46151705 0.013 ENSMUST00000041582.8
 Snx25
sorting nexin 25

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.3 1.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 0.2 GO:0002295 T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373)
0.1 0.9 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 0.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.3 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.8 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.1 0.2 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 0.3 GO:0097503 sialylation(GO:0097503)
0.1 0.4 GO:0046909 intermembrane transport(GO:0046909)
0.1 1.4 GO:0003416 endochondral bone growth(GO:0003416)
0.1 0.3 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.1 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0 0.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.0 0.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.6 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.3 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.4 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.5 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.5 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.3 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.1 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.7 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0043256 laminin complex(GO:0043256)
0.2 0.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.3 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 1.4 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.3 0.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 0.9 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.5 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.4 GO:0005047 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.2 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.2 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.3 GO:0008932 lytic endotransglycosylase activity(GO:0008932)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)