Motif ID: Otx1

Z-value: 0.386


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.471.5e-02Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 98 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_98566762 1.700 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr10_+_3973086 1.406 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr9_+_108479849 1.288 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr3_+_54481429 0.980 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr9_+_68653761 0.876 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chr14_-_87141114 0.836 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr17_+_35861318 0.829 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chrX_-_48513518 0.785 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr5_-_37336870 0.712 ENSMUST00000031005.4
 Evc
Ellis van Creveld gene syndrome
chr5_-_37336837 0.681 ENSMUST00000114148.1
 Evc
Ellis van Creveld gene syndrome
chr4_+_58943575 0.675 ENSMUST00000107554.1
 Zkscan16
zinc finger with KRAB and SCAN domains 16
chr14_-_87141206 0.640 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr1_+_131910458 0.591 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr8_-_47675556 0.575 ENSMUST00000125536.1
 Ing2
inhibitor of growth family, member 2
chr2_-_144011202 0.527 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr7_-_38271310 0.484 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr12_-_46818749 0.484 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chr11_+_115564434 0.465 ENSMUST00000021085.4
 Nup85
nucleoporin 85
chr1_+_187215501 0.454 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
 Gpatch2



G patch domain containing 2



chr17_+_35861343 0.454 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 1.4 GO:0003416 endochondral bone growth(GO:0003416)
0.3 1.3 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 0.9 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.8 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.0 0.7 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 0.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.6 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 0.5 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.5 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 0.4 GO:0046909 intermembrane transport(GO:0046909)
0.0 0.4 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.3 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.3 GO:0097503 sialylation(GO:0097503)
0.1 0.3 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.3 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0036064 ciliary basal body(GO:0036064)
0.2 1.3 GO:0043256 laminin complex(GO:0043256)
0.1 1.3 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 0.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.2 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.4 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.2 0.9 GO:0008142 oxysterol binding(GO:0008142)
0.3 0.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 0.5 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.4 GO:0005047 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.3 GO:0008932 lytic endotransglycosylase activity(GO:0008932)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.2 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.2 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)