Motif ID: Pax6

Z-value: 0.732


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105682463_105682547-0.783.0e-06Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Showing 1 to 20 of 76 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 4.484 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr13_-_110280103 2.819 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr2_-_162661075 2.207 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr19_-_57118981 2.011 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr1_-_38836090 1.614 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr19_-_57118897 1.561 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr6_-_60829826 1.491 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr3_-_89245159 1.470 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr6_-_118780324 1.442 ENSMUST00000112793.3
ENSMUST00000075591.6
ENSMUST00000078320.7
ENSMUST00000112790.2
 Cacna1c



calcium channel, voltage-dependent, L type, alpha 1C subunit



chr5_+_90903864 1.343 ENSMUST00000075433.6
 Cxcl2
chemokine (C-X-C motif) ligand 2
chr5_+_112255813 1.256 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
 Crybb1


crystallin, beta B1


chr3_-_89245005 1.226 ENSMUST00000107464.1
 Trim46
tripartite motif-containing 46
chr17_+_43568096 1.224 ENSMUST00000167214.1
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr4_+_85205417 1.183 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr18_+_37447641 1.095 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr5_-_18360384 1.086 ENSMUST00000074694.5
 Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr17_+_43016536 1.078 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr3_+_65109343 1.075 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr18_-_34373313 1.026 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chr5_+_149265035 0.978 ENSMUST00000130144.1
ENSMUST00000071130.3
 Alox5ap

arachidonate 5-lipoxygenase activating protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 3.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.8 GO:0019882 antigen processing and presentation(GO:0019882)
0.4 1.5 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
0.4 1.4 GO:0098912 smooth muscle contraction involved in micturition(GO:0060083) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.3 1.3 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 1.3 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 1.3 GO:0007601 visual perception(GO:0007601)
0.2 1.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 1.2 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.4 1.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.1 1.1 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 1.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.3 1.0 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.4 0.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.7 GO:0002347 response to tumor cell(GO:0002347)
0.1 0.7 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.7 GO:0050832 defense response to fungus(GO:0050832)
0.1 0.6 GO:0061724 lipophagy(GO:0061724)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.5 GO:0008021 synaptic vesicle(GO:0008021)
0.4 1.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 1.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.2 1.1 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.8 GO:0045095 keratin filament(GO:0045095)
0.1 0.7 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.5 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.4 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0031489 myosin V binding(GO:0031489)
0.4 2.5 GO:0050544 arachidonic acid binding(GO:0050544)
0.2 2.2 GO:0051393 alpha-catenin binding(GO:0045294) alpha-actinin binding(GO:0051393) delta-catenin binding(GO:0070097)
0.3 1.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.2 1.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.1 GO:0070402 NADPH binding(GO:0070402)
0.1 1.0 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.0 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.3 0.8 GO:0004942 anaphylatoxin receptor activity(GO:0004942)
0.1 0.7 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.3 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758)