Motif ID: Pax6

Z-value: 0.732


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105682463_105682547-0.783.0e-06Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_103422010 4.484 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr13_-_110280103 2.819 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr2_-_162661075 2.207 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr19_-_57118981 2.011 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr1_-_38836090 1.614 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr19_-_57118897 1.561 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr6_-_60829826 1.491 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr3_-_89245159 1.470 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr6_-_118780324 1.442 ENSMUST00000112793.3
ENSMUST00000075591.6
ENSMUST00000078320.7
ENSMUST00000112790.2
 Cacna1c



calcium channel, voltage-dependent, L type, alpha 1C subunit



chr5_+_90903864 1.343 ENSMUST00000075433.6
 Cxcl2
chemokine (C-X-C motif) ligand 2
chr5_+_112255813 1.256 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
 Crybb1


crystallin, beta B1


chr3_-_89245005 1.226 ENSMUST00000107464.1
 Trim46
tripartite motif-containing 46
chr17_+_43568096 1.224 ENSMUST00000167214.1
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr4_+_85205417 1.183 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr18_+_37447641 1.095 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr5_-_18360384 1.086 ENSMUST00000074694.5
 Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr17_+_43016536 1.078 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr3_+_65109343 1.075 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr18_-_34373313 1.026 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chr5_+_149265035 0.978 ENSMUST00000130144.1
ENSMUST00000071130.3
 Alox5ap

arachidonate 5-lipoxygenase activating protein

chr13_+_64432479 0.975 ENSMUST00000021939.6
 Cdk20
cyclin-dependent kinase 20
chr15_-_101850778 0.849 ENSMUST00000023790.3
 Krt1
keratin 1
chr6_-_122856151 0.810 ENSMUST00000042081.8
 C3ar1
complement component 3a receptor 1
chr6_+_123229843 0.697 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
 Clec4n


C-type lectin domain family 4, member n


chr17_-_33718591 0.682 ENSMUST00000174040.1
ENSMUST00000173015.1
ENSMUST00000066121.6
ENSMUST00000172767.1
ENSMUST00000173329.1
 March2




membrane-associated ring finger (C3HC4) 2




chr5_-_142906702 0.674 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
 Actb


actin, beta


chr10_+_80356459 0.666 ENSMUST00000039836.8
ENSMUST00000105351.1
 Plk5

polo-like kinase 5

chr15_+_6299781 0.659 ENSMUST00000078019.6
 Dab2
disabled 2, mitogen-responsive phosphoprotein
chr15_+_6299797 0.609 ENSMUST00000159046.1
ENSMUST00000161040.1
 Dab2

disabled 2, mitogen-responsive phosphoprotein

chr7_+_5051515 0.596 ENSMUST00000069324.5
 Zfp580
zinc finger protein 580
chr7_-_12775658 0.522 ENSMUST00000046245.5
 Zscan18
zinc finger and SCAN domain containing 18
chr12_+_112976471 0.512 ENSMUST00000165079.1
ENSMUST00000002880.6
 Btbd6

BTB (POZ) domain containing 6

chr11_+_67966442 0.467 ENSMUST00000021286.4
ENSMUST00000108675.1
 Stx8

syntaxin 8

chr6_-_124741374 0.460 ENSMUST00000004389.5
 Grcc10
gene rich cluster, C10 gene
chr6_-_88045190 0.420 ENSMUST00000113596.1
ENSMUST00000113600.3
 Rab7

RAB7, member RAS oncogene family

chr11_-_6200411 0.398 ENSMUST00000066496.3
 Nudcd3
NudC domain containing 3
chr14_+_34170640 0.387 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr17_-_57059795 0.356 ENSMUST00000040280.7
 Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr8_-_57962564 0.346 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr15_+_103272893 0.334 ENSMUST00000100162.3
 Copz1
coatomer protein complex, subunit zeta 1
chr13_-_113618549 0.317 ENSMUST00000109241.3
 Snx18
sorting nexin 18
chr16_+_4968936 0.289 ENSMUST00000090457.5
 4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr9_+_50775347 0.283 ENSMUST00000159576.1
 Alg9
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
chr16_-_22857514 0.280 ENSMUST00000004576.6
 Tbccd1
TBCC domain containing 1
chrX_+_73214333 0.279 ENSMUST00000156188.1
ENSMUST00000069077.3
ENSMUST00000069103.4
ENSMUST00000114506.1
ENSMUST00000081827.3
 Xlr4b




X-linked lymphocyte-regulated 4B




chr17_+_34604262 0.252 ENSMUST00000174041.1
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr9_+_15239045 0.240 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr15_-_35938009 0.209 ENSMUST00000156915.1
 Cox6c
cytochrome c oxidase subunit VIc
chr7_-_86775860 0.202 ENSMUST00000001824.5
 Folh1
folate hydrolase 1
chr4_-_3835595 0.193 ENSMUST00000138502.1
 Rps20
ribosomal protein S20
chrX_+_23693043 0.179 ENSMUST00000035766.6
ENSMUST00000101670.2
 Wdr44

WD repeat domain 44

chr19_+_34290653 0.179 ENSMUST00000025691.5
ENSMUST00000112472.2
 Fas

Fas (TNF receptor superfamily member 6)

chr11_-_67965631 0.177 ENSMUST00000021287.5
ENSMUST00000126766.1
 Wdr16

WD repeat domain 16

chr4_+_155491353 0.172 ENSMUST00000165335.1
ENSMUST00000105616.3
ENSMUST00000030940.7
 Gnb1


guanine nucleotide binding protein (G protein), beta 1


chr2_+_163602294 0.166 ENSMUST00000171696.1
ENSMUST00000109408.3
 Ttpal

tocopherol (alpha) transfer protein-like

chr13_-_53377355 0.145 ENSMUST00000021920.6
 Sptlc1
serine palmitoyltransferase, long chain base subunit 1
chr6_-_113377376 0.142 ENSMUST00000043333.2
 Tada3
transcriptional adaptor 3
chr15_+_84669565 0.134 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr11_+_78328415 0.126 ENSMUST00000048073.8
 Pigs
phosphatidylinositol glycan anchor biosynthesis, class S
chr10_-_127189981 0.122 ENSMUST00000019611.7
 Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr7_-_86775808 0.114 ENSMUST00000107271.3
 Folh1
folate hydrolase 1
chr6_-_145048809 0.110 ENSMUST00000032402.5
 Bcat1
branched chain aminotransferase 1, cytosolic
chr15_-_35938186 0.100 ENSMUST00000014457.8
 Cox6c
cytochrome c oxidase subunit VIc
chr5_-_74677792 0.078 ENSMUST00000117525.1
ENSMUST00000153543.1
ENSMUST00000039744.6
ENSMUST00000113531.2
ENSMUST00000121690.1
 Lnx1




ligand of numb-protein X 1




chr8_-_72475212 0.078 ENSMUST00000079510.4
 Cherp
calcium homeostasis endoplasmic reticulum protein
chr19_+_6400611 0.069 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr7_-_80901220 0.069 ENSMUST00000146402.1
ENSMUST00000026816.8
 Wdr73

WD repeat domain 73

chr1_-_180813591 0.058 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
 H3f3a


H3 histone, family 3A


chr16_+_20498817 0.053 ENSMUST00000003320.6
 Eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
chr1_+_43092588 0.042 ENSMUST00000039080.3
 8430432A02Rik
RIKEN cDNA 8430432A02 gene
chr1_-_195131536 0.031 ENSMUST00000075451.6
 Cr1l
complement component (3b/4b) receptor 1-like
chr8_+_31150307 0.031 ENSMUST00000098842.2
 Tti2
TELO2 interacting protein 2
chr7_+_12897800 0.025 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
 Zscan22



zinc finger and SCAN domain containing 22



chr2_+_105904629 0.018 ENSMUST00000037499.5
 Immp1l
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr7_+_141228766 0.014 ENSMUST00000106027.2
 Phrf1
PHD and ring finger domains 1
chr6_+_48395586 0.005 ENSMUST00000114571.1
ENSMUST00000114572.3
ENSMUST00000031815.5
 Krba1


KRAB-A domain containing 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 0.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.4 1.5 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
0.4 1.4 GO:0098912 smooth muscle contraction involved in micturition(GO:0060083) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.4 1.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.3 1.0 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.3 1.3 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.2 1.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.1 0.6 GO:0061724 lipophagy(GO:0061724)
0.1 0.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.4 GO:0097274 urea homeostasis(GO:0097274)
0.1 1.1 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 0.7 GO:0002347 response to tumor cell(GO:0002347)
0.1 1.3 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 1.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.1 0.7 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.3 GO:0036089 cleavage furrow formation(GO:0036089)
0.0 0.7 GO:0050832 defense response to fungus(GO:0050832)
0.0 3.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.2 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.2 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.2 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 0.6 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 2.8 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.1 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 1.3 GO:0007601 visual perception(GO:0007601)
0.0 0.5 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.3 GO:0006760 folic acid-containing compound metabolic process(GO:0006760)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 1.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 1.1 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 0.7 GO:0070688 MLL5-L complex(GO:0070688)
0.1 0.8 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 3.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.5 GO:0031902 late endosome membrane(GO:0031902)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0050544 arachidonic acid binding(GO:0050544)
0.3 1.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 0.8 GO:0004942 anaphylatoxin receptor activity(GO:0004942)
0.2 2.2 GO:0051393 alpha-catenin binding(GO:0045294) alpha-actinin binding(GO:0051393) delta-catenin binding(GO:0070097)
0.2 1.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.1 2.8 GO:0031489 myosin V binding(GO:0031489)
0.1 1.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.7 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.1 GO:0070402 NADPH binding(GO:0070402)
0.1 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 1.0 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758)
0.0 1.0 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.3 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)