Motif ID: Pax4

Z-value: 0.431


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_32696005 1.654 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
Ets1


E26 avian leukemia oncogene 1, 5' domain


chrX_+_9199865 1.373 ENSMUST00000069763.2
Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr8_-_84773381 1.294 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr8_-_70700070 1.163 ENSMUST00000116172.1
Gm11175
predicted gene 11175
chr12_-_90738438 1.137 ENSMUST00000082432.3
Dio2
deiodinase, iodothyronine, type II
chr15_-_79164477 0.863 ENSMUST00000040019.4
Sox10
SRY-box containing gene 10
chr4_-_88033328 0.827 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr9_-_58159201 0.800 ENSMUST00000041477.7
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr13_-_101768154 0.720 ENSMUST00000055518.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr2_-_168741898 0.692 ENSMUST00000109176.1
ENSMUST00000178504.1
Atp9a

ATPase, class II, type 9A

chr13_+_23738804 0.640 ENSMUST00000040914.1
Hist1h1c
histone cluster 1, H1c
chr2_+_158667119 0.606 ENSMUST00000045503.4
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr7_+_24862193 0.586 ENSMUST00000052897.4
ENSMUST00000170837.2
Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr2_+_73271925 0.583 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr5_-_103100054 0.576 ENSMUST00000112848.1
Mapk10
mitogen-activated protein kinase 10
chr2_+_158666690 0.574 ENSMUST00000103116.3
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr2_-_168741752 0.568 ENSMUST00000029060.4
Atp9a
ATPase, class II, type 9A
chr11_+_62574523 0.556 ENSMUST00000018651.7
Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr15_+_99006056 0.532 ENSMUST00000079818.3
Gm8973
predicted gene 8973
chr13_+_109632760 0.521 ENSMUST00000135275.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr15_-_88978958 0.495 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr10_-_95673451 0.495 ENSMUST00000099328.1
Anapc15-ps
anaphase prompoting complex C subunit 15, pseudogene
chr4_+_136357423 0.487 ENSMUST00000182167.1
Gm17388
predicted gene, 17388
chrX_+_142227923 0.484 ENSMUST00000042329.5
Nxt2
nuclear transport factor 2-like export factor 2
chrX_+_142228177 0.428 ENSMUST00000112914.1
Nxt2
nuclear transport factor 2-like export factor 2
chrX_-_8206475 0.408 ENSMUST00000089403.3
ENSMUST00000077595.5
ENSMUST00000089402.3
ENSMUST00000082320.5
Porcn



porcupine homolog (Drosophila)



chr9_-_101198999 0.372 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr9_-_103222063 0.350 ENSMUST00000170904.1
Trf
transferrin
chr12_+_71048338 0.334 ENSMUST00000135709.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr11_+_78499087 0.328 ENSMUST00000017488.4
Vtn
vitronectin
chr10_+_107271827 0.325 ENSMUST00000020057.8
ENSMUST00000105280.3
Lin7a

lin-7 homolog A (C. elegans)

chr7_+_7171330 0.295 ENSMUST00000051435.7
Zfp418
zinc finger protein 418
chr4_+_136284708 0.294 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr14_-_12823031 0.274 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
Cadps



Ca2+-dependent secretion activator



chrX_-_73097017 0.269 ENSMUST00000114524.2
ENSMUST00000074619.5
Xlr3a

X-linked lymphocyte-regulated 3A

chr16_-_36666067 0.259 ENSMUST00000089620.4
Cd86
CD86 antigen
chr9_+_58488568 0.240 ENSMUST00000085658.4
6030419C18Rik
RIKEN cDNA 6030419C18 gene
chr18_+_53862087 0.221 ENSMUST00000069597.6
Csnk1g3
casein kinase 1, gamma 3
chr5_-_121502980 0.219 ENSMUST00000079368.3
Adam1b
a disintegrin and metallopeptidase domain 1b
chr10_+_90071095 0.214 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_-_45366714 0.214 ENSMUST00000107779.1
Ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr5_-_116591811 0.209 ENSMUST00000076124.5
Srrm4
serine/arginine repetitive matrix 4
chr2_-_33086366 0.205 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr10_-_64090241 0.197 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr6_+_47877204 0.196 ENSMUST00000061890.7
Zfp282
zinc finger protein 282
chr4_+_136284658 0.187 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr10_+_119992916 0.176 ENSMUST00000105261.2
Grip1
glutamate receptor interacting protein 1
chr10_-_67548944 0.169 ENSMUST00000075686.4
Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr15_+_78597047 0.166 ENSMUST00000043069.5
Cyth4
cytohesin 4
chr8_-_22476809 0.152 ENSMUST00000163774.1
ENSMUST00000033935.8
Smim19

small integral membrane protein 19

chr10_-_64090265 0.152 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_+_20057802 0.144 ENSMUST00000002502.5
Hltf
helicase-like transcription factor
chr2_-_131328982 0.141 ENSMUST00000110194.1
Rnf24
ring finger protein 24
chr19_-_32712287 0.124 ENSMUST00000070210.4
Atad1
ATPase family, AAA domain containing 1
chr13_-_23430826 0.110 ENSMUST00000153753.1
ENSMUST00000141543.1
C230035I16Rik

RIKEN cDNA C230035I16 gene

chr6_+_136518820 0.107 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr4_+_147132038 0.092 ENSMUST00000084149.3
Gm13139
predicted gene 13139
chr12_+_33314277 0.089 ENSMUST00000133549.1
Atxn7l1
ataxin 7-like 1
chr10_-_62792243 0.087 ENSMUST00000020268.5
Ccar1
cell division cycle and apoptosis regulator 1
chr15_+_80977765 0.076 ENSMUST00000139517.1
ENSMUST00000042506.8
ENSMUST00000137255.1
Sgsm3


small G protein signaling modulator 3


chr4_+_146610961 0.034 ENSMUST00000130825.1
Gm13248
predicted gene 13248
chr5_+_124552845 0.029 ENSMUST00000071057.7
Ddx55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr10_+_127421124 0.028 ENSMUST00000170336.1
R3hdm2
R3H domain containing 2
chr16_+_15637844 0.028 ENSMUST00000023352.8
Prkdc
protein kinase, DNA activated, catalytic polypeptide
chrX_-_9662950 0.024 ENSMUST00000033519.2
Dynlt3
dynein light chain Tctex-type 3
chr1_-_88008520 0.020 ENSMUST00000040783.4
Usp40
ubiquitin specific peptidase 40
chr5_+_66676098 0.019 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr2_+_22895583 0.015 ENSMUST00000152170.1
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr17_+_35059035 0.012 ENSMUST00000007255.6
ENSMUST00000174493.1
Ddah2

dimethylarginine dimethylaminohydrolase 2

chrX_+_73192222 0.010 ENSMUST00000101486.4
Xlr3b
X-linked lymphocyte-regulated 3B
chr9_+_36832684 0.000 ENSMUST00000034630.8
Fez1
fasciculation and elongation protein zeta 1 (zygin I)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.3 1.2 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.2 1.1 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.1 0.4 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.5 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 0.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 1.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.8 GO:0007379 segment specification(GO:0007379)
0.1 0.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.9 GO:0048484 enteric nervous system development(GO:0048484)
0.1 0.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.3 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.5 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.3 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.0 0.3 GO:0097421 liver regeneration(GO:0097421)
0.0 1.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.3 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.6 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.0 0.3 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.6 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.9 GO:0055037 recycling endosome(GO:0055037)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.2 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.5 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)